Case Control Study of Risk Factors and Ophthalmological Outcomes of Very Low Birth Weight Infants with Type 1 Retinopathy of Prematurity

10.11622/SMEDJ.2019095Singapore Medical Journal618426-43

Associations of physical activity and sedentary behavior during pregnancy with gestational diabetes mellitus among Asian women in Singapore

Background Few studies have investigated physical activity (PA) and sedentary behavior (SB) in relation to fasting (FG) and 2-h postprandial plasma glucose (2hPG) levels and gestational diabetes mellitus (GDM); we investigated these associations among Asian pregnant women. Methods As part of the Growing Up in Singapore Towards healthy Outcomes cohort study, PA and SB (sitting and television times) were assessed by interviewer-administered questionnaire. During 75 g oral glucose tolerance tests at 26–28 weeks’ gestation we measured FG, 2hPG levels and GDM (FG ≥ 7.0 mmol/L and/or 2hPG ≥ 7.8 mmol/L). Associations were analysed by multiple linear and logistic regression. Results Among the 1083 women studied, 18.6% had GDM. SB was not associated with FG, 2hPG and GDM. Higher categories of PA were associated with lower 2hPG and a lower likelihood of GDM (p-trend <0.05), but not with FG levels. Compared to insufficiently active women, highly active women had lower 2hPG levels [β (95% CI): -0.32 (−0.59, −0.05), p = 0.020) and were less likely to have GDM [OR: 0.56 (0.32–0.98), p = 0.040]. Stratified analysis revealed no associations among under/normal-weight women, but significant associations among overweight/obese women; in those with BMI ≥23 kg/m2, sufficiently active and highly active women were less likely to have GDM [OR: 0.52, (0.29–0.93), p = 0.028, and OR: 0.34, (0.15–0.77), p = 0.010, respectively]. Conclusion Higher PA was associated with lower 2hPG levels and a lower prevalence of GDM, particularly in overweight/obese women. Further studies are warranted to confirm these findings, and to examine the effectiveness of PA promotion strategies for the prevention of gestational hyperglycemia. Keywords: Physical activity, Sedentary behavior, Gestational diabetes mellitus, Maternal glucose levels, Pregnanc

Associations of physical activity and sedentary behavior during pregnancy with gestational diabetes mellitus among Asian women in Singapore

10.1186/s12884-017-1537-8BMC Pregnancy and Childbirth171Article number 364BPCMBGUSTO (Growing up towards Healthy Outcomes

Cohort profile: Growing up in Singapore towards healthy outcomes (GUSTO) birth cohort study

10.1093/ije/dyt125International Journal of Epidemiology4351401 - 1409IJEPBGUSTO (Growing up towards Healthy Outcomes

Gestational age and neonatal brain microstructure in term born infants: A birth cohort study

10.1371/journal.pone.0115229PLoS ONE912e11522