6 research outputs found
Stability of cell-penetrating peptide anti-VEGF formulations for the treatment of age-related macular degeneration
Developing novel biointerfaces:using chlorhexidine surface attachment as a method for creating anti-fungal surfaces
There is an increasing focus in healthcare environments on combatting antimicrobial resistant infections. While bacterial infections are well reported, infections caused by fungi receive less attention, yet have a broad impact on society and can be deadly. Fungi are eukaryotes with considerable shared biology with humans, therefore limited technologies exist to combat fungal infections and hospital infrastructure is rarely designed for reducing microbial load. In this study, a novel antimicrobial surface (AMS) that is modified with the broadâspectrum biocide chlorhexidine is reported. The surfaces are shown to kill the opportunistic fungal pathogens Candida albicans and Cryptococcus neoformans very rapidly (<15 min) and are significantly more effective than current technologies available on the commercial market, such as silver and copper
Directly bonding antimicrobial peptide mimics to steel and the real world applications of these materials
Development of biocide coated polymers and their antimicrobial efficacy
Microbial contamination of plastic surfaces is a significant source of hospitalâacquired infections. To produce antimicrobial surfaces, chlorhexidine was attached to nitrided acrylonitrile butadiene styrene (ABS). The uniformity of chlorhexidine distribution on the plastic surfaces was revealed by timeâofâflight secondary ion mass spectrometry (TOFâSIMS) imaging. Its antimicrobial efficacy was established against model pathogenic Gramâpositive and Gramânegative bacteria, fungi, and viruses. The stability of the bonded chlorhexidine was evaluated via a leaching test. The surfaces rapidly killed microbes: no viable colonies of Escherichia coli, Staphylococcus aureus, or Candida albicans were recoverable after 45 minutes. It was effective against SARSâCOVâ2, with no viable virions found after 30 minutes. Additionally, the surfaces were as effective in killing chlorhexidineâresistant strains of bacteria as they were in killing naĂŻve strains. The surface was stable; after 2 weeks of leaching, no detectable chlorhexidine was found in the leachate. We believe that the technology is widely applicable to prevent the spread of fomite infection