Co-existence of gastric adenocarcinoma and neuroendocrine carcinoma: a rare entity

A mixed adenoneuroendocrine carcinoma is a tumor composed of both adenocarcinoma and neuroendocrine carcinoma components, with each comprising  at least one-third of the lesion, as defined by the World Health Organization classification of neuroendocrine neoplasms in 2010.. A 67-years-old male was admitted to the hospital with symptoms suggesting gastric cancer. Histopathology examination from endoscopic biopsy revealed adenocarcinoma. Later partial gastrectomy specimen examination the lesion show presence of well differentiated adenocarcinoma along with neuro endocrine carcinoma.</p

Correlation of Serum Immunoglobulin A and Immunoglobulin A / Complement 3 Ratio with IgA Nephropathy: One Year Prospective Study

Background: IgA nephropathy is the most prevalent primary glomerulonephritis worldwide, characterized by the mesangial deposition of IgA immune complexes.Its clinical course is highly variable, ranging from indolent to rapidly progressive forms, and it represents a significant challenge in nephrology. The diagnostic potential of the IgA/C3 ratio, can provide valuable insights into the underlying immunological processes. Materials and Methods: This is a one year prospective study done in the department of renal pathology at Pratham pathology private limited during the period of 1st November 2021-30th October 2022. Data of all patients were evaluated for the histopathological diagnosis. Report of all cases were reviewed for prebiopsy report of serum IgA and C3 level. All cases of which serum IgA and C3 done were included for the study. Those cases, which didn’t perform serum IgA and C3, were excluded from the study. Results: A total of 182 cases of kidney biopsies were received for evaluation during this period. Out of it 22 cases (12.08 %) were those of IgA Nephropathy.  Of which, 13 patients had done a blood level of IgA and C3. There was no statistical difference between serum C3 level, IgA and/or IgA/C3 between IgA nephropathy and non IgA nephropathy. Conclusion: There is no significance variation between serum IgA, C3 and /or IgA/C3 level between IGA nephropathy and other glomerular diseases

Aspiration and non-aspiration technique in the study of thyroid gland lesion cytology

Background: Fine needle aspiration cytology is used as a primary diagnostic tool in thyroid lesions. But the bloody smears caused by negative pressure during aspiration compromise cellular concentration and cell morphology which may lead to its improper interpretation. FNNAC avoids active aspiration and depends on capillary tension to collect tissue sample in the needle bore, thus reducing bleeding and tissue trauma to the highly vascular thyroid. Material and Methods: This is a one year prospective study where FNNAC and FNAC were done on 87 patients. Cytopathologist was blind folded regarding the technique used and was asked to score the quality of slide base of Mair scoring system.Results: FNAC yielded significantly better material on the basis of hemorrhage and cellularity. Fifty six (64.37%) cases showed adequate diagnostic material in FNNAC technique while 54/87 (62.05%) cases showed adequate diagnostic material in FNAC technique. Twelve (13.79%) cases showed unsuitable diagnostic material in FNNAC technique and 26/ 87 (29.89%) cases unsuitable diagnostic material in FNAC technique. Among the individual criteria used in Mair scoring system, background clot/ blood was significantly low in FNNAC than FNAC with the p value less than 0.001. Amount of cellular material was significantly more in FNNAC with p value less than 0.001.Conclusion: FNNAC yielded more cellular and less hemorrhagic material and more diagnostic superior material than FNAC. Since thyroid is a highly vascular gland, FNNAC should be used instead of FNAC for less hemorrhagic and more cellular material.</p