Intellectual and motor development of young adults with congenital hypothyroidism diagnosed by neonatal screening

Contains fulltext : 35756.pdf (publisher's version ) (Open Access)CONTEXT: Long-term follow-up data on cognitive and motor functioning in adult patients with congenital hypothyroidism, diagnosed by neonatal screening, are scarce. Hence, it is still unclear whether the frequently reported cognitive and motor deficits observed during childhood persist in adulthood. OBJECTIVE: The objective of this study was to examine cognitive and motor functioning in young adults with congenital hypothyroidism, born in the first 2 yr after the introduction of the Dutch neonatal screening program. DESIGN/SETTING/PATIENTS: Seventy patients were tested (mean age, 21.5 yr); 49 of them were previously tested at 9.5 yr. The median age at the start of treatment was 28 d (range, 4-293 d). Congenital hypothyroidism was classified as severe, moderate, or mild, according to pretreatment T(4) concentrations. MAIN OUTCOME MEASUREMENT: The main outcome measurement was the influence of the severity of congenital hypothyroidism and age at which T(4) supplementation was started on cognitive and motor outcome. RESULTS: Patients, particularly those with severe congenital hypothyroidism, had significantly higher (i.e. worse) motor scores (total score, 7.8; ball skills, 2.0; balance, 4.1) compared with controls (total score, 3.2; ball skills, 0.7; balance, 1.1), and lower full-scale (95.8), verbal (96.4), and performance (95.6) intelligence quotient (IQ) scores than the normal population. No significant change in IQ from childhood to adulthood was found, and for the majority of patients, motor score classification remained the same. The severity of congenital hypothyroidism, but not the starting day of treatment, was correlated with IQ and motor scores. CONCLUSIONS: It is concluded that the severity of congenital hypothyroidism, but not the timing of treatment initiation, is an important factor determining long-term cognitive and motor outcome. Clearly, detrimental effects on developmental outcome in patients with congenital hypothyroidism persist over time

Guideline-based development and practice test of quality indicators for physiotherapy care in patients with neck pain.

Epub ahead of prin

Corrigendum to “Effects of physical therapy for temporomandibular disorders on headache pain intensity: A systematic review” (Musculoskeletal Science and Practice (2020) 50, (102277), (S2468781220305828), (10.1016/j.msksp.2020.102277))

© 2021 The Author(s)The authors regret that the original paper had some omissions, and are thankful for the opportunity to present corrections in this corrigendum. The conclusion in the abstract and paper should state that physical therapy interventions presented a small, but not significant, effect on reducing headache pain intensity in subjects with TMD, with a low level of certainty. Secondly, the Risk of Bias figures were not matching the text, and therefore should be replaced by the correct figures as below: Fig. 2. Risk of Bias graph (corrected

Reply to ‘letter to the editor concerning ‘effects of physical therapy for temporomandibular disorders on headache pain intensity: A systematic review’ by Castien & Scholten-Peeters

Contains fulltext : 235057.pdf (Publisher’s version ) (Closed access)01 juni 202