Treatment of cutaneous leishmaniasis: cassia fistula fruit gel- intralesional glucantime Vs. placebo gel- intralesional glucantime combination

"n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Cutaneous leishmaniasis is a major health problem in Iran and especially Isfahan province is considered as an endemic area for this disease. Regarding the previous report of positive effects of Cassia fistula boiled extract in the treatment of cutaneous leishmaniasis, this study was designed to evaluate the effect of combination therapy with intralesional meglumine antimoniate and Cassia fistula fruit gel compared to placebo in this disease."n"nMethods: 140 patients with cutaneous leishmaniasis referring to Skin Disease and Leishmaniasis Research Center of Isfahan (SDLRC) were randomly allocated in two groups. One group received intralesional meglumine antimoniate injection and Cassia fistula fruit gel and the second group were treated with intralesional meglumine antimoniate and placebo gel. Improvement was defined as complete cure, partial cure and treatment failure. "n"nResults: At 12 week, 47 patients treated with intralesional meglumine antimoniate and topical Cassia fistula fruit gel achieved complete cure (67.1%) compared to 29(41.4%) patients in placebo treated group. There was significant difference in cure rate between two treatment groups of this study (p<0.001). Nine patients (19%) in each group suffered from adverse effects of the treatment such as itching and erythema. There was no significant difference in this regard between two groups (p=0.82). "n"nConclusions: The results of this study shows the efficacy of Cassia fistula fruit gel in increasing the cure rate of cutaneous leishmaniasis lesions achieved by intralesional meglumine antimoniate. Combination therapy of intralesional meglumine antimoniate and Cassia fistula fruit gel could be suggested as a choice for the treatment of acute cutaneous leishmaniasis lesions

The effectiveness of mix extracts of Thyme, Yarrow and Propolis on Cutaneous Leishmaniasis: a comparative study in animal model (Balb/c)

"nBackground: Though many therapeutic modalities have been suggested but still no definite treatment for Cutaneous Leishmaniasis is available. Many compounds including Alkaloid, Quinones, Iridoids, Terpenes, Indole analogue have been documented to have antileishmania activity invitro. On the other hand, the aforementioned compounds can be found in the herbs including Thyme, Yarrow. Propolis is a brown color substance that is collected by honey bee from plants. Regarding the lack of data about the possible efficacy of these herbs against leishmaniasis, we have decided to evaluate and compare the efficacy of herbal extract of Thyme, Yarrow, Propolis and systemic glucantime against cutaneous leishmaniasis in Balb/c, and to formulate drugs without harmful chemical material and without side effect. "nMethods: During three weeks of inoculation of parasite in base tail of mice, lesions will appear in the inoculation site. The animals divided into seven groups. We used mix alchoholic extract solution two times a day, checked lesions weekly for six week and measured size of lesion in the base of tail with kulis- vernieh. "nResults: We observed significant difference between mean of lesion diameter before and after treatment in control, Yarrow and Thyme groups (p<0.05). Paired t test showed no significant difference between mean of lesion diameter after treatment between treatment and glucantime groups (p>0.05). "nConclusion: Alchoholic extract to Thyme and Yarrow have good effect on lesions treatment, we suggest repeat of this study with Thyme and Yarrow extract in gel or cream base in first stage of lesions appearance