The structures of depictive and resultative constructions in chinese

In this paper I firstly argue that secondary predicates are complement of v, and v is overtly realized by Merge or Move in secondary predication in Chinese. The former option derives the de-construction, whereas the latter option derives the V-V construction. Secondly, I argue that resultatives are hosted by complement vPs, whereas depictives are hosted by adjunct vPs. This complement-adjunct asymmetry accounts for a series of syntactic properties of secondary predication in Chinese: the position of a secondary predicate with respect to the verb of the primary predicate, the co-occurrence patterns of secondary predicates, the hierarchy of depictives, the control and ECM properties of resultative constructions, and the locality constraint on the integration of secondary predicates into the structure of primary predication. Thirdly, I argue that the surface position of de is derived by a PF operation which attaches de to the right of the leftmost verbal lexical head of the construction. Finally, I argue that in the V-V resultative construction, the assumed successive head-raising may account for the possible subject-oriented reading of the resultative predicate, and that the head raising out of the lower vP accounts for the possible non-specific reading of the subject of the resultative predicate

On nonprimary selectional restrictions

This paper argues for non-primary c- and s-selectional restrictions of verbs in computing nonprimary predicatives such as resultatives, depictives, and manners. Our discussion is based both on the selection violations in the presence of nonprimary predicates and on the cross-linguistic and language-internal variations of categorial and semantic constraints on nonprimary predicates. We claim that all types of thematic predication are represented by an extended projection, and that the merger of lexical heads with another element, regardless of the type of the element, consistently has c- and s-selectional restrictions

Proceedings of the workshop on Syntax of Predication, Nov 2-3, 2001, ZAS-Berlin / Edited by Niina Zhang

This volume presents working versions of presentations heard at and selected for the Workshop on Syntax of Predication, held at ZAS, Berlin, on November 2-3, 2001 (except the editor’s own paper). Predication is a many-faceted topic which involves both syntax and semantics and the interface between them. This is reflected in the papers of the volume

Empty verbs in Chinese predicatives and complex predicates

This paper investigates syntactic properties of verbless constructions in Chinese. Verbless constructions differ from constructions with overt verbs in three major respects. First, there is a VP-internal nominal raising in Chinese, which is optional if an overt verb shows up, and obligatory if there is no overt verb. Second, while an overt verb can select various kinds of argument, the internal argument of a verbless construction cannot be indefinite. Third, there are two types of object depictive secondary predication constructions, and only one of them allows for a null verb

A Targeted Multiomics Approach to Identify Biomarkers Associated with Rapid eGFR Decline in Type 1 Diabetes

Background: Individuals with type 1 diabetes (T1D) demonstrate varied trajectories of estimated glomerular filtration rate (eGFR) decline. The molecular pathways underlying rapid eGFR decline in T1D are poorly understood, and individual-level risk of rapid eGFR decline is difficult to predict. Methods: We designed a case-control study with multiple exposure measurements nested within 4 well-characterized T1D cohorts (FinnDiane, Steno, EDC, and CACTI) to identify biomarkers associated with rapid eGFR decline. Here, we report the rationale for and design of these studies as well as results of models testing associations of clinical characteristics with rapid eGFR decline in the study population, upon which "omics" studies will be built. Cases (n = 535) and controls (n = 895) were defined as having an annual eGFR decline of >= 3 andPeer reviewe

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans

A carbohydrate-restricted diet is a widely recommended intervention for non-alcoholic fatty liver disease (NAFLD), but a systematic perspective on the multiple benefits of this diet is lacking. Here, we performed a short-term intervention with an isocaloric low-carbohydrate diet with increased protein content in obese subjects with NAFLD and characterized the resulting alterations in metabolism and the gut microbiota using a multi-omics approach. We observed rapid and dramatic reductions of liver fat and other cardiometabolic risk factors paralleled by (1) marked decreases in hepatic de novo lipogenesis; (2) large increases in serum beta-hydroxybutyrate concentrations, reflecting increased mitochondrial beta-oxidation; and (3) rapid increases in folate-producing Streptococcus and serum folate concentrations. Liver transcriptomic analysis on biopsy samples from a second cohort revealed downregulation of the fatty acid synthesis pathway and upregulation of folate-mediated one-carbon metabolism and fatty acid oxidation pathways. Our results highlight the potential of exploring diet-microbiota interactions for treating NAFLD.Peer reviewe

Evaluation of Methods for De Novo Genome Assembly from High-Throughput Sequencing Reads Reveals Dependencies That Affect the Quality of the Results

Recent developments in high-throughput sequencing technology have made low-cost sequencing an attractive approach for many genome analysis tasks. Increasing read lengths, improving quality and the production of increasingly larger numbers of usable sequences per instrument-run continue to make whole-genome assembly an appealing target application. In this paper we evaluate the feasibility of de novo genome assembly from short reads (≤100 nucleotides) through a detailed study involving genomic sequences of various lengths and origin, in conjunction with several of the currently popular assembly programs. Our extensive analysis demonstrates that, in addition to sequencing coverage, attributes such as the architecture of the target genome, the identity of the used assembly program, the average read length and the observed sequencing error rates are powerful variables that affect the best achievable assembly of the target sequence in terms of size and correctness

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm birth in 84,689 infants. One locus on chromosome 2q13 is associated with gestational duration; the association is replicated in 9,291 additional infants (combined P= 3.96 x 10(-14)). Analysis of 15,588 mother-child pairs shows that the association is driven by fetal rather than maternal genotype. Functional experiments show that the lead SNP, rs7594852, alters the binding of the HIC1 transcriptional repressor. Genes at the locus include several interleukin 1 family members with roles in pro-inflammatory pathways that are central to the process of parturition. Further understanding of the underlying mechanisms will be of great public health importance, since giving birth either before or after the window of term gestation is associated with increased morbidity and mortality.Peer reviewe