9 research outputs found

    Determination of Inactive Powers in a Single-Phase AC Network

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    Based on the development of the theory of reactive power and distortion power, starting with the works of Fryze and Budeanu, it has been found that the contradictions in the definition of the components of inactive powers are caused by errors in the introduced intermediate concepts and corresponding calculations when switching to nonlinear and non-sinusoidal AC circuits. The materials of the works of modern researchers and the numerical calculations carried out made it possible to trace the differences between reactive power and distortion power, to confirm the orthogonality properties of the active, reactive power, and distortion power components. The paper defines the conditions for achieving a power balance in an AC network with nonlinear loads, compiled and tested criteria leading to the absence of distortion power in a single-phase AC network. Using the time base of the projection of the generalized vectors in vector diagrams, it is shown that compliance with the criteria for the absence of distortion power does not determine the mutual similarity of the voltage curve with the current curve for a nonlinear load. It has been found that the well-known term β€œdistortion power” has an unfortunate wording, since this power, although it characterizes the interaction of harmonics of currents and voltages with different ordinal numbers, is not determined by the visual similarity or the degree of distortion of the load current waveforms relative to the supply voltage curve

    Degradation of Lithium-Ion Batteries in an Electric Transport Complex

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    The article provides an overview and comparative analysis of various types of batteries, including the most modern type-lithium-ion batteries. Currently, lithium-ion batteries (LIB) are widely used in electrical complexes and systems, including as a traction battery for electric vehicles. Increasing the service life of the storage devices used today is an important scientific and technical problem due to their rapid wear and tear and high cost. This article discusses the main approaches and methods for researching the LIB resource. First of all, a detailed analysis of the causes of degradation was carried out and the processes occurring in lithium-ion batteries during charging, discharging, resting and difficult operating conditions were established. Then, the main factors influencing the service life are determined: charging and discharging currents, self-discharge current, temperature, number of cycles, discharge depth, operating range of charge level, etc. when simulating a real motion process. The work considers the battery management systems (BMS) that take into account and compensate for the influence of the factors considered. In the conclusion, the positive and negative characteristics of the presented methods of scientific research of the residual life of LIB are given and recommendations are given for the choice of practical solutions to engineers and designers of batteries. The work also analyzed various operating cycles of electric transport, including heavy forced modes, extreme operating modes (when the amount of discharge and discharge of batteries is greater than the nominal value) and their effect on the degradation of lithium-ion batteries

    Mental hygiene of interpersonal relations of student-managers in a megapolis

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    The article presents a psychological analysis of the behavior features and interpersonal relations of students-managers in a metropolis. The relevance of the present work is determined by the fact that for young people, higher education is associated with a change in their social status when they move from direct dependence on their parents to independent actions and active life in a big city. The specifics of the urban space of a metropolis have a strong influence on their mental state and understanding of the world around them. The popularity of the manager’s profession among young people entering universities has also contributed to the relevance of the study. Young people set themselves the goal of β€œlearning to manage and lead.” The conditions of the big city impose special requirements on future managers, focusing them on the implementation of adaptive psychological functions. The manager’s ability to conform to social attitudes, to create a pleasant impression for others becomes for him a professionally important quality. As a result, students face a paradoxical situation involving a system of β€œdouble standards”. In this regard, they encounter difficulties in social adaptation and the formation of stable interpersonal relationships. To solve this problem, an empirical study was conducted, which allowed determining the values of the main strategies of interpersonal relations based on a comparative analysis of the basic ideas of first-year students. Empirical data were obtained based on the psychological method by L.N. Sobchik β€œDiagnostics of interpersonal relations” (DIR). The results obtained make it possible to carry out preventive psychohygienic activities with students to form their social adaptability and maintain mental health

    Pediatric endocrine surgery development

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    Department of pediatric surgery at the Endocrinology Research Centre has been around for nearly two years. During operation, surgical treatment has received more than 500 patients with various endocrine disorders. The article discusses modern diagnostic approaches and surgical options for diseases included in the new direction of pediatric surgery endocrine surgery in children. There are discussions about options for radical treatment of Graves disease in children, positive and negative aspects of surgical and radioactive iodine treatment. Is own stats of postoperative hyperparathyroidism. Is proposed to optimize the algorithm of actions in identifying thyroid nodules in children. In primary hyperparathyroidism, the emphasis is on the complexity of the postoperative management of patients related to the feature of childrens age in determining the severity of the reactions on the water-electrolyte disorders. Separately reviewed the literature of the adrenal glands diseases in children, demonstrating their own clinical cases which required surgical intervention. The authors describe the possibilities of modern neurosurgical equipment in the Endocrinology Research Centre in operations on the pituitary gland in children. Patients of different age groups performed transnasal transsphenoidal removal of tumors of the chiasm-sellar region using endoscopic assistance. The article also cited research data of pancreas diseases and their surgical treatment. Much attention is paid to the gender section of endocrine surgery in children. Discusses the tactics in disorders of sex development, gonadal tumors in children, diseases of the breast. In conclusion outlines the prospects for the development of endocrine surgery in children

    Analysis of Electric Vehicles Motion Modes Influence on Traction Batteries Aging Based on WLTC

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    Π’ Ρ€Π°Π±ΠΎΡ‚Π΅ рассмотрСны Ρ‚Π΅ΠΌΠΏΡ‹ роста элСктротранспортных срСдств с ΡƒΡ‡Π΅Ρ‚ΠΎΠΌ развития элСктрохимичСских Π½Π°ΠΊΠΎΠΏΠΈΡ‚Π΅Π»Π΅ΠΉ энСргии. ΠžΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Ρ‹ основныС ΠΌΠ΅Ρ…Π°Π½ΠΈΠ·ΠΌΡ‹ старСния Π»ΠΈΡ‚ΠΈΠ΅Π²Ρ‹Ρ… аккумуляторов Π² условиях Π½Π΅Ρ€Π°Π²Π½ΠΎΠΌΠ΅Ρ€Π½ΠΎΠΉ Π½Π°Π³Ρ€ΡƒΠ·ΠΊΠΈ ΠΈ с ΡƒΡ‡Π΅Ρ‚ΠΎΠΌ рСвСрсивного Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€Π° процСссов энСргообмСна с ΠΊΠΎΡ€ΠΎΡ‚ΠΊΠΈΠΌΠΈ Ρ€Π΅ΠΆΠΈΠΌΠ°ΠΌΠΈ подзаряда аккумуляторов ΠΏΡ€ΠΈ Ρ€Π΅ΠΊΡƒΠΏΠ΅Ρ€Π°Ρ‚ΠΈΠ²Π½ΠΎΠΌ Ρ‚ΠΎΡ€ΠΌΠΎΠΆΠ΅Π½ΠΈΠΈ. Для ΠΎΡ†Π΅Π½ΠΊΠΈ старСния Π»ΠΈΡ‚ΠΈΠ΅Π²ΠΎΠ³ΠΎ аккумулятора Π·Π° основу принят Π΅Π·Π΄ΠΎΠ²ΠΎΠΉ Ρ†ΠΈΠΊΠ» WLTC, Π² соотвСтствии с ΠΊΠΎΡ‚ΠΎΡ€Ρ‹ΠΌ Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Π»Π°ΡΡŒ Π½Π°Π³Ρ€ΡƒΠ·ΠΊΠ° Π½Π° Π±Π»ΠΎΠΊ Π½Π°ΠΊΠΎΠΏΠΈΡ‚Π΅Π»Π΅ΠΉ элСктромобиля. Π’ качСствС исслСдуСмого ΠΎΠ±Ρ€Π°Π·Ρ†Π° принят Nissan Leaf, оснащСнный Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹ΠΌΠΈ ΠΏΠΎ энСргоСмкости Π±Π»ΠΎΠΊΠ°ΠΌΠΈ Π½Π°ΠΊΠΎΠΏΠΈΡ‚Π΅Π»Π΅ΠΉ (БН). ΠŸΠΎΠ»ΡƒΡ‡Π΅Π½Ρ‹ для ΠΎΠ΄Π½ΠΎΠΉ аккумуляторной ячСйки Ρ‚ΠΎΠΊΠΎΠ²Ρ‹Π΅ Π΄ΠΈΠ°Π³Ρ€Π°ΠΌΠΌΡ‹, ΠΏΡ€ΠΈΠ²Π΅Π΄Π΅Π½Ρ‹ ΠΌΠΈΠ½ΠΈΠΌΠ°Π»ΡŒΠ½Ρ‹Π΅, срСдниС ΠΈ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡŒΠ½Ρ‹Π΅ Ρ‚ΠΎΠΊΠΈ, Π° Ρ‚Π°ΠΊΠΆΠ΅ Π΄Π»ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ Ρ€Π΅ΠΆΠΈΠΌΠΎΠ² тяги, тормоТСния ΠΈ остановки Π² Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… Ρ€Π΅ΠΆΠΈΠΌΠ°Ρ… управлСния элСктроподвиТного состава. Π‘Π΄Π΅Π»Π°Π½ΠΎ ΠΏΡ€Π΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ ΠΎ ростС энСргоСмкости БН Π² Π±ΡƒΠ΄ΡƒΡ‰Π΅ΠΌ ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Π΅ ΠΈ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΎ Π΅Π΅ влияниС Π½Π° Π½Π°Π³Ρ€ΡƒΠ·ΠΊΡƒ аккумуляторной Π±Π°Ρ‚Π°Ρ€Π΅ΠΈ (АБ). На основС ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠΉ ΠΎΠ±Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ Π΄Π°Π½Π½Ρ‹Ρ… выявлСны основныС измСнСния Π² ΠΏΡ€ΠΎΡ‚Π΅ΠΊΠ°ΡŽΡ‰ΠΈΡ… Π² энСргоустановкС процСссах, связанныС с ΡƒΠ²Π΅Π»ΠΈΡ‡Π΅Π½ΠΈΠ΅ΠΌ энСргоСмкости БНThe paper considers the growth rates of electric vehicles, taking into account the development of electrochemical energy storage. The main lithium batteries aging mechanisms under conditions of uneven load and reversible nature of energy exchange processes with short modes of recharging batteries during regenerative braking are determined. To assess the aging of the lithium battery, the WLTC driving cycle was taken as a basis, in accordance with which the load on the electric vehicle energy storage unit the was formed. A Nissan Leaf equipped with energy storage units (ESU) of different energy intensity was adopted as a test sample. Current diagrams were obtained for one battery cell, minimum, average and maximum currents, as well as durations of traction, braking and stopping modes in various control modes of electric rolling stock are given. An assumption is made about the growth of the energy intensity of the ESU in the future period and its influence on the load of the storage battery is determined. On the basis of the data processing carried out, the main changes in the processes occurring in the power source, associated with an increase in the energy intensity of the ESU, have been reveale

    Dinamika klyuchevykh mediatorov insulinorezistentnosti u bol'nykh sakharnym diabetom 2 tipa pri primenenii metformina (Formin Pliva?)

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    ЦСль. Π˜Π·ΡƒΡ‡Π΅Π½ΠΈΠ΅ влияния Ρ„ΠΎΡ€ΠΌΠΈΠ½Π° (ΠΌΠ΅Ρ‚Ρ„ΠΎΡ€ΠΌΠΈΠ½Π°) Π½Π΅ Ρ‚ΠΎΠ»ΡŒΠΊΠΎ Π½Π° состояниС ΡƒΠ³Π»Π΅Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ, Π½ΠΎ ΠΈ Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π°, Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΡƒ содСрТания Π»Π΅ΠΏΡ‚ΠΈΠ½Π°, Π΅Π³ΠΎ растворимого Ρ€Π΅Ρ†Π΅ΠΏΡ‚ΠΎΡ€Π° ΠΈ Π°Π»ΡŒΡ„Π°-Ρ„Π°ΠΊΡ‚ΠΎΡ€Π° Π½Π΅ΠΊΡ€ΠΎΠ·Π° ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ (Π°Π»ΡŒΡ„Π°-ЀНО) Π² сывороткС ΠΊΡ€ΠΎΠ²ΠΈ Ρƒ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… Π‘Π” 2. ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. ОбслСдовано 262 Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ…. ΠžΠ±Ρ‰ΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΊΡ€ΠΎΠ²ΠΈ ΠΈ ΠΌΠΎΡ‡ΠΈ ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Ρ‡Π΅Ρ€Π΅Π· ΠΊΠ°ΠΆΠ΄Ρ‹ΠΉ мСсяц наблюдСния, Π° биохимичСский Π°Π½Π°Π»ΠΈΠ· ΠΊΡ€ΠΎΠ²ΠΈ, Π²ΠΊΠ»ΡŽΡ‡Π°Ρ содСрТаниС ΠΎΠ±Ρ‰Π΅Π³ΠΎ Π₯Π‘, Π’Π“, Π₯Π‘ Π›ΠŸΠΠŸ ΠΈ Π›ΠŸΠžΠΠŸ ΠΈ Π₯Π‘ Π›ΠŸΠ’ΠŸ, ΠΌΠΎΡ‡Π΅Π²ΠΈΠ½Ρ‹, ΠΊΡ€Π΅Π°Ρ‚ΠΈΠ½ΠΈΠ½Π°, ΠΏΠ΅Ρ‡Π΅Π½ΠΎΡ‡Π½Ρ‹Ρ… Ρ„Π΅Ρ€ΠΌΠ΅Π½Ρ‚ΠΎΠ², ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π½Π° 1-ΠΌ ΠΈ 4-ΠΌ Π²ΠΈΠ·ΠΈΡ‚Π°Ρ…. Π›Π΅Ρ‡Π΅Π½ΠΈΠ΅ Ρ„ΠΎΡ€ΠΌΠΈΠ½ΠΎΠΌ ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΎΡΡŒ Π² Ρ‚Π΅Ρ‡Π΅Π½ΠΈΠ΅ Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ 12 Π½Π΅Π΄. ΠΈ ΠΈΠ·ΡƒΡ‡Π°Π»ΠΎΡΡŒ ΠΏΡ€ΠΈ этом Π΅Π³ΠΎ влияниС Π½Π° состояниС ΡƒΠ³Π»Π΅Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΈ Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° Ρƒ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… Π‘Π” 2. Из ΠΎΠ±Ρ‰Π΅Π³ΠΎ числа обслСдованных Ρƒ 26 Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… Π½Π° Ρ„ΠΎΠ½Π΅ Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ Ρ„ΠΎΡ€ΠΌΠΈΠ½ΠΎΠΌ ΠΈΠ·ΡƒΡ‡Π°Π»ΠΎΡΡŒ содСрТаниС Π»Π΅ΠΏΡ‚ΠΈΠ½Π°, растворимого Ρ€Π΅Ρ†Π΅ΠΏΡ‚ΠΎΡ€Π° ΠΊ Π»Π΅ΠΏΡ‚ΠΈΠ½Ρƒ ΠΈ Π°Π»ΡŒΡ„Π°-ЀНО. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. На Ρ„ΠΎΠ½Π΅ лСчСния Ρ„ΠΎΡ€ΠΌΠΈΠ½ΠΎΠΌ Ρƒ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… ΠΎΡ‚ΠΌΠ΅Ρ‡Π°Π»ΠΎΡΡŒ ΡƒΠ»ΡƒΡ‡ΡˆΠ΅Π½ΠΈΠ΅ ΡƒΠ³Π»Π΅Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π°, ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠ΅ ΡΠΎΠΏΡ€ΠΎΠ²ΠΎΠΆΠ΄Π°Π»ΠΎΡΡŒ статистичСски достовСрным сниТСниСм Π³Π»ΠΈΠΊΠ΅ΠΌΠΈΠΈ Π½Π°Ρ‚ΠΎΡ‰Π°ΠΊ. ΠšΠΎΠΌΠΏΠ΅Π½ΡΠ°Ρ†ΠΈΡ ΡƒΠ³Π»Π΅Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° Ρƒ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… Ρ‚Π°ΠΊΠΆΠ΅ ΡΠΎΠΏΡ€ΠΎΠ²ΠΎΠΆΠ΄Π°Π»Π°ΡΡŒ статистичСски достовСрным ΡƒΠΌΠ΅Π½ΡŒΡˆΠ΅Π½ΠΈΠ΅ΠΌ индСкса мас? сы Ρ‚Π΅Π»Π° с 34,02+0,33 ΠΊΠ³/ΠΌ2 Π΄ΠΎ 32,73+0,33 ΠΊΠ³/ΠΌ2. Π£ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… Π½Π° Ρ„ΠΎΠ½Π΅ лСчСния Ρ„ΠΎΡ€ΠΌΠΈΠ½ΠΎΠΌ Π½Π°Π±Π»ΡŽΠ΄Π°Π΅Ρ‚ΡΡ нСдостовСрноС сниТСниС содСрТания Π»Π΅ΠΏΡ‚ΠΈΠ½Π°, растворимого Ρ€Π΅Ρ†Π΅ΠΏΡ‚ΠΎΡ€Π° ΠΊ Π»Π΅ΠΏΡ‚ΠΈΠ½Ρƒ ΠΈ статистичСски достовСрноС сниТСниС Π°Π»ΡŒΡ„Π°-ЀНО Π² сывороткС ΠΊΡ€ΠΎΠ²ΠΈ. Π’Ρ‹Π²ΠΎΠ΄Ρ‹. ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Π½Ρ‹Π΅ исслСдования ΠΏΠΎΠΊΠ°Π·Ρ‹Π²Π°ΡŽΡ‚, Ρ‡Ρ‚ΠΎ Ρ„ΠΎΡ€ΠΌΠΈΠ½ ΠΎΠ±Π»Π°Π΄Π°Π΅Ρ‚ Π²Ρ‹Ρ€Π°ΠΆΠ΅Π½Π½Ρ‹ΠΌ антигипСргликСмичСским эффСктом, способствуСт ΡƒΠ»ΡƒΡ‡ΡˆΠ΅Π½ΠΈΡŽ компСнсации ΡƒΠ³Π»Π΅Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π°, Ρ‡Ρ‚ΠΎ сопровоТдаСтся статистичСски достовСрным сниТСниСм Π³Π»ΠΈΠΊΠ΅ΠΌΠΈΠΈ ΠΈ уровня Π³Π»ΠΈΠΊΠΎΠ·ΠΈΠ»ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π³Π΅ΠΌΠΎΠ³Π»ΠΎΠ±ΠΈΠ½Π° Π² сывороткС ΠΊΡ€ΠΎΠ²ΠΈ. Наряду с этим Π½Π° Ρ„ΠΎΠ½Π΅ Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ Ρ„ΠΎΡ€ΠΌΠΈΠ½ΠΎΠΌ отмСчаСтся сниТСниС уровня холСстСрина Π›ΠŸΠΠŸ ΠΈ ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΠ΅ содСрТания холСстСрина Π›ΠŸΠ’ΠŸ, ΠΏΡ€ΠΈ практичСски Π½Π΅ΠΈΠ·ΠΌΠ΅Π½Π΅Π½Π½Ρ‹Ρ… показатСлях содСрТания ΠΎΠ±Ρ‰Π΅Π³ΠΎ холСстСрина Π² сывороткС ΠΊΡ€ΠΎΠ²ΠΈ. ΠšΡ€ΠΎΠΌΠ΅ Ρ‚ΠΎΠ³ΠΎ, Π»Π΅Ρ‡Π΅Π½ΠΈΠ΅ Ρ„ΠΎΡ€ΠΌΠΈΠ½ΠΎΠΌ способствуСт статистичСски достовСрному сниТСнию содСрТания Π°Π»ΡŒΡ„Π°-ЀНО ΠΈ ΡƒΠΌΠ΅Ρ€Π΅Π½Π½ΠΎΠΌΡƒ пониТСнию уровня Π»Π΅ΠΏΡ‚ΠΈΠ½Π° ΠΈ Π΅Π³ΠΎ растворимого Ρ€Π΅Ρ†Π΅ΠΏΡ‚ΠΎΡ€Π° Π² сывороткС ΠΊΡ€ΠΎΠ²ΠΈ

    Primary hyperparathyroidism in young patients in Russia: high frequency of hyperparathyroidism-jaw tumor syndrome

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    Background: Primary hyperparathyroidism (PHPT) is a relatively rare disorder among children, adolescents and young adults. Its development at an early age is suspicious for hereditary causes, though the need for routine genetic testing remains controversial. Objective: To identify and describe hereditary forms of PHPT in patients with manifestation of the disease under 40Β years of age. Design: We enrolled 65 patients with PHPT diagnosed before 40Β years of age. Ten of them had MEN1 mutation, and PHPT in them was the first manifestation of multiple endocrine neoplasia type 1 syndrome. Methods: The other fifty-five patients underwent next-generation sequencing (NGS) of a custom-designed panel of genes, associated with PHPT (MEN1, CASR, CDC73, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2C, CDKN2D). In cases suspicious for gross CDC73 deletions multiplex ligation-dependent probe amplification was performed. Results: NGS revealed six pathogenic or likely pathogenic germline sequence variants: four in CDC73 c.271C>T (p.Arg91*), c.496C>T (p.Gln166*), c.685A>T (p.Arg229*) and c.787C>T (p.Arg263Cys); one in CASR c.3145G>T (p.Glu1049*) and one in MEN1 c.784-9G>A. In two patients, MLPA confirmed gross CDC73 deletions. In total, 44Β sporadic and 21 hereditary PHPT cases were identified. Parathyroid carcinomas and atypical parathyroid adenomas were present in 8/65 of young patients, in whom CDC73 mutations were found in 5/8. Conclusions: Hereditary forms of PHPT can be identified in up to 1/3 of young patients with manifestation of the disease at <40Β years of age. Parathyroid carcinomas or atypical parathyroid adenomas in young patients are frequently associated with CDC73 mutations

    State-of-Charge Estimation of Lithium-Ion Battery Based on Extended Kalman Filter Algorithm

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    ΠŸΡ€ΠΈ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠΈ уровня заряда (Π£Π—) накопитСля энСргии элСктричСского транспортного срСдства (Π­Π’Π‘) Π½Π° основС схСмы замСщСния Π»ΠΈΡ‚ΠΈΠΉ-ΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ аккумулятора (Π›Π˜Π) Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡŽΡ‚ Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Π΅ трудности. Π’Π°ΠΊ, для ΠΎΡ†Π΅Π½ΠΊΠΈ Π£Π— использован Ρ€Π°ΡΡˆΠΈΡ€Π΅Π½Π½Ρ‹ΠΉ Ρ„ΠΈΠ»ΡŒΡ‚Ρ€ Калмана (EKF, Extended Kalman filter). ΠœΠΎΠ΄Π΅Π»ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ ΡΠΊΡΠΏΠ΅Ρ€ΠΈΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½Ρ‹Π΅ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΠΏΠΎΠΊΠ°Π·Ρ‹Π²Π°ΡŽΡ‚, Ρ‡Ρ‚ΠΎ ΠΎΡ†Π΅Π½ΠΊΠ° Π£Π— ΠΌΠΎΠΆΠ΅Ρ‚ Π±Ρ‹Ρ‚ΡŒ Π²Ρ‹ΠΏΠΎΠ»Π½Π΅Π½Π° с использованиСм Π°Π»Π³ΠΎΡ€ΠΈΡ‚ΠΌΠ° EKF для Π΄ΠΎΡ€ΠΎΠΆΠ½Ρ‹Ρ… условий ΠΏΠΎ Ρ†ΠΈΠΊΠ»Ρƒ двиТСния Π² ΠšΠΈΡ‚Π°Π΅ (Chinacar) ΠΈ Π½ΠΎΠ²ΠΎΠΌΡƒ СвропСйскому Ρ†ΠΈΠΊΠ»Ρƒ (NEDC). По ΡΡ€Π°Π²Π½Π΅Π½ΠΈΡŽ с кулономСтричСским ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ срСдняя ошибка ΠΎΡ†Π΅Π½ΠΊΠΈ Π£Π— – 1,042 ΠΈ 1,138 % для Ρ†ΠΈΠΊΠ»ΠΎΠ² соотвСтствСнно, максимальная ошибка Π½Π΅ ΠΏΡ€Π΅Π²Ρ‹ΡˆΠ°Π΅Ρ‚ 4 %. ΠŸΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π°Π»Π³ΠΎΡ€ΠΈΡ‚ΠΌΠ° для опрСдСлСния Π£Π— ΠΈΠΌΠ΅Π΅Ρ‚ Π΄ΠΎΡΡ‚Π°Ρ‚ΠΎΡ‡Π½ΡƒΡŽ ΡƒΡΡ‚ΠΎΠΉΡ‡ΠΈΠ²ΠΎΡΡ‚ΡŒ ΠΈ ΡΡ…ΠΎΠ΄ΠΈΠΌΠΎΡΡ‚ΡŒAs the core component of electric vehicle, lithium-ion battery needs to adopt effective battery management method to prolong battery life and improve the reliability and safety. The accurate estimation of the battery SOC can be used to prevent the battery over charge and over discharge, reduce damage to the battery and improve battery performance, which plays a vital role in the battery management system. The study of battery SOC estimation mainly focused on the battery model construction and SOC estimation algorithm. Aiming at the problem that the state of charge (SOC) of electric vehicle is difficult to be accurately estimated under complex operating conditions, based on the parameter identification of the equivalent circuit of a ternary polymer lithium-ion battery, an Extended Kalman Filter (EKF) algorithm was used to estimate the SOC of the ternary polymer lithium-ion battery. Simulation and experimental results show that the estimation of SOC can be carried out by using the EKF algorithm under the conditions of China Passenger Car Condition (Chinacar) and new European driving cycle (NEDC) Compared with the coulomb counting method, the average error of SOC estimation can be realized is 1.042% and 1.138% respectively, the maximum error within 4%. Application of this algorithm to achieve SOC estimation has good robustness and convergenc

    Factors promoting development of renal tubulointerstitial lesions in patients with diabetes mellitus

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    Aim. To identify profibrogenic mediators, markers of endothelial dysfunction and hemostasis in patients with diabetes mellitus (DM) and chronickidney disease (CKD). Materials and methods. The study included 120 patients with DM and 20 age-matched normotensive subjects without DM showing the glomerularfiltration rate (GFR) > 60 ml/min/1.73 m3. Four groups of patients were distinguished: 1 - DM2 patients without renal pathology (n=33), 2 - DM2 patients with diabetic nephropathy (n=24), 3 - DM2 patients with ischemic nephropathy (IN) (n=33) verified by contrast visualization techniques(multispiral CM of abdominal aorta and renal arteries, abdominal angiography of renal arteries or MR angiography of renal arteries and abdominal aorta), 4 - DM1 patients with DN (n=30). Clinical examination included assessment of complaints, analysis of medical history of the main diseaseand concomitant disorders, determination of the main clinical and biochemical characteristics of blood and urine, measurement of НbА1с and 24-hralbuminuria (AU) by standard methods, estimation of GFR by the MDRD formula, ECG, echocardiography, 24-hr AP monitoring, counseling bycardiologist and ophthalmologist (fundal examination by ophthalmoscopy). Standard kits were used to detect profibrogenic mediators and markersof endothelial dysfunction including transforming growth factor-beta (TGF-b), angiotensin II (AT II), monocyte chemoattractant protein (MCP-1),regulated on activation normal T cell expressed and secreted (RANTES), adhesion factors (intracellular adhesion molecule (ICAM-1), vascular celladhesion molecule (VCAM-1) vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), asymmetric dimethylargnine (ADMA), homocysteine(HCYST), metalloproteinases (MMP), von Willebrand factor (vWF), plasminogen activator inhibitor (PAI-I). Results. DM patients with CKD had elevated blood profibrogenic cytokine (MCP-1, TGF-1b, IL-6) and extracellular matrix degradation factor(MMP-9) levels compared with patients without CKD and healthy subjects. These changes were unrelated to the type of diabetes or the cause ofnephropathy, which suggests their contribution to renal pathology through the universal mechanism of tubulointerstitial fibrosis. Activation of profibrogeniccytokines in DM patients with CKD was closely associated with endothelial dysfunction manifest as enhanced production of blood adhesive angiogenic, thrombogenic factors (FW, PAI, VICAM, sICAM, VEGF), and endothelium-affecting factors (ADMA, homocysteine). Mediators of inflammationand fibrogenesis in these patients negatively correlated with GFR and positively with AU, the main markers of renal dysfunction. Hyperuricemia,TGF-1b, ADMA, and MCP-1 are considered to be the risk factors of impaired renal filtration function. Conclusion. The level of profibrogenic cytokines and ndothelial dysfunction factors in DM patients with different renal lesions reflects severity of tubulointerstitialfibrosis. It may be used for the purpose of prognostication and substantiation of intensification of secondary prophylaxis of renal insufficiency
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