732 research outputs found
Computing the Tutte Polynomial of a Matroid from its Lattice of Cyclic Flats
We show how the Tutte polynomial of a matroid can be computed from its
condensed configuration, which is a statistic of its lattice of cyclic flats.
The results imply that the Tutte polynomial of is already determined by the
abstract lattice of its cyclic flats together with their cardinalities and
ranks. They furthermore generalize a similiar statement for perfect matroid
designs due to Mphako and help to understand families of matroids with
identical Tutte polynomial as constructed by Ken Shoda.Comment: New version published in: Electronic Journal Of Combinatorics Volume
21, Issue 3 (2014)
http://www.combinatorics.org/ojs/index.php/eljc/article/view/v21i3p4
The timing and magnitude of exchange rate overshooting
Empirical evidence suggests that a monetary shock induces the exchange rate to overshoot its long-run level. The estimated magnitude and timing of the overshooting, however, varies across studies. This paper generates delayed overshooting in a new Keynesian model of a small open economy by incorporating incomplete information about the true nature of the monetary shock. The framework allows for a sensitivity analysis of the overshooting result to underlying structural parameters. It is shown that policy objectives and measures of the economy's sensitivity to exchange rate dynamic affect the timing and magnitude of the overshooting in a predictable manner, suggesting a possible rationale for the cross-study variation of the delayed overshooting Phenomenon. --Exchange rate overshooting,Partial information,Learning
K-theory Soergel Bimodules
We initiate the study of K-theory Soergel bimodules-a K-theory analog of
classical Soergel bimodules. Classical Soergel bimodules can be seen as a
completed and infinitesimal version of their new K-theoretic analog. We show
that morphisms of K-theory Soergel bimodules can be described geometrically in
terms of equivariant K-theoretic correspondences between Bott-Samelson
varieties. We thereby obtain a natural categorification of K-theory Soergel
bimodules in terms of equivariant coherent sheaves. We introduce a formalism of
stratified equivariant K-motives on varieties with an affine stratification,
which is a K-theoretric analog of the equivariant derived category of
Bernstein-Lunts. We show that Bruhat-stratified torus-equivariant K-motives on
flag varieties can be described in terms of chain complexes of K-theory Soergel
bimodules. Moreover, we propose conjectures regarding an equivariant/monodromic
Koszul duality for flag varieties and the quantum K-theoretic Satake
K-Motives and Koszul Duality
We construct an \emph{ungraded version} of Beilinson--Ginzburg--Soergel's
Koszul duality, inspired by Beilinson's construction of rational motivic
cohomology in terms of -theory. For this, we introduce and study the
category of constructible -motives on varieties with an affine
stratification. There is a natural and geometric functor from the category of
mixed sheaves to We show that when is the flag
variety, this functor is Koszul dual to the realisation functor from
to , the constructible derived category
A mechanistic framework for a priori pharmacokinetic predictions of orally inhaled drugs
The fate of orally inhaled drugs is determined by pulmonary pharmacokinetic
(PK) processes such as particle deposition, pulmonary drug dissolution, and
mucociliary clearance. Although each single process has been systematically
investigated, a quantitative understanding on their interaction remains limited
and hence identifying optimal drug and formulation characteristics for orally
inhaled drugs is still challenging. To investigate this complex interplay, the
pulmonary processes can be integrated into mathematical models. However,
existing modeling attempts considerably simplify these processes or are not
systematically evaluated against (clinical) data. In this work, we developed a
mathematical framework based on physiologically-structured population equations
to integrate all relevant pulmonary processes mechanistically. A tailored
numerical resolution strategy was chosen and the mechanistic model was
evaluated systematically against different clinical datasets. Without any
parameter estimation based on individual study data, the developed model
simultaneously predicted (1) lung retention profiles of inhaled insoluble
particles, (2) particle size-dependent PK of inhaled monodisperse particles,
(3) PK differences between inhaled fluticasone propionate and budesonide, and
(4) PK differences between healthy volunteers and asthmatic patients. Finally,
to identify the most impactful optimization criteria for orally inhaled drugs,
we investigated the impact of input parameters on both pulmonary and systemic
exposure. Solubility of the inhaled drug did not have any relevant impact on
local and systemic PK. Instead, pulmonary dissolution rate, particle size,
tissue affinity, and systemic clearance were impactful potential optimization
parameters. In the future, the developed prediction framework should be
considered a powerful tool to identify optimal drug and formulation
characteristics
Evaluation of sampling and quenching procedures for the analysis of intracellular metabolites in CHO suspension cells
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