Meaning making among young adult cohabitors

Despite the increased prevalence of cohabitation, our understanding has been limited by a primarily quantitative focus that neglects to capture the voices of actual cohabitors. Using a symbolic interactionist approach, my study explores the way in which cohabitors construct meaning from the perspective of young adult cohabitors. Based on in-depth interviews with both members of the cohabiting relationship, three different aspects of meaning-making are highlighted. First, I describe two major meanings of cohabitation---cohabitation as relationship and cohabitation as residence---that shape decisions to cohabit and the experience of cohabitation. Second, I explain the meaning of marriage for cohabitors by focusing specifically on gender. Third, I draw attention to respondents\u27 perceptions of the meaning of cohabitation held by their significant others. Each of these aspects contributes to an increased understanding of cohabiting relationships and their place in the dating/marriage world

The Efficacy of Hippotherapy for Physical Rehabilitation: A Systematic Review

Purpose: The purpose of this scholarly project is to examine existing literature pertaining to hippotherapy and conditions impacting physical health through completion of a systematic review. According to the American Hippotherapy Association (AHA, 2017), hippotherapy is defined as “how occupational therapy, physical therapy, and speech-language pathology professionals use evidence-based practice and clinical reasoning in the purposeful manipulation of equine movement to engage sensory, neuromotor, and cognitive systems to achieve functional outcomes” (What is Hippotherapy, para. 1). Hippotherapy was initially cited in occupational therapy practice in the 1980’s, but minimal attention and research have been applied to the topic as time has progressed (Govender, Barlow, & Ballim, 2016). Further review of existing evidence has the potential to increase its acceptance by healthcare practitioners and therapists (Rigby & Grandjean, 2016). Methodology: The literature search was conducted across six databases- PubMed, CINAHL, PsychInfo, SPORTDiscus, SCOPUS, and Cochrane. Articles included in the systematic review must have been quantitative research published in a peer-reviewed journal in the past 15 years. Additionally, articles must have been published in English, refer to a condition impacting one’s physical health, have intervention conducted by an occupational, physical, or speech-language therapy practitioner and be relevant to intervention with a horse. Results/Conclusions: In total, 1955 articles were reviewed from the six databases, and 17 were determined to meet inclusion criteria. Themes identified were client factors, performance skills, and occupational therapy based outcomes. Specific client factors identified in the literature benefitting from hippotherapy included neuromusculoskeletal and movement-related functions and sensory functions such as pain. Some improvements noted in the area of client factors included muscle symmetry, muscle stability, muscle control, muscle tone functions, muscle strength, control of voluntary movement, postural alignment, gait pattern functions, and sensorimotor experiences. Performance skills evident in the literature were identified motor skills, specifically reaching and functional mobility. Although no occupational therapy-specific outcome measures were documented in the literature, outcomes connecting the literature and the Occupational Therapy Practice Framework (OTPF) were identified by the student researchers and included occupational performance, prevention, role competence, and quality of life. Evidence does exist pertaining to the efficacy of hippotherapy related to conditions impacting physical health, but there is a lack of evidence in the fields of occupational therapy, physical therapy, and speech-language therapy. There is a need for conduction of studies with high-level evidence in this area to promote usage of hippotherapy with conditions affecting physical health in the occupational therapy profession. With improvements in client factors and performance skills, occupation-based outcomes are hopeful. Thus, it is recommended future studies explicitly measure occupation-based outcomes related to hippotherapy intervention and physical health conditions

Medial Prefrontal Transcranial Direct Current Stimulation Aimed to Improve Affective and Attentional Modulation of Pain in Chronic Low Back Pain Patients

Chronic low back pain (CLBP) is often without clear underlying pathology. Affective disturbance and dysfunctional pain mechanisms, commonly observed in populations with CLBP, have, therefore, been suggested as potential contributors to CLBP development and maintenance. However, little consensus exists on how these features interact and if they can be targeted using non-invasive brain stimulation. In this pilot trial, 12 participants completed two phases (Active or Sham) of high-definition transcranial direct current stimulation (HD-tDCS) to the medial prefrontal cortex, applied for 20 min on three consecutive days. Clinical pain ratings, questionnaires, and sensitivity to painful cuff pressure were completed at baseline, then 4 trials of conditioned pain modulation (CPM; alone, with distraction using a Flanker task, with positive affect induction, and with negative affect induction using an image slideshow) were performed prior to HD-tDCS on Day 1 and Day 4 (24 h post-HD-tDCS). At baseline, attentional and affective manipulations were effective in inducing the desired state (p p < 0.02) but also showed poor reliability across days. Future work is needed to expand upon these findings and better understand how and if HD-tDCS can be used to enhance attentional and affective effects on pain modulation

Ketones Improves Apolipoprotein E4-Related Memory Deficiency Via Sirtuin 3

Background: Apolipoprotein E4 (ApoE4) is the major genetic risk factor of Alzheimer\u27s disease (AD). ApoE4 carriers have cerebral hypometabolism which is thought as a harbinger of AD. Our previous studies indicated ketones improved mitochondria energy metabolism via sirtuin 3 (Sirt3). However, it is unclear whether ketones upregulate Sirt3 and improve ApoE4-related learning and memory deficits. Results: Ketones improved learning and memory abilities of ApoE4 mice but not ApoE3 mice. Sirt3, synaptic proteins, the NAD+/ NADH ratio, and ATP production were significantly increased in the hippocampus and the cortex from ketone treatment. Methods: Human ApoE3 and ApoE4 transgenic mice (9-month-old) were treated with either ketones or normal saline by daily subcutaneous injections for 3 months (ketones, beta-hydroxybutyrate (BHB): 600 mg/kg/day; acetoacetate (ACA): 150 mg/kg/day). Learning and memory ability of these mice were assessed. Sirt3 protein, synaptic proteins (PSD95, Synaptophysin), the NAD+/ NADH ratio, and ATP levels were measured in the hippocampus and the cortex. Conclusion: Our current studies suggest that ketones improve learning and memory abilities of ApoE4 transgenic mice. Sirt3 may mediate the neuroprotection of ketones by increasing neuronal energy metabolism in ApoE4 transgenic mice. This provides the foundation for Sirt3\u27s potential role in the prevention and treatment of AD

Sirtuin 3 Attenuates Amyloid-Beta Induced Neuronal Hypometabolism

Alzheimer\u27s disease (AD) is manifested by regional cerebral hypometabolism. Sirtuin 3 (Sirt3) is localized in mitochondria and regulates cellular metabolism, but the role of Sirt3 in AD-related hypometabolism remains elusive. We used expression profiling and weighted gene co-expression network analysis (WGCNA) to analyze cortical neurons from a transgenic mouse model of AD (APPSwInd). Based on WGCNA results, we measured NAD+ level, NAD+/ NADH ratio, Sirt3 protein level and its deacetylation activity, and ATP production across both in vivo and in vitro models. To investigate the effect of Sirt3 on amyloid-β (Aβ)-induced mitochondria damage, we knocked down and over-expressed Sirt3 in hippocampal cells. WGCNA revealed Sirt3 as a key player in Aβ-related hypometabolism. In APP mice, the NAD+ level, NAD+/ NADH ratio, Sirt3 protein level and activity, and ATP production were all reduced compared to the control. As a result, learning and memory performance were impaired in 9-month-old APP mice compared to wild type controls. Using hippocampal HT22 cells model, Sirt3 overexpression increased Sirt3 deacetylation activity, rescued mitochondria function, and salvaged ATP production, which were damaged by Aβ. Sirt3 plays an important role in regulating Aβ-induced cerebral hypometabolism. This study suggests a potential direction for AD therapy