Crush injuries and crush syndrome -a review. Part 2: the local injury

Crush injuries can occur in considerable numbers following natural disasters or acts of war and terrorism. They can also occur sporadically after industrial accidents or following periods of unconsciousness from drug intoxication, anaesthesia, trauma or cerebral events. A common pathophysiological pathway has been elucidated over the last century describing traumatic rhabdomyolysis leading to myoglobinuric acute renal failure and a systemic 'crush syndrome' affecting many organ systems. If left unrecognised or untreated then mortality rates are high. If treatment is commenced early and the systemic effects are minimised then patients are often faced with significant morbidity from the crushed limbs themselves. We have performed a thorough review of the English language literature from 1940-2009 investigating crush injuries and crush syndrome and present a comprehensive, two-part summary. Part 1: The systemic injury, we concentrate on the systemic crush syndrome. We determine the pathophysiology, clinical and prognostic indicators and treatment options such as forced alkaline diuresis, mannitol therapy, dialysis and haemofiltration. We discuss more controversial treatment options such as allopurinol, potassium binders, calcium therapy and other diuretics. We also discuss the specific management issues of the secondary 'renal disaster' that can occur following earthquakes and other mass disasters. Part 2: The local injury, we look in more detail at the pathophysiology of skeletal muscle damage following crush injuries and discuss how to minimise morbidity by salvaging limb function. In particular we discuss the controversies surrounding fasciotomy of crushed limbs and compare surgical management with conservative techniques such as mannitol therapy, hyperbaric oxygen therapy, topical negative pressure therapy and a novel topical treatment called gastric pentadecapeptide BPC 157

Sporting and physical activity following hip resurfacing

The aim of this study was to assess sporting and physical activities in patients who had undergone hip resurfacing. Our study included 117 patients who underwent hip resurfacing between 2003 and 2008. University of California at Los Angeles (UCLA) activity level and Oxford hip scores (OHS) were used. Sporting and physical activities of all patients were analysed pre- and postoperatively. The mean age at surgery was 54 years. The mean follow up was 30 months. There was statistically significant improvement in UCLA activity scores from 4.4 to 6.8 (p < 0.05) and Oxford hip scores from 43.4 to 17.7 following surgery. Eighty-seven percent of patients continued to take part in sporting activities following hip resurfacing. Our study has demonstrated that hip resurfacing can allow patients to remain extremely active