Experimental validation of a truck roll model using asynchronous measurements with low signal-to-noise ratios

There is a large body of literature on model validation, but there is no method available that can effectively use asynchronous repeated measurements with low signal-to-noise ratios. The aim of this paper is to present a novel frequency-domain model validation method, which is suitable for this type of measurements. The practical relevance of the validation problem is demonstrated by means of a 4-DOF roll model, representing the front dynamics of a tractor semi-trailer system (heavy-duty truck), which is confronted with a large set of measurement data obtained from various experimental driving tests. The validation method is successfully used. It is concluded that the roll model gives a reasonably accurate description of the front roll dynamics, although the model is relatively uncertain around the cabin resonance frequency. The proposed validation method is considered to be a valuable tool to objectively evaluate the quality of vehicle models

The Effect of a Structured Medication Review on Quality of Life in Parkinson's Disease

Background: Drug therapy is important for controlling symptoms in Parkinson's disease (PD). However, it often results in complex medication regimens and could easily lead to drug related problems (DRP), suboptimal adherence and reduced treatment efficacy. A structured medication review (SMR) could address these issues and optimize therapy, although little is known about clinical effects in PD patients. Objective: To analyze whether an SMR improves quality of life (QoL) in PD. Methods: In this multicenter randomized controlled trial, half of the 202 PD patients with polypharmacy received a community pharmacist-led SMR. The control group received usual care. Assessments at baseline, and after three and six months comprised six validated questionnaires. Primary outcome was PD specific QoL [(PDQ-39; range 0 (best QoL) - 100 (worst QoL)]. Secondary outcomes were disability score, non-motor symptoms, general health status, and personal care giver's QoL. Furthermore, DRPs, proposed interventions, and implemented modifications in medication schedules were analyzed. Results: No improvement in QoL was seen six months after an SMR, with a non-significant treatment effect difference of 2.09 (-0.63;4.80) in favor of the control group. No differences were found in secondary outcomes. In total, 260 potential DRPs were identified (2.6 (±1.8) per patient), of which 62% led to drug therapy optimization. Conclusion: In the current setting, a community pharmacist-led SMR did not improve QoL in PD patients, nor improved other pre-specified outcomes