Form factors and differential distributions in rare radiative leptonic B-decays

We study rare radiative leptonic decays $B_{(s)}\to e^+e^-\gamma$ and $B_{(s)}\to \mu^+\mu^-\gamma$ within relativistic quark model. In addition to previous analysis we give the estimations of the branching ratios for four values of the minimal photon energy, which correspond to photon selection criteria of the Belle and LHCb detectors. We find out that the branching ratios only slightly change. The highest values corresponding to $E^\gamma_{min}=80 \textrm{MeV}$ are ${\cal B}(\bar B^0_s\to e^+e^-\gamma)=18.5\times10^{-9}$ and ${\cal B}(B^0_s\to \mu^+\mu^-\gamma)=11.9\times10^{-9}$. We present the distribution of the forward-backward asymmetry.Comment: 9 pages, 8 figures, Talk given at XII Quark Confinement and the Hadron Spectrum, August 29 -- September 3, 2016, Thessaloniki, Greece. arXiv admin note: substantial text overlap with arXiv:1609.0649

Rare radiative leptonic B-decays

We obtain predictions for $B_{(s)}\to e^+e^-\gamma$ and $B_{(s)}\to \mu^+\mu^-\gamma$ decays. All the contributions containing long-distance QCD effects are calculated in the framework of relativistic quark model. The contributions of the light vector-meson resonances related to the virtual photon emission from valence quarks of the $B$-meson are included. The highest branching ratios for the radiative leptonic B-decays are ${\cal B}(\bar B^0_s\to e^+e^-\gamma)=18.8\times10^{-9}$ and ${\cal B}(B^0_s\to \mu^+\mu^-\gamma)=12.2\times10^{-9}$. We also give the distribution of the foward-backward asymmetry.Comment: 8 pages, 11 figures, talk given at the 19th International Seminar on High Energy Physics QUARKS-2016, Pushkin, Russia, 29 May - 4 June, 201

Long-distance QCD effects in FCNC B→γl+l−B\to \gamma l^+l^- decays

This presentation reviews the main results of our recent work [A.K., D.M., N.N., Phys. Rev. D97, 053007 (2018)] on rare radiative leptonic decays $B_{d,s}\to\gamma\mu^+\mu^-$ and $B_{d,s}\to\gamma e^+e ^-$ induced by flavour-changing neutral currents (FCNC) in the Standard Model.Comment: 5 pages, contributed to "QCD@Work 2018 - International Workshop on Quantum Chromodynamics: Theory and Experiment" (25 - 28 June 2018, Matera, Italy

Rare radiative leptonic decays B_{d,s}-> l^+l^-\gamma

Long-distance QCD effects in $B_{d,s}\to\ell^+\ell^-\gamma$ decays are analyzed. We show that the contribution of the light vector-meson resonances related to the virtual photon emission from valence quarks of the $B$-meson, which was not considered in previous analyses, strongly influences the dilepton differential distrubution. Taking into account photon emission from the $b$-quark loop, weak annihilation, and Bremsstrahlung from leptons in the final state, we give predictions for dilepton spectrum in $B_{d, s}\to \ell^+\ell^-\gamma$ decays within the Standard model.Comment: 8 pages, typoes corrected, replaced with the version to appear in Physical Review

Forward-backward and CP-violating asymmetries in rare B_{d,s}\to (V,\gamma) l^+l^- decays

We study the forward-backward and the CP-violating asymmetries (both time-independent and time-dependent) in rare semileptonic $B_d\to\rho^0 l^+l^-$, $B_s\to\phi l^+l^-$, and radiative leptonic $B_{d,s}\to \gamma l^+l^-$ decays and investigate the sensitivity of these asymmetries to the extensions of the Standard model.Comment: Revised version: plots for A_CP corrected, discussion of B_d\to \rho^0 l^+l^- adde

Hydrocortisone concentration influences time to clinically significant healing of acute inflammation of the ocular surface and adnexa – results from a double-blind randomized controlled trial

BACKGROUND: The efficacy of topical ophthalmic corticosteroids depends upon small modifications in preparations, such as drug concentration. The aim of this study was to confirm that hydrocortisone acetate (HC-ac) ophthalmic ointments of 2.5% and 1% are more effective than a 0.5% eye ointment. METHODS: In this randomized, double-blind, placebo-controlled, parallel-group clinical study, the change of signs and symptoms of acute inflammation of the ocular surface and adnexa was evaluated in 411 subjects. RESULTS: Median time to clinically relevant response as estimated by 50% reduction in clinical signs and symptoms (CSS) total score over the entire trial was similar for subjects treated with HC-ac 2.5% (73.5 h) and for subjects treated with HC-ac 1.0% (67.7 h) and was considerably and significantly longer for subjects treated with HC-ac 0.5% (111.8 h) [p < 0.001 for both dosages]. All trial medications were safe and well tolerated. CONCLUSION: Hydrocortisone acetate 2.5% and Hydrocortisone acetate 1% eye ointments are efficacious and safe treatments for acute inflammations of the ocular surface or adnexa, and showed significantly better efficacy than a control group treated with Hydrocortisone acetate 0.5% therapy. TRIAL REGISTRATION: Current Controlled Trials ISRCTN15464650

Automatic pathway building in biological association networks

BACKGROUND: Scientific literature is a source of the most reliable and comprehensive knowledge about molecular interaction networks. Formalization of this knowledge is necessary for computational analysis and is achieved by automatic fact extraction using various text-mining algorithms. Most of these techniques suffer from high false positive rates and redundancy of the extracted information. The extracted facts form a large network with no pathways defined. RESULTS: We describe the methodology for automatic curation of Biological Association Networks (BANs) derived by a natural language processing technology called Medscan. The curated data is used for automatic pathway reconstruction. The algorithm for the reconstruction of signaling pathways is also described and validated by comparison with manually curated pathways and tissue-specific gene expression profiles. CONCLUSION: Biological Association Networks extracted by MedScan technology contain sufficient information for constructing thousands of mammalian signaling pathways for multiple tissues. The automatically curated MedScan data is adequate for automatic generation of good quality signaling networks. The automatically generated Regulome pathways and manually curated pathways used for their validation are available free in the ResNetCore database from Ariadne Genomics, Inc. [1]. The pathways can be viewed and analyzed through the use of a free demo version of PathwayStudio software. The Medscan technology is also available for evaluation using the free demo version of PathwayStudio software