Decreasing the load? Is a Multidisciplinary Multistep Medication Review in older people an effective intervention to reduce a patient's Drug Burden Index? Protocol of a randomised controlled trial

INTRODUCTION: Older people often use medications with anticholinergic or sedative side effects which increase the risk of falling and worsen cognitive impairment. The Drug Burden Index (DBI) is a measure of the burden of anticholinergic and sedative medications. Medication reviews are typically done by a pharmacist in collaboration with a general practitioner to optimise the medication use and reduce these adverse drug events. We will evaluate whether a Multidisciplinary Multistep Medication Review (3MR) is an effective intervention to reduce a patient's DBI. METHODS: A randomised controlled trial including 160 patients from 15 community pharmacies will be conducted. Per pharmacy, 1 pharmacist will perform a structured 3MR in close collaboration with the general practitioner, including the objective to reduce the DBI. ANALYSIS: Primary outcome-the difference in proportion of patients having a decrease in DBI≥0.5 in the intervention and control groups at follow-up. Secondary outcomes-anticholinergic and sedative side effects, falls, cognitive function, activities of daily living, quality of life, hospital admission, and mortality. ETHICS AND DISSEMINATION: The burden of patients will be kept at a minimum. The 3MR can be considered as usual care by the pharmacist and general practitioner. Medical specialists will be consulted, if necessary. The intervention is specifically aimed at older community-dwelling patients in an attempt to optimise prescribing, in particular, to reduce medication with anticholinergic and sedative properties. Study results will be published in peer-reviewed journals and will be distributed through information channels targeting professionals. TRIAL REGISTRATION NUMBER: NCT02317666; Pre-results

Student ontwikkelt zich tot zelfbewuste professional

Niesko Pras hield zich aan de Rijksuniversiteit Groningen tot 1 augustus intensief bezig met de optimalisering van het farmacotherapieonderwijs. Hieronder geeft hij zijn visie op heden en toekomst van deze opleiding, samen met Nynke Schuiling-Veninga die een deel van zijn taken heeft overgenomen. “Een volgende stap is verbetering van innovatief praktijkonderzoek.

Student ontwikkelt zich tot zelfbewuste professional

Niesko Pras hield zich aan de Rijksuniversiteit Groningen tot 1 augustus intensief bezig met de optimalisering van het farmacotherapieonderwijs. Hieronder geeft hij zijn visie op heden en toekomst van deze opleiding, samen met Nynke Schuiling-Veninga die een deel van zijn taken heeft overgenomen. “Een volgende stap is verbetering van innovatief praktijkonderzoek.