This paper estimates the economic impact of climate change on road infrastructure using the stressor-response methodology. Our analysis indicates that it could cumulatively (2020–2100) cost Ghana 473milliontomaintainandrepairdamagescausedtoexistingroadsasaresultofclimatechange(noadaptscenario).However,ifthecountryadaptsthedesignandconstructionofnewroadinfrastructure,expectedtooccurovertheasset’slifespan(adaptscenario),thetotalcumulativecostcouldincreaseto678.47 million due to the initial costs of adaptation. This investment provides lower costs on a decadal basis later in the infrastructure lifespan. This creates the planning question of whether lower decadal costs in the future are a priority or if minimizing initial costs is a priority. The paper addresses this question through decadal and average annual costs up to the year 2100 for the ten regions, using the potential impacts of 54 distinct potential climate scenarios