Fertility outcomes following myomectomy in infertile patients at our centre: a retrospective analysis

Background: Fibroids have been known to cause infertility due to multiple factors. However, the role of myomectomy in patients with intramural and subserosal fibroids has been a topic of debate. This study evaluates outcomes following myomectomy in patients seeking treatment for infertility at study centre.Methods: This was hospital based retrospective study which evaluated 92 infertile patients who took treatment for infertility.Results: A total 41.3% patients conceived within one year of myomectomy. Pregnancy rates were better in patients with intramural combined with submucous fibroids, age between 30 and 35 years, size of largest fibroid between 3 and 6 cm and when number of fibroids were between 3 and 6 and conception was maximum after ovulation induction.Conclusions: Pregnancy rates after myomectomy are better in young patients with large fibroids. Active management for infertility needs to be done after myomectomy

A Review on Resemblance of User Profiles in Social Networks using Similarity Measures

Online Social Networking is increasing at a fast rate. There are lots of profiles of the users and there is too much resemblance between the user profiles which can help recruiter’s to select the best candidates for the Job Profile. Now, each similarity measure has its own applicability and best suited to a particular type of attribute values and if these measures are collectively combined then it can help us to find the best resemblance among the user profile ,the result of which matches to the actual result. In this paper, the discussion of the past studies is done and how our research is proposing a framework for finding the resemblance is being discussed.

To study the role of visual inspection of cervix with acetic acid (VIA) in cervical cancer screening

Background: Objectives of current study were to evaluate visual inspection of cervix with acetic acid in picking up abnormal cervix and to correlate the findings of VIA with Pap smear, colposcopy and cervical biopsy.Methods: Study was conducted on 300 sexually active women attending the gynaecological OPD at Dayanand medical college and hospital, Ludhiana. All patients underwent VIA & Pap smear screening and if either of the two was abnormal, colposcopy was done & colposcopic guided cervical biopsy was taken if indicated. Total 105 colposcopies were done. Cervical biopsy was taken in 87 cases and the results were compared and statistically analysed.Results: The sensitivity of VIA was 86% and specificity 40.50%. No case was missed by VIA when cut off was taken as moderate dysplasia or higher lesions on biopsy.Conclusions: VIA is a sensitive, practical and a low cost affair in cervical cancer screening

Cervical ectopic pregnancy: ultrasound diagnosis and conservative management

An ectopic pregnancy is one in which the fertilized ovum is implanted and develops outside the normal endometrial cavity. Cervical ectopic pregnancy is a rare form of ectopic pregnancy and can be defined as implantation of blastocyst in the endocervix, below the internal os; representing less than 1 % of all ectopic pregnancies. Ultrasound diagnosis of this abnormal pregnancy was first described by Raskin (1978); thus early diagnosis in either weakly or non-symptomatic women in the first trimester is done; allowing conservative management. A 35 year old female, gravida 4 with living 1 issue and 2 abortions presented with a history of continuous bleeding per vaginum for last 1.5 months. Outside ultrasound depicted single live fetus of 7 weeks in cervical canal. She had a history of undergoing medical termination of pregnancy by surgical procedure of dilatation and evacuation at private hospital for completion of abortion. There was a history of excessive bleeding post procedure and 2 units of blood transfusion; referred in anaemic state to our institute with pack in situ. Pack was removed after 24 hours and managed conservatively. On general examination tachycardia present, BP was normal and patient was haemodynamically stable. On palpation abdomen was soft, non-tender and no organomegaly noticed. Urine pregnancy test was positive, serum βHCG levels were raised, USG depicted heterogeneous collection in cervix. Injection methotrenate (1mg/Kg body wt.) given. βhCG repeated after 7 days; levels decreased significantly. Patient was improved symptomatically and bleeding stopped. Cervical pregnancy is a rare condition, if not diagnosed and treated early during the course of pregnancy can have hazardous complications. Thus early diagnosis and management is necessary for preserving patient’s fertility without significant complications

A Survey on Intrusion Detection in Wireless Sensor Networks

ABSTRACT In recent years, the applications based on the Wireless Sensor Networks are growing very fast. The application areas include agriculture, healthcare, military, hospitality management, mobiles and many others. So these networks are very important for us and the security of the network from the various attacks is also a more important issue in WSN application now days. Stopping these attacks or enhancing the security of the WSN system various intrusion detection policies are developed till date to detect the node/s that is/are not working normally. Out of various detection techniques three major categories explored in this paper are Anomaly detection, Misuse detection and Specificationbased detection. Here in this review paper various attacks on Wireless Sensor Networks and existing Intrusion detection techniques are discussed to detect the compromised node/s. The paper also provides a brief discussion about the characteristics of the Wireless Sensor Networks and the classification of attacks

A case report on nasolabial cyst

The nasolabial cyst (NLC) is an uncommon clinical entity and is generally unilateral. It is benign in nature and is embryonic in origin and only one case with malignancy has been reported. It is located in the nasolabial folds. Most of time it is an asymptomatic deformity of face and rarely can result in nasal obstruction if it is bilateral. Its diagnosis is clinical and treatment is surgical excision. A 16 years brown female patient presented with bulging in left nasolabial region. She was treated with surgery...........................................................Cite this article as:Goyal S, Sharma J, Sharma N. A case report on nasolabial cyst. Int J Cancer Ther Oncol 2014; 2(3):020311. DOI: 10.14319/ijcto.0203.1

Ultrastructural Characterization of Serially Passaged Amastigote Like Forms of Leishmania (Leishmania) Donovani

The present study was done to establish an in vitro axenic culture of amastigote like forms of Leishmania (Leishmania) donovani (Dd-8 strain), the causative agent of Indian kala-azar. Transformation of promastigotes to amastigote like forms was induced by temperature shift from 26±1℃ to 34±1℃ at pH 7.0 in NNN medium. These forms were dividing as evidenced by flow cytometry. Scanning and transmission electron microscopic studies revealed a remarkable ultrastructural similarity of these in vitro cultured amastigotes with intracellular amastigotes. These forms have been successfully maintained for a period of more than one year, during which they have remained infective. On subjecting these forms to temperature of 26±1℃, they reverted back to the promastigote forms. Thus a simple NNN medium, free from foetal calf serum has been developed to generate large amounts of amastigote like forms which can be used for further biochemical, immunological and chemotherapeutic studies

An Open Label, Randomized, Multicenter Study of Elafibranor in Children With Nonalcoholic Steatohepatitis

ObjectivesNonalcoholic fatty liver disease is the most common chronic liver disease in children. Elafibranor, a dual peroxisome proliferator-activated receptor α/δ agonist, has been proposed as a treatment for nonalcoholic steatohepatitis (NASH). The aims were to (1) describe pharmacokinetics (PK), safety, and tolerability of oral elafibranor at 2 doses (80 and 120 mg) in children 8-17 years and (2) assess changes in aminotransferases.MethodsChildren with NASH were randomized to open-label elafibranor 80 mg or 120 mg daily for 12 weeks. The intent-to-treat analysis included all participants who received at least 1 dose. Standard descriptive statistics and PK analyses were performed.ResultsTen males [mean 15.1 years, standard deviation (SD) 2.2] with NASH were randomized to 80 mg (n = 5) or 120 mg (n = 5). Baseline mean alanine aminotransferase (ALT) was 82 U/L (SD 13) and 87 U/L (SD 20) for 80 mg and 120 mg groups, respectively. Elafibranor was rapidly absorbed and well tolerated. Elafibranor plasma exposure increased between the 80 mg and 120 mg dose with a 1.9- and 1.3-fold increase in median Cmax and AUC 0-24 , respectively. End of treatment mean ALT was 52 U/L (SD 20) for the 120 mg group, with a relative mean ALT change from baseline of -37.4% (SD 23.8%) at 12 weeks.ConclusionsOnce daily dosing of elafibranor was well tolerated in children with NASH. There was a 37.4% relative reduction from mean baseline ALT in the 120 mg group. Decreasing ALT may be associated with improvement in liver histology, thus could be considered a surrogate for histology in early phase trials. These results may support further exploration of elafibranor in children with NASH