In vitro release of lectins by Phallusia mamillata hemocytes

α-Lactose specific lectins are released from Phallusia mamillata hemocytes during short-term cultures. The molecular weight of the subunits, the immunological cross-reaction and the sugar specificity suggest that the released lectins are similar to those isolated from the sonicated hemocytes. Because lectin release appears to take place independently of active protein synthesis, the possibility exists that lectins are pre-formed, stored in hemocytes and released when in vitro conditions stimulate the cells. © 1991

Iginio Tansini revisited

The origin of the muscolocutaneous latissimus dorsi flap dates back to 1906 when Igino Tansini, an Italian surgeon, described a procedure to reconstruct the mastectomy defect. After a detailed study of Tansini's original description and drawings, new insights about the pedicle of its compound flap have been found, showing that it has the same pedicle of the scapular flap. In the end, Tansini's flap should be more correctly considered as a compound musculocutaneous scapular flap

An improved method of supercharged transposed latissimus dorsi flap with the skin paddle for the management of a complicated lumbosacral defect

OBJECTIVE: Treatment of nonhealing wounds of lower back often poses a powerful challenge. We present one of the first report of treatment of a lumbosacral defect with a supercharged latissimus dorsi flap with the skin paddle. CASE REPORT: We report a case of a 59 yearold man with myeloma of the sacral spine who underwent radiotherapy and chemotherapy and subsequently, laminectomies and placement of hardware for ongoing paresis and spine instability. Then, he developed an open wound and osteomyelitis of the spine with culture positive tuberculous granulomas. After multiple surgical debridement, he presented to our service and was treated with a single stage debridement followed by the performance of a latissimus dorsi musculocutaneous flap based on paraspinal perforators and supercharged. RESULTS: This solution, allowed for augmentation of blood flow to the muscle with the inferior gluteal artery, provided coverage of the defect resistant to the pressure, and simplified post-operative management of the patient. CONCLUSIONS: Alternative treatment options, including free tissue transfer, posed difficulties in finding suitable recipient vessels near the defect, in inserting the flap so as to restore its original length without compromising blood flow, and in postoperative care of the patient. Treatment of a lumbosacral defect with a supercharged latissimus dorsi flap with the skin paddle may represent a milestone procedure for complicated lower spine wounds

Constraints on Modified Gravity from Sunyaev-Zeldovich Cluster Surveys

We investigate the constraining power of current and future Sunyaev-Zeldovich cluster surveys on the f(R) gravity model. We use a Fisher matrix approach, adopt self-calibration for the mass- observable scaling relation, and evaluate constraints for the SPT, Planck, SPTPol and ACTPol surveys. The modified gravity effects on the mass function, halo bias, matter power spectrum, and mass-observable relation are taken into account. We show that, relying on number counts only, the Planck cluster catalog is expected to reduce current upper limits by about a factor of four, to {\sigma}fR0 = 3 {\times} 10-5 (68% confidence level). Adding the cluster power spectrum further improves the constraints to {\sigma}fR0 = 10-5 for SPT and Planck, and {\sigma}fR0 = 3 {\times} 10-6 for SPTPol, pushing cluster constraints significantly beyond the limit where number counts have no constraining power due to the chameleon screening mechanism. Further, the combination of both observables breaks degeneracies, especially with the expansion history (effective dark energy density and equation of state). The constraints are only mildly worsened by the use of self-calibration but depend strongly on the mass threshold of the cluster samples.Comment: 16 pages, 9 figure

Forensic psychiatric evaluations of defendants: Italy and the Netherlands compared

Background: Forensic psychiatric practices and provisions vary considerably across jurisdictions. The diversity provides the possibility to compare forensic psychiatric practices, as we will do in this paper regarding Italy and the Netherlands. Aim: We aim to perform a theoretical analysis of legislations dealing with the forensic psychiatric evaluation of defendants, including legal insanity and the management of mentally ill offenders deemed insane. This research is carried out not only to identify similarities and differences regarding the assessment of mentally ill offenders in Italy and the Netherlands, but, in addition, to identify strengths and weaknesses of the legislation and procedures used for the evaluation of the mentally ill offenders in the two countries. Results: Italy and the Netherlands share some basic characteristics of their criminal law systems. Yet, forensic psychiatric practices differ significantly, even if we consider only evaluations of defendants. A strong point of Italy concerns its test for legal insanity which defines the legal norm and enables a straightforward communication between the experts and the judges on this crucial matter. A strong point of the Netherlands concerns more standardized practices including guidelines and the use of risk assessment tools, which enable better comparisons and scientific research in this area. Conclusions: We argue that there appears to be room for improvement on both sides with regards to the evaluation of mentally ill offenders. More generally, a transnational approach to these issues, as applied in this paper, could help to advance forensic psychiatric services in different legal systems

SGR 0418+5729: a low-magnetic-field magnetar

Soft gamma-ray repeaters and anomalous X-ray pulsars are a small (but growing) group of X-ray sources characterized by the emission of short bursts and by a large variability in their persistent flux. They are believed to be magnetars, i.e. neutron stars powered by extreme magnetic fields 1E14-1E15 G). We found evidence for a magnetar with a low magnetic field, SGR 0418+5729, recently detected after it emitted bursts similar to those of soft gamma-ray repeaters. New X-ray observations show that its dipolar magnetic field cannot be greater than 8E12 G, well in the range of ordinary radio pulsars, implying that a high surface dipolar magnetic field is not necessarily required for magnetar-like activity. The magnetar population may thus include objects with a wider range of magnetic-field strengths, ages and evolutionary stages than observed so far.Comment: 4 pages, 2 figures; to appear in the Proceedings of the Pulsar Conference 2010, Chia, Sardinia (Italy), 10-15 October 201

Satellite-derived, melt-season surface temperature of the Greenland Ice Sheet (2000–2005) and its relationship to mass balance

Author Posting. © American Geophysical Union, 2006. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geophysical Research Letters 33 (2006): L11501, doi:10.1029/2006GL026444.Mean, clear-sky surface temperature of the Greenland Ice Sheet was measured for each melt season from 2000 to 2005 using Moderate-Resolution Imaging Spectroradiometer (MODIS)–derived land-surface temperature (LST) data-product maps. During the period of most-active melt, the mean, clear-sky surface temperature of the ice sheet was highest in 2002 (−8.29 ± 5.29°C) and 2005 (−8.29 ± 5.43°C), compared to a 6-year mean of −9.04 ± 5.59°C, in agreement with recent work by other investigators showing unusually extensive melt in 2002 and 2005. Surface-temperature variability shows a correspondence with the dry-snow facies of the ice sheet; a reduction in area of the dry-snow facies would indicate a more-negative mass balance. Surface-temperature variability generally increased during the study period and is most pronounced in the 2005 melt season; this is consistent with surface instability caused by air-temperature fluctuations.Support for this work was provided by NASA’s Earth Observing System and Cryospheric Sciences Programs

On the wave-cancelling nature of boundary layer flow control

International audienceThis work deals with the feedforward active control of Tollmien–Schlichting instability waves over incompressible 2D and 3D boundary layers. Through an extensive numerical study, two strategies are evaluated; the optimal linear–quadratic–Gaussian (LQG) controller, designed using the Eigensystem realization algorithm, is compared to a wave-cancellation scheme, which is obtained using the direct inversion of frequency-domain transfer functions of the system. For the evaluated cases, it is shown that LQG leads to a similar control law and presents a comparable performance to the simpler, wave-cancellation scheme, indicating that the former acts via a destructive interference of the incoming wavepacket downstream of actuation. The results allow further insight into the physics behind flow control of convectively unstable flows permitting, for instance, the optimization of the transverse position for actuation. Using concepts of linear stability theory and the derived transfer function, a more efficient actuation for flow control is chosen, leading to similar attenuation of Tollmien–Schlichting waves with only about 10% of the actuation power in the baseline case