10 research outputs found
Kekacauan dan kerusuhan : tiga tulisan tentang Pan-Islamisme di Hindia-Belanda timur pada akhir abad kesembilan belas dan awal abad kedua puluh
Shi`ism in South East Asia: `Alid Piety and Sectarian Constructions. Edited by Chiara Formichi and Michael Feener. Oxford: Oxford University Press, 2015. 416 pp. ISBN: 9780190264017 (cloth, also available as e-book).
The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics
The emerging antibiotics-resistance problem has underlined the urgent need for novel antimicrobial agents. Lantibiotics (lanthionine-containing antibiotics) are promising candidates to alleviate this problem. Nisin, a member of this family, has a unique pore-forming activity against bacteria. It binds to lipid II, the essential precursor of cell wall synthesis. As a result, the membrane permeabilization activity of nisin is increased by three orders of magnitude. Here we report the solution structure of the complex of nisin and lipid H. The structure shows a novel lipid II-binding motif in which the pyrophosphate moiety of lipid II is primarily coordinated by the N-terminal backbone amides of nisin via intermolecular hydrogen bonds. This cage structure provides a rationale for the conservation of the lanthionine rings among several lipid II-binding lantibiotics. The structure of the pyrophosphate cage offers a template for structure-based design of novel antibiotics