12 research outputs found
Outcome of breast cancer screening in Denmark
Abstract Background In Denmark, national roll-out of a population-based, screening mammography program took place in 2007–2010. We report on outcome of the first four biennial invitation rounds. Methods Data on screening outcome were retrieved from the 2015 and 2016 national screening quality reports. We calculated coverage by examination; participation after invitation; detection-, interval cancer- and false-positive rates; cancer characteristics; sensitivity and specificity, for Denmark and for the five regions. Results At the national level coverage by examination remained at 75–77%; lower in the Capital Region than in the rest of Denmrk. Detection rate was slightly below 1% at first screen, 0.6% at subsequent screens, and one region had some fluctuation over time. Ductal carcinoma in situ (DCIS) constituted 13–14% of screen-detected cancers. In subsequent rounds, 80% of screen-detected invasive cancers were node negative and 40% ≤10 mm. False-positive rate was around 2%; higher for North Denmark Region than for the rest of Denmark. Three out of 10 breast cancers in screened women were diagnosed as interval cancers. Conclusions High coverage by examination and low interval cancer rate are required for screening to decrease breast cancer mortality. Two pioneer local screening programs starting in the 1990s were followed by a decrease in breast cancer mortality of 22–25%. Coverage by examination and interval cancer rate of the national program were on the favorable side of values from the pioneer programs. It appears that the implementation of a national screening program in Denmark has been successful, though regional variations need further evaluation to assure optimization of the program
Additional file 4: Table S4. of Outcome of breast cancer screening in Denmark
Number of screen-detected cancers (Invasive + DCIS), screen-detected cancers (invasive only) and interval cancers (invasive only) by invitation round and region in screening mammography in Denmark 2008â 2015. (DOCX 15Â kb
Additional file 1: Table S1. of Outcome of breast cancer screening in Denmark
Date of start and foreseen date of end of invitations rounds by region and length (in months) of invitation round. (DOCX 12Â kb
Additional file 3: Table S3. of Outcome of breast cancer screening in Denmark
Number of screened women, recalled women, screen-detected breast cancers (incl. DCIS) and women with false positive screen by invitation round and region in screening mammography in Denmark, 2008â 2015. (DOCX 15Â kb
Additional file 5: Table S5. of Outcome of breast cancer screening in Denmark
Number of screened women, screen-detected cancers (invasive + DCIS) interval cancers and women with false positive screens by invitations round and region in screening mammography in Denmark 2008–2015. (DOCX 15 kb
Additional file 2: Table S2. of Outcome of breast cancer screening in Denmark
Number of women in target population, invited women and screened women by invitation round and region in screening mammography, Denmark 2008â 2015. (DOCX 15Â kb
Outcome of breast cancer screening in Denmark
Abstract Background In Denmark, national roll-out of a population-based, screening mammography program took place in 2007–2010. We report on outcome of the first four biennial invitation rounds. Methods Data on screening outcome were retrieved from the 2015 and 2016 national screening quality reports. We calculated coverage by examination; participation after invitation; detection-, interval cancer- and false-positive rates; cancer characteristics; sensitivity and specificity, for Denmark and for the five regions. Results At the national level coverage by examination remained at 75–77%; lower in the Capital Region than in the rest of Denmrk. Detection rate was slightly below 1% at first screen, 0.6% at subsequent screens, and one region had some fluctuation over time. Ductal carcinoma in situ (DCIS) constituted 13–14% of screen-detected cancers. In subsequent rounds, 80% of screen-detected invasive cancers were node negative and 40% ≤10 mm. False-positive rate was around 2%; higher for North Denmark Region than for the rest of Denmark. Three out of 10 breast cancers in screened women were diagnosed as interval cancers. Conclusions High coverage by examination and low interval cancer rate are required for screening to decrease breast cancer mortality. Two pioneer local screening programs starting in the 1990s were followed by a decrease in breast cancer mortality of 22–25%. Coverage by examination and interval cancer rate of the national program were on the favorable side of values from the pioneer programs. It appears that the implementation of a national screening program in Denmark has been successful, though regional variations need further evaluation to assure optimization of the program