Thrombotic events during oral anticoagulant treatment: results of the inception cohort prospective collaborative ISCOAT study

The paper reports on rate and type of thrombotic events occurring during the observational, prospective, inception-cohort, multicenter ISCOAT study. 2,745 unselected, daily practice patients, consecutively referring to 34 Italian anticoagulation clinics to monitor the oral anticoagulant treatment, were included in the study from beginning of their first anticoagulant course. During a total follow-up of 2,011 patient-years of treatment 70 thrombotic events (3.5 per 100 patient years) were recorded in 67 patients: 20 fatal (1%), 39 major (1.9%) and 11 minor (0.6%). 34/70 events occurred within the first 90 days of treatment (relative risk - at multivariate analysis - of 90 = 20.6, C.I. 12.7-33.5; p or =70 y (1.62, C.I. 1.0-2.61; p or =2 = 1.88, C.I. 1.16-3.07; p 70 years and in those with cerebrovascular/peripheral arterial disease