Ideas and perspectives: Ushering the Indian Ocean into the UN Decade of Ocean Science for Sustainable Development (UNDOSSD) through marine ecosystem research and operational services – an early career's take

The Indian Ocean Rim hosts many of the world's underdeveloped and emerging economies that depend on the ocean resources for the livelihoods of the populations of millions. Operational ocean information services cater to the requirements of managers and end-users to efficiently harness those resources and to ensure safety. Fishery information is not the only operational service that will be needed to empower such communities in the coming decades. Coral bleaching alerts, SCUBA (self-contained underwater breathing apparatus)-assisting advisories, conservation or ecotourism assisting services (e.g. TurtleWatch or WhaleWatch), poaching and/or by-catch reduction support and jellyfish, micro-plastic and oil spill watching to name a few, but not an exhaustive list, of the services that are needed operationally. This paper outlines the existing tools and explores the ongoing research that has potential to convert the findings into operational services in near- to midterm.</p

Multiple Patients Behavior Detection in Real-time using mmWave Radar and Deep CNNs

To address potential gaps noted in patient monitoring in the hospital, a novel patient behavior detection system using mmWave radar and deep convolution neural network (CNN), which supports the simultaneous recognition of multiple patients' behaviors in real-time, is proposed. In this study, we use an mmWave radar to track multiple patients and detect the scattering point cloud of each one. For each patient, the Doppler pattern of the point cloud over a time period is collected as the behavior signature. A three-layer CNN model is created to classify the behavior for each patient. The tracking and point clouds detection algorithm was also implemented on an mmWave radar hardware platform with an embedded graphics processing unit (GPU) board to collect Doppler pattern and run the CNN model. A training dataset of six types of behavior were collected, over a long duration, to train the model using Adam optimizer with an objective to minimize cross-entropy loss function. Lastly, the system was tested for real-time operation and obtained a very good inference accuracy when predicting each patient's behavior in a two-patient scenario.Comment: This paper has been submitted to IEEE Radar Conference 201

Utility of Sea Surface Height anomaly (SSHa)in determination of Potential Fishing Zones

Physical processes in the oceans can be monitored by altimeters well before a radiometer can in terms of temperature or chlorophyll concentration. Herein we show the importance of Sea Surface Height anomaly (SSHa, retrieved with altimeter) in demarcating potential fishing zones. We also show how SSHa can help predict tuna movements, horizontally as well as vertically in the water column. Moreover, we prove these prediction with positively correlating SSHa to tuna hooking rates. In the end, we list out present and potential future sources from where SSHa can be retrieved in order to provide improved fishery advisories

Automated Identification of Oceanic Fronts for Operational Generation of Potential Fishing Zone (PFZ) Advisories

PFZs, are essentially the frontal structures as identified from the satellite images of Sea Surface Temperature (SST) and chlorophyll concentration. These regions are known for fish aggregation and provide cost-effectiveness in offshore fishing operations. Subjective identification of fronts may lead to human-errors, non-negotiable beyond a limit. To overcome this, we propose utilization of tools that help automated identification of the frontal structures. This approach not only removes the errors, but also helps shorten the time period of the operational process-chai

Following tagged Yellowfin tuna along the east coast of India explains its feeding behavior: a case study in the Bay of Bengal

Horizontal movement of pelagic fish predator, Yellowfin (Thunnus albacares) tuna, in the oceanic waters of Bay of Bengal has been decoded. Pop-up Satellite Archival Tags (PSATs) were attached to adult tunas to study their distribution and migration. For this, environmental satellite data were matched with the tag locations to understand and characterize habitats of this species. A sub-set of the tag data was selected corresponding to the maximum resident time of tuna indicated by a high density data points. The tagged tuna spent 60 to 70% of its time in the waters having surface temperature within 28o to 29.5oC and sea surface height anomaly within+5 to +12 cm. The tag positions were located on the satellite images; chlorophyll, sea surface temperature, zooplankton and sea surface height anomaly. The two conditions, specific range of temperature and prey abundance, were found necessary for aggregation of tuna

Single versus dual antiplatelet therapy following peripheral arterial endovascular intervention for chronic limb threatening ischaemia:retrospective cohort study

ObjectivesAntiplatelet therapy following peripheral arterial endovascular intervention lacks high quality evidence to guide practice. The aim of this study was to assess the effect of three months of dual antiplatelet therapy on amputation-free survival following peripheral arterial endovascular intervention in patients with chronic limb threatening ischemia.MethodsA retrospective review of symptomatic patients undergoing primary peripheral arterial endovascular intervention over a seven-year period was performed. The primary outcome measure was amputation-free survival. A sample size calculation based on previous cohort studies suggested that 629 limbs would be required to show a difference between single and dual therapy. Kaplan-Meier estimates and multivariate logistic regression analysis of recorded baseline characteristics was performed to determine predictors of amputation-free survival. Dual antiplatelet therapy was routinely given for 3 months.Results754 limbs were treated with primary angioplasty and/or stenting over a 7-year period, 508 of these for chronic limb threatening ischemia. There was no difference in unadjusted amputation-free survival between patients with chronic limb threatening ischaemia taking single vs. dual antiplatelet therapy (69% vs. 74% respectively Log rank Chi2 = 0.1, p = .72). After adjusting for confounders, at 1 year there was also no significant difference in amputation-free survival between patients taking single vs. dual antiplatelet therapy [OR 0.8, 95% CI 0.5-1.2, p = .3]. There was no difference in rates of major bleeding between single and dual antiplatelet therapy.ConclusionsThere was no clear evidence of reduced amputation-free survival in patients with chronic limb threatening ischemia undergoing peripheral arterial endovascular intervention being treated with dual antiplatelet therapy for 3 months. This is at odds with other retrospective case series and highlights the limitations in basing clinical practice on such data. There is a need for an adequately powered, independent randomised trial to definitively answer the question

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression

Neutrophils are a vital component of immune protection, yet in cancer they may promote tumour progression, partly by generating reactive oxygen species (ROS) that disrupts lymphocyte functions. Metabolically, neutrophils are often discounted as purely glycolytic. Here we show that immature, c-Kit+ neutrophils subsets can engage in oxidative mitochondrial metabolism. With limited glucose supply, oxidative neutrophils use mitochondrial fatty acid oxidation to support NADPH oxidase-dependent ROS production. In 4T1 tumour-bearing mice, mitochondrial fitness is enhanced in splenic neutrophils and is driven by c-Kit signalling. Concordantly, tumour-elicited oxidative neutrophils are able to maintain ROS production and T cell suppression when glucose utilisation is restricted. Consistent with these findings, peripheral blood neutrophils from patients with cancer also display increased immaturity, mitochondrial content and oxidative phosphorylation. Together, our data suggest that the glucose-restricted tumour microenvironment induces metabolically adapted, oxidative neutrophils to maintain local immune suppression

Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

The foreign body response is an immune-mediated reaction that can lead to the failure of implanted medical devices and discomfort for the recipient. There is a critical need for biomaterials that overcome this key challenge in the development of medical devices. Here we use a combinatorial approach for covalent chemical modification to generate a large library of variants of one of the most widely used hydrogel biomaterials, alginate. We evaluated the materials in vivo and identified three triazole-containing analogs that substantially reduce foreign body reactions in both rodents and, for at least 6 months, in non-human primates. The distribution of the triazole modification creates a unique hydrogel surface that inhibits recognition by macrophages and fibrous deposition. In addition to the utility of the compounds reported here, our approach may enable the discovery of other materials that mitigate the foreign body response.Leona M. and Harry B. Helmsley Charitable Trust (3-SRA-2014-285-M-R)United States. National Institutes of Health (EB000244)United States. National Institutes of Health (EB000351)United States. National Institutes of Health (DE013023)United States. National Institutes of Health (CA151884)United States. National Institutes of Health (P41EB015871-27)National Cancer Institute (U.S.) (P30-CA14051