Primary, Bilateral and Diffuse Renal Non-Hodgkin's Lymphoma in a Young Woman Suffering from Turner Syndrome

Primary renal lymphoma (PRL) is a rare form of non-Hodgkin's lymphoma (NHL) restricted to and primarily involving one or both kidneys, with no lymph node extension. It accounts for <1% of extranodal lymphomas, and descriptions in the literature are limited. Here, we describe an unprecedented case of bilateral PRL in a 44-year-old woman with Turner syndrome and discuss both diagnostic and therapeutic issues in the light of the available literature in the field. A personalized approach to this rare disease is necessary

Modeling and simulation in tribology across scales: An overview

This review summarizes recent advances in the area of tribology based on the outcome of a Lorentz Center workshop surveying various physical, chemical and mechanical phenomena across scales. Among the main themes discussed were those of rough surface representations, the breakdown of continuum theories at the nano- and micro-scales, as well as multiscale and multiphysics aspects for analytical and computational models relevant to applications spanning a variety of sectors, from automotive to biotribology and nanotechnology. Significant effort is still required to account for complementary nonlinear effects of plasticity, adhesion, friction, wear, lubrication and surface chemistry in tribological models. For each topic, we propose some research directions

A generalized Paris' law for fatigue crack growth

An extension of the celebrated Paris law for crack propagation is given to take into account some of the deviations from the power-law regime in a simple manner using the Wohler SN curve of the material, suggesting a more general "unified law". In particular, using recent proposals by the first author, the stress intensity factor K(a) is replaced with a suitable mean over a material/structural parameter length scale Delta a, the "fracture quantum". In practice, for a Griffith crack, this is seen to correspond to increasing the effective crack length of Delta a, similarly to the Dugdale strip-yield models. However, instead of including explicitly information on cyclic plastic yield, short-crack behavior, crack closure, and all other detailed information needed to eventually explain the SN curve of the material, we include directly the SN curve constants as material property. The idea comes as a natural extension of the recent successful proposals by the first author to the static failure and to the infinite life envelopes. Here, we suggest a dependence of this fracture "quantum" on the applied stress range level such that the correct convergence towards the Wohler-like regime is obtained. Hence, the final law includes both Wohler's and Paris' material constants, and can be seen as either a generalized Wohler's SN curve law in the presence of a crack or a generalized Paris' law for cracks of any siz

Thrombotic events during oral anticoagulant treatment: results of the inception cohort prospective collaborative ISCOAT study

The paper reports on rate and type of thrombotic events occurring during the observational, prospective, inception-cohort, multicenter ISCOAT study. 2,745 unselected, daily practice patients, consecutively referring to 34 Italian anticoagulation clinics to monitor the oral anticoagulant treatment, were included in the study from beginning of their first anticoagulant course. During a total follow-up of 2,011 patient-years of treatment 70 thrombotic events (3.5 per 100 patient years) were recorded in 67 patients: 20 fatal (1%), 39 major (1.9%) and 11 minor (0.6%). 34/70 events occurred within the first 90 days of treatment (relative risk - at multivariate analysis - of 90 = 20.6, C.I. 12.7-33.5; p or =70 y (1.62, C.I. 1.0-2.61; p or =2 = 1.88, C.I. 1.16-3.07; p 70 years and in those with cerebrovascular/peripheral arterial disease