693 research outputs found
Biologic Agents—A Panacea for Inflammatory Arthritis or Not?
Aim. To describe the retention rates for biological therapies in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) in a clinical setting. Methods. All patients managed in a dedicated biological therapy clinic in a teaching hospital in Australia were assessed for continuation on biological treatments and reasons for switching to an alternative biological agent or cessation of treatment. Results. There was a lower retention rate for RA patients on biological therapies compared to PsA and AS patients and the retention rate for RA patients was lower than that reported in RCTs. Conclusions. The retention rate on biological therapies for RA patients was lower in the clinic setting than what is reported in RCTs. The reasons for the lower retention rate in the clinical setting are discussed but no clear determinants for nonresponse to biological agents were identifiable. These agents have very limited steroid sparing effects
Large-scale mapping of the massive star-forming region RCW38 in the [CII] and PAH emission
We investigate the large-scale structure of the interstellar medium (ISM)
around the massive star cluster RCW38 in the [CII] 158 um line and polycyclic
aromatic hydrocarbon (PAH) emission. We carried out [CII] line mapping of an
area of ~30'x15' for RCW~38 by a Fabry-Perot spectrometer on a 100 cm
balloon-borne telescope with an angular resolution of ~1'.5. We compared the
[CII] intensity map with the PAH and dust emission maps obtained by the AKARI
satellite. The [CII] emission shows a highly nonuniform distribution around the
cluster, exhibiting the structure widely extended to the north and the east
from the center. The [CII] intensity rapidly drops toward the southwest
direction, where a CO cloud appears to dominate. We decompose the 3-160 um
spectral energy distributions of the surrounding ISM structure into PAH as well
as warm and cool dust components with the help of 2.5-5 um spectra. We find
that the [CII] emission spatially corresponds to the PAH emission better than
to the dust emission, confirming the relative importance of PAHs for
photo-electric heating of gas in photo-dissociation regions. A naive
interpretation based on our observational results indicates that molecular
clouds associated with RCW38 are located both on the side of and behind the
cluster.Comment: 10 pages, 7 figures, accepted for publication in A&
Overview of the spectrometer optical fiber feed for the Habitable-zone Planet Finder
The Habitable-zone Planet Finder (HPF) is a highly stabilized fiber fed
precision radial velocity (RV) spectrograph working in the Near Infrared (NIR):
810 - 1280 nm . In this paper we present an overview of the preparation of the
optical fibers for HPF. The entire fiber train from the telescope focus down to
the cryostat is detailed. We also discuss the fiber polishing, splicing and its
integration into the instrument using a fused silica puck. HPF was designed to
be able to operate in two modes, High Resolution (HR- the only mode mode
currently commissioned) and High Efficiency (HE). We discuss these fiber heads
and the procedure we adopted to attach the slit on to the HR fibers.Comment: Presented at 2018 SPIE Astronomical Telescopes + Instrumentation,
Austin, Texas, USA. 18 pages, 25 figures, and 2 table
TIRSPEC : TIFR Near Infrared Spectrometer and Imager
We describe the TIFR Near Infrared Spectrometer and Imager (TIRSPEC) designed
and built in collaboration with M/s. Mauna Kea Infrared LLC, Hawaii, USA, now
in operation on the side port of the 2-m Himalayan Chandra Telescope (HCT),
Hanle (Ladakh), India at an altitude of 4500 meters above mean sea level. The
TIRSPEC provides for various modes of operation which include photometry with
broad and narrow band filters, spectrometry in single order mode with long
slits of 300" length and different widths, with order sorter filters in the Y,
J, H and K bands and a grism as the dispersing element as well as a cross
dispersed mode to give a coverage of 1.0 to 2.5 microns at a resolving power R
of ~1200. The TIRSPEC uses a Teledyne 1024 x 1024 pixel Hawaii-1 PACE array
detector with a cutoff wavelength of 2.5 microns and on HCT, provides a field
of view of 307" x 307" with a plate scale of 0.3"/pixel. The TIRSPEC was
successfully commissioned in June 2013 and the subsequent characterization and
astronomical observations are presented here. The TIRSPEC has been made
available to the worldwide astronomical community for science observations from
May 2014.Comment: 20 pages, 21 figures, 2 tables. Accepted for publication in Journal
of Astronomical Instrumentatio
Developmental Studies on Metallised UDMH and Kerosene Gels
The influence of particulate and hydrocolloid gellants and different surfactants on gellation of metallised stable gels of unsymmetrical dimethyl hydrazine (UDMH) and kerosene containing 30 per cent 15 micron Aluminium was studied. Metallised UDMH and kerosene gels were characterised with respect to pseudoplasticity, thixotropy, consistency and yield stress using Contrave's rheometer. The effect of shear rate and temperature on the viscosity of these gels was determined. Thermal stability, hypergolicity tests and flow rate studies were also conducted. Metallised UDMH and kerosene gels are found to be stable, thixotropic and pseudoplastic and easily flowing like a liquid under shear force
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