Development and evaluation of Zotepine loaded mucoadhesive microemulsion for intranasal delivery

Mania and bipolar illness are the major problems in the schizophrenia treatment, zotepine, atypical antipsychotic drug used for this condition. The aim of present investigation was to develop mucoadhesive microemulsion of zotepine for intranasal delivery by phase titration method. The developed formulations were evaluated for its size, zeta, PDI and invitro release studied. The optimized formulation, containing 5% Oleic acid, 40% Tween 80: PEG400 (3:1) and 55% water. The globule size (53.1±0.31), zeta potential (-32.1±0.2),PDI (0.13±0.23).0.5% chitosan was added to the optimized formulation to prepare mucoadhesive formulation. Keywords: Zotepine; Microemulsion; pseudoternary phase diagram; solubility