Studies of Ground water quality assessment at industrial belt of Kashipur, Uttarakhand, India

Pollution of ground water is one of the areas of major concern to environmentalists. Water quality is an index of health and well being of a society. Industrialisation, urbanisation and modern agriculture practices have direct impact on ground water resources. These factors influence the ground water quantitatively and qualitatively. Ground water is an important source of potable water supply for Kashipur as well as adjoined areas of the U S Nagar district for all purposes. Ten different locations were selected for the study and compared. Attempts were made to study and analyze the physico-chemical characteristics of the water. The parameters studied were temperature, pH, total alkalinity, total hardness, chloride, sulphate, total dissolved solids, calcium, magnesium and conductivity. By observing the result it can be concluded that the parameters which were taken for study the water quality are below the pollution level for ground water which satisfy the requirement for the use of various purposes like domestic, agricultural, industrial etc in Kashipur area

Studies of surfacewater quality of the Kashipur, Uttarakhand, India

Pollution of water bodies is one of the areas of major concern to environmentalists. Water quality is an index of health and well being of a society. Industrialisation, urbanisation and modern agriculture practices have direct impact on water resources. These factors influence the water resources quantitatively and qualitatively. The study area selected were the Bahella river, Mahadev stream and Kosi river basin of Kashipur, Uttarakhand, India. The Bahellariver, Mahadev and Kosi river water is an important source of potable water supply for Kashipur as well as adjointed areas of the U S Nagar district for all purposes.The physico-chemical parameters like temperature, pH, turbidity, total hardness, alkalinity, BOD, COD, chloride, nitrate and phosphate and fluoride content in water of Bahella river, Mahadev stream and Kosi river were studied to ascertain the drinking and domestic as well as irrigation water supply in Kashipur area. In this present study water quality of Bahellariver, Mahadev stream and Kosi river is taken into account and Khokartalwater is found to be severely polluted with reference to these analyzed parameters

Evasion of anti-growth signaling: a key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds

The evasion of anti-growth signaling is an important characteristic of cancer cells. In order to continue to proliferate, cancer cells must somehow uncouple themselves from the many signals that exist to slow down cell growth. Here, we define the anti-growth signaling process, and review several important pathways involved in growth signaling: p53, phosphatase and tensin homolog (PTEN), retinoblastoma protein (Rb), Hippo, growth differentiation factor 15 (GDF15), AT-rich interactive domain 1A (ARID1A), Notch, insulin-like growth factor (IGF), and Krüppel-like factor 5 (KLF5) pathways. Aberrations in these processes in cancer cells involve mutations and thus the suppression of genes that prevent growth, as well as mutation and activation of genes involved in driving cell growth. Using these pathways as examples, we prioritize molecular targets that might be leveraged to promote anti-growth signaling in cancer cells. Interestingly, naturally-occurring phytochemicals found in human diets (either singly or as mixtures) may promote anti-growth signaling, and do so without the potentially adverse effects associated with synthetic chemicals. We review examples of naturally-occurring phytochemicals that may be applied to prevent cancer by antagonizing growth signaling, and propose one phytochemical for each pathway. These are: epigallocatechin-3-gallate (EGCG) for the Rb pathway, luteolin for p53, curcumin for PTEN, porphyrins for Hippo, genistein for GDF15, resveratrol for ARID1A, withaferin A for Notch and diguelin for the IGF1-receptor pathway. The coordination of anti-growth signaling and natural compound studies will provide insight into the future application of these compounds in the clinical setting

Selenium and Vitamin E for Prostate Cancer: Post-SELECT (Selenium and Vitamin E Cancer Prevention Trial) Status

Various formulations of selenium and vitamin E, both essential human dietary components, have been shown to possess a therapeutic and preventive effect against prostate cancer. Fortuitous results of clinical trials also implied a risk-reduction effect of selenium and vitamin E supplements. The Selenium and Vitamin E Cancer Prevention Trial (SELECT), using oral selenium and vitamin E supplementation in disease-free volunteers, was designed to test a prostate cancer chemoprevention hypothesis. SELECT was terminated early because of both safety concerns and negative data for the formulations and doses given. Here, we review and discuss the studies done before and since the inception of SELECT, as well as the parameters of the trial itself. We believe that there is a lack of appropriate in vivo preclinical studies on selenium and vitamin E despite many promising in vitro studies on these agents. It seems that the most effective doses and formulations of these agents for prostate cancer chemoprevention have yet to be tested. Also, improved understanding of selenium and vitamin E biology may facilitate the discovery of these doses and formulations