STELLAR ORIGINS OF EXTREMELY C-13- AND N-15-ENRICHED PRESOLAR SIC GRAINS: NOVAE OR SUPERNOVAE?

Extreme excesses of 13C (12C/13C < 10) and 15N (14N/15N < 20) in rare presolar SiC grains have been considered diagnostic of an origin in classical novae, though an origin in core collapse supernovae (CCSNe) has also been proposed. We report C, N, and Si isotope data for 14 submicron- to micron-sized 13C- and 15N-enriched presolar SiC grains (12C/13C < 16 and 14N/15N < ~100) from Murchison, and their correlated Mg–Al, S, and Ca–Ti isotope data when available. These grains are enriched in 13C and 15N, but with quite diverse Si isotopic signatures. Four grains with 29,30Si excesses similar to those of type C SiC grains likely came from CCSNe, which experienced explosive H burning occurred during explosions. The independent coexistence of proton- and neutron-capture isotopic signatures in these grains strongly supports heterogeneous H ingestion into the He shell in pre-supernovae. Two of the seven putative nova grains with 30Si excesses and 29Si depletions show lower-than-solar 34S/32S ratios that cannot be explained by classical nova nucleosynthetic models. We discuss these signatures within the CCSN scenario. For the remaining five putative nova grains, both nova and supernova origins are viable because explosive H burning in the two stellar sites could result in quite similar proton-capture isotopic signatures. Three of the grains are sub-type AB grains that are also 13C enriched, but have a range of higher 14N/15N. We found that 15N-enriched AB grains (~50 < 14N/15N < ~100) have distinctive isotopic signatures compared to putative nova grains, such as higher 14N/15N, lower 26Al/27Al, and lack of 30Si excess, indicating weaker proton-capture nucleosynthetic environments

Ctt1 catalase activity potentiates antifungal azoles in the emerging opportunistic pathogen Saccharomyces cerevisiae

Fungi respond to antifungal drugs by increasing their antioxidant stress response. How this impacts antifungal efficacy remains controversial and not well understood. Here we examine the role of catalase activity in the resistance of Saccharomyces cerevisiae to the common antifungals, fluconazole and miconazole, for which we report minimum inhibitory concentrations (MICs) of 104 and 19 μM, respectively. At sub-MIC concentrations, fluconazole and miconazole stimulate catalase activity 2-3-fold but, unexpectedly, deletion of cytosolic catalase (ctt1) makes cells more resistant to these azoles and to clotrimazole, itraconazole and posaconazole. On the other hand, upregulating Ctt1 activity by preconditioning with 0.2 mM H2O2 potentiates miconazole 32-fold and fluconazole 4-fold. Since H2O2 preconditioning does not alter the resistance of ctt1Δ cells, which possess negligible catalase activity, we link azole potentiation with Ctt1 upregulation. In contrast, sod2Δ cells deleted for mitochondrial superoxide dismutase are 4–8-fold more azole sensitive than wild-type cells, revealing that Sod2 activity protects cells against azole toxicity. In fact, the ctt1Δ mutant has double the Sod2 activity of wild-type cells so ctt1 deletion increases azole resistance in part by Sod2 upregulation. Notably, deletion of peroxisomal/mitochondrial cta1 or cytosolic sod1 does not alter fluconazole or miconazole potency

Stellar Origins of Extremely 13C^{\text{13}}C- and 15N^{15}N-enriched Presolar SiC Grains: Novae or Supernovae?

Extreme excesses of $^{13}C$ ($^{12}C$/$^{13}C$<10) and $^{15}N$ ($^{14}N$/$^{15}N$<20) in rare presolar SiC grains have been considered diagnostic of an origin in classical novae, though an origin in core collapse supernovae (CCSNe) has also been proposed. We report C, N, and Si isotope data for 14 submicron- to micron-sized $^{13}C$- and $^{15}N$-enriched presolar SiC grains ($^{12}C$/$^{13}C$<16 and $^{14}N$/$^{15}N$<~100) from Murchison, and their correlated Mg-Al, S, and Ca-Ti isotope data when available. These grains are enriched in $^{13}C$ and $^{15}N$, but with quite diverse Si isotopic signatures. Four grains with $^{29,30}Si$ excesses similar to those of type C SiC grains likely came from CCSNe, which experienced explosive H burning occurred during explosions. The independent coexistence of proton- and neutron-capture isotopic signatures in these grains strongly supports heterogeneous H ingestion into the He shell in pre-supernovae. Two of the seven putative nova grains with $^{30}Si$ excesses and $^{29}Si$ depletions show lower-than-solar $^{34}S$/$^{32}S$ ratios that cannot be explained by classical nova nucleosynthetic models. We discuss these signatures within the CCSN scenario. For the remaining five putative nova grains, both nova and supernova origins are viable because explosive H burning in the two stellar sites could result in quite similar proton-capture isotopic signatures. Three of the grains are sub-type AB grains that are also $^{13}C$ enriched, but have a range of higher $^{14}N$/$^{15}N$. We found that $^{15}N$-enriched AB grains (~50<$^{14}N$/$^{15}N$<~100) have distinctive isotopic signatures compared to putative nova grains, such as higher $^{14}N$/$^{15}N$, lower $^{26}Al$/$^{27}Al$, and lack of $^{30}Si$ excess, indicating weaker proton-capture nucleosynthetic environments.Comment: fix typo in one of the authors' name

African American Extended Family and Church‐Based Social Network Typologies

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/136022/1/fare12218.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/136022/2/fare12218_am.pd

Health, disability, psychological well-being, and depressive symptoms among older African American women

This study examines the demographic correlates of psychological well-being (i.e., happiness and life satisfaction) and mental health (i.e., depressive symptoms and serious psychological distress) among older African American women. Addition- ally, the relationships between self-rated physical and oral health and disability and psychological well-being and mental health are explored. Analyses are based on a nationally representative sample of older African American women from the National Survey of American Life. Results indicate that psychological well-being (i.e., life satisfaction and happiness) and mental health (i.e., depressive symptoms and serious psychological distress) are associated with specific demographic factors. In addition, self-rated health and limited mobility due to disability exerted significant influences on psychological well-being, depressive symptoms, and psychological distress. Findings are discussed in relation to prior research on demographic and health factors and their unique associations with well-being and mental status among older African American women.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107409/1/Health, Disability, Psychological Well-Being, and Depressive Symptoms among Older African American Women.pdfDescription of Health, Disability, Psychological Well-Being, and Depressive Symptoms among Older African American Women.pdf : Main articl

Church-based social support and suicidality among African Americans and Black Caribbeans

This study explores the relationship between church-based informal social support and lifetime prevalence of suicide ideation and attempts within a representative national sample of African American and Black Caribbean adults. Characteristics of church-based social support networks, as well as emotional support and negative interaction with church members were examined in relation to lifetime suicide ideation and attempts. This study used data from the National Survey of American Life (2001–2003). Frequency of interaction with church members was positively associa- ted with suicide attempts, while subjective closeness to church members was negatively associated with suicide ideation. Emotional support, service attendance, and negative interaction with church members were unrelated to both suicide ideation and attempts. Findings are discussed in relation to research on church-based support networks, dif- ferent models linking church support and suicidality, and the mechanisms by which church-based networks deter suicide ideation and attempts.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107407/1/Church based social support Chatters et al 2011.pdfDescription of Church based social support Chatters et al 2011.pdf : Main articl

Subjective well-being of older African Americans with DSM IV psychiatric disorders

This study examined demographic and mental health correlates of subjective well-being (i.e., life satisfaction, happiness) using a national sample of older African Americans with psychiatric disorders. We used a subsample of 185 African Americans, 55 and older with at least one of thirteen lifetime psychiatric disorders from The National Survey of American Life: Coping with Stress in the Twenty-first Century. The findings indicated that among this population of older adults who had a lifetime psychiatric dis- order, having a lifetime suicidal ideation was associated with life satisfaction but not happiness. Further, having a 12-month anxiety disorder or a lifetime suicidal ideation was not associated with happiness. Having a 12-month mood disorder, however, was negatively associated with an individual’s level of happiness, as well as their life satisfaction. Additionally, there were two significant interactions. Among men, employment was pos- itively associated with life satisfaction, and marriage was associated with higher levels of happiness among men but not women. The overall pattern of findings reflects both simi- larities and departures from prior research confirming that well-being evaluations are associated with multiple factors.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107412/1/art%3A10.1007%2Fs10902-013-9470-7(1).pdfDescription of art%3A10.1007%2Fs10902-013-9470-7(1).pdf : Main articl

The relationship between obsessive-compulsive disorder and religious faith: Clinical characteristics and implications for treatment

This paper explores the relationship between religion and obsessive–compulsive dis- order (OCD), with particular interest in religion’s possible influence in the development of OCD and its impact on treatment outcome. The paper begins with a review of theoretical and research literatures concerning religious involvement, research evidence linking religious involvement and physical and mental health, and theoretical linkages supporting both positive and negative religious effects on health. Following this, we provide a general overview and description of OCD and information concerning the prevalence and incidence of religiously based OCD. Next, extant research linking religion and OCD is presented. Information relevant to the clinical treatment of OCD with religious content is discussed. Finally, practice implications for clinicians and clergy are provided.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107413/1/2011-11166-001.pdfDescription of 2011-11166-001.pdf : Main articl

Comorbid mood and anxiety disorders, suicidal behavior, and substance abuse among Black Caribbeans in the U.S.A.

The purpose of this study was to examine nativity and country of origin differences in comorbid mood (major depressive disorder, dysthymia, and bipolar I and II disorders) and anxiety (post-traumatic stress disorder, panic disorder, agora- phobia, social phobia, generalized anxiety disorder, and obsessive compulsive disor- der) disorders among Black Caribbeans in the U.S.A. The paper also examines the relationship between comorbid psychiatric disorders and substance abuse disorders and suicidal behavior. Data are taken from the Black Caribbean sub-sample (N0 1,621) of the National Survey of American Life. Multinomial logistic regression and logistic regression analysis are used and odd ratios, relative risk ratios, and 95 % confidence intervals are presented. Seven percent (7.19 %) of respondents had comorbid mood and anxiety disorders, 8.66 % had a mood disorder only, and 11.46 % had an anxiety disorder only. First-generation Black Caribbeans were less likely than US-born respondents to have a lifetime mood or anxiety disorder and also less likely to have a lifetime substance disorder or a lifetime suicidal attempt. Black Caribbean men were more likely than Black Caribbean women to: (1) have anxiety disorders only versus neither mood or anxiety disorders, (2) to have a substance disorder, and (3) to have had a suicidal attempt. Lastly, Black Caribbeans with both mood and anxiety disorders have significantly higher rates of mental health services utilization. These and other findings are discussed in detail.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107408/1/10.1007_s12111-012-9237-y.pdfDescription of 10.1007_s12111-012-9237-y.pdf : Main articl

Factors affecting the initiation of a shared decision making program in obstetric practices

As healthcare systems progress toward initiatives that increase patient engagement, stake-holder hopes are that shared decision making (SDM) will become routine practice. Yet, there is limited empirical evidence to guide such SDM program implementations, particularly in obstetric practices. The first stage of any project implementation is the “initiation stage”, in which project leaders define a project’s purpose and stakeholders and structures are put in place to support the new initiative. Our study’s objective was to identify factors affecting the initiation stage of an SDM program implementation project for TOLAC, trial of labor after Cesarean. We conducted a multiple-case study of an SDM program implementation in three obstetric settings in Washington State. The research design and analysis were guided by implementation science frameworks and project management literature. Data sources included interviews with key informants from the State, SDM tool vendors, and three project sites, as well as implementation documents. The study results provide insight into how the identified project implementation factors provide an essential foundation for informing project planning, execution, and reflection/evaluation. In this study, the State’s decision aid certification program pressured the project sites to shape the project purpose and engage stakeholders that would meet immediate project requirements (specifically, state require-ments). The study reveals that external demands may not be in perfect alignment with the internal necessities required for an SDM program’s long-term viability and sustainability. Findings may be used by implementers and researchers to model and strategize the early stages of SDM program implementation projects, particularly in the obstetric setting