Contribution to the study on chemical constituents of Hedyotis auricularia L., (Rubiaceae)

From the whole plant of Hedyotis auricularia L., a new glycoside, 1’-deoxy-6’-O-(1-hydroxymethyl-2-hydroxy-1-methoxy)ethylglucopyranoside (1) was isolated along with 1’-O-ethyl-β-D-galactopyranoside (2), 2-formyl-5-hydroxymethylfuran (3), stigmasta-5,22-diene-3-O-β-D-glucopyranoside (4), ursolic acid (5) and oleanolic acid (6). Among them (1), (2), (3), (4)were the first time known to be present in this plant

Chemical examination of Hydrocotyle bonariensis L. (Apiaceae)

Hydrocotyle bonariensis, growing in the Mekong-delta, is used as vegetable and has not yet been chemically studied. From the aerial parts of H. bonariensis, three compounds had been isolated: a triterpene squalene (1) and a mixture of two lignans: hinokinin (2) and α-[3,4-methylendioxy phenylmethylidene]-β-[3,4-methylendioxyphenylmethyl]-γ-butyrolactone (3). The fresh plant was divided into stem-leaf and flower and each part was distilled with steam to afford essential oils. The major components of stem-leaf are: (Z)-3-hexen-1-ol, trans-caryophyllene, α-farnesene, copaene while the major components of flower are: α-pinene, 2-β-pinene, β-myrcene, limonene, α-caryophyllene, epibicyclosesquiphellandrene. The essential oil of the stem-leaf showed cytotoxic activities in vitro on RD and Hep-G2 cancer cells with the IC50 values of 16.1 and 19.9µg/ml, respectively. The study on the plant is being continued

Some di- and triterpenes of Wedelia urticaefolia (Bl.) (Asteraceae)

Wedelia urticaefolia Bl. DC. (Vietnamese name Sơn cúc nhám) has not yet been chemically studied. From leaves of this plant, four compounds were isolated: phytol (1), 3β-O-acetyl-b-amyrin (2), 3-O-tetradecanoylurs-12-ene-16β-ol (3), ent-kaur-16-ene-19-oic acid (4) and from the flowers, three compounds were isolated: b-amyrin (5), stigmasterol (6) and 3-O-tetradecanoylurs-12-ene-16β-ol (3). Their chemical structures were established by spectroscopic analysis

Anthraquinones from Hedyotis pinifolia

Hedyotis pinifolia Wall ex G.Don (Vietnamsese name An điền lá thông), family of Rubiaceae, has not yet been chemically studied. From the aerial parts of H. pinifolia, four anthraquinones had been isolated: 1,6-dihydroxy-7-methoxy-2-methylanthraquinone (1), 1,6-dihydroxy-2-methylanthraquinone (2), 3,6-dihydroxy-2-methylanthraquinon (3) and 1,3,6-trihydroxy-2-methylanthraquinone (4). Their chemical structures were established by spectroscopic analysis.

Some triterpenoids and steroids from Bruguiera cylindrica leaves collected from Can Gio mangrove forest

Bruguiera cylindrica (Rhizophoracea), distributed in the Southeast Asia, has been used as a traditional medicine in the treatment of diarrhea and healing of wounds. Some triterpenoids and steroids were isolated from the dried leaves of Bruguiera cylindrica, collected at Can Gio mangrove forest, Ho Chi Minh City, including lupeol (1), 3β-hydroxyoleana-9(11),12-diene (2), a mixture of stigmasterol (3a) and b-sitosterol (3b), cholesta-4-ene-3-one (4) and 3β-hydroxycholesta-5-ene-7-one (5). Their chemical structures were elucidated by spectroscopic analysis as well as comparing their data with the ones in the literature. Although these compounds were known in other plants this is the first time they are reported in this species. Keywords. Bruguiera cylindrica, triterpenoids, steroids