Map of the HLA class II region in harboring markers rs7775228 and rs10947262.

<p>The frequency of haplotype DRB1*1502 DQA1*0103 DQB1*0601 and its linkage disequilibrium with rs7775228 and rs10947262 in three ethnic groups is shown.</p

Meta-analysis of genetic association between two HLA SNPs and knee OA.

<p>Forest plot of study-specific estimates and random-effects summary effect size and 95% confidence intervals (95%CIs) for the genetic association with knee OA of (<b>A</b>) the major allele (T) at rs7775228 in three published studies and the deCODE case-control study (<b>B</b>) the major allele (C) at rs10947262 in three published studies and seven additional European studies. Square sizes are proportional to the number of cases in each study.</p

Characteristics of cases and controls of unpublished studies included in the analysis.

<p>MAF =  minor allele frequency.</p><p>(1) <b>Minor allele = C, major allele = T.</b></p><p>(2) <b>Minor allele = T, major allele = C.</b></p