Profil pharmaco-doppler pénien des patients coronariens souffrant de dysfonction érectile à l’Institut de Cardiologie d’Abidjan : une série de 30 cas

Contexte et objectif. La maladie athéromateuse dont la coronaropathie étant une pathologie diffuse peut être prévenue par le contrôle des facteurs de risqué cardiovasculaire. Le but de cette étude était de décrire les caractéristiques pharmaco doppler pénien des patients coronariens souffrant de dysfonction érectile. Méthodes. Il s’agissait d’une série analytique des cas suivie entre juin 2020 et février 2021. Elle concernait des patients ayant des lésions athéromateuses significatives à la coronographie et souffrant de dysfonction érectile. Nous avons évalué les caractéristiques pharmaco doppler pénien. La qualité d’érection était appréciée par le score de rigidité Erectile Hardness Score (EHS). Résultats. Trente-six patients étaient inclus. L’âge moyen était de 56 ± 8,4 ans. le pic de Vitesse systolique au repos (PSVr) moyen des patients était de 13,7 cm/s ± 5,9. Le pic de vitesse systolique post injection (PSV pi) moyen des patients était de 23,9 cm/s ± 5,4. Les causes étaient principalement artérielles de 75%. La qualité d’érection était appréciée selon le score EHS : E1 (83%), E2 (22%), E3 (5%) et E4 (3%). Conclusion. La dysfunction érectile est associée aux facteurs de risque cardiovasculaire selon plusieurs études. L’echodoppler pénien avait occupé une place importante dans le diagnostic étiologique. Les causes retrouvées étaient principalement artérielles avec une baisse de PSVpi<25 cm/s. English title: Penile pharmaco doppler profile of coronary patients with erectile dysfunction at the Abidjan Cardiology Institute: a series of 30 cases Context and objective. Atheromatous disease, including coronary artery disease, is a diffuse condition that can be prevented by controlling cardiovascular risk factors. The aim of this study was to describe the penile pharmaco doppler characteristics of coronary patients with erectile dysfunction. Methods: This was an analytical series study performed from June 2020 to February 2021. It included patients with significant atheromatous lesions on coronography and erectile dysfunction. We assessed penile pharmaco doppler characteristics. Erectile quality was assessed by the Erectile Hardness Score (EHS). Results. Thirty-six patients were involved. Their mean age was 56 ± 8.4 years. The mean peak resting systolic velocity (PSVr) of the patients was 13.7 cm/s ± 5.9. The mean post-injection peak systolic velocity (piPSV) of the patients was 23.9 cm/s ± 5.4. The causes were mainly arterial at 75 %. Erectile quality was assessed according to the EHS score: E1 (83 %), E2 (22 %), E3 (5 %) and E4 (3 %). Conclusion. Erectile dysfunction is associated with cardiovascular risk factors according to several studies. Penile echodoppler had been an important part of the etiological diagnosis. The causes found were mainly arterial with a drop in PSVpi<25 cm/s. Keywords: Coronary artery disease; peak systolic velocity, telediastolic velocity, EHS scor

Clonality of Mycobacterium ulcerans by Using VNTR-MIRU Typing in Ivory Coast (Côte d'Ivoire), West Africa

International audienceBuruli ulcer (BU) is neglected skin disease caused by Mycobacterium ulcerans. The lack of early diagnosis and treatment causes severe disability. In Central and in West Africa, BU is endemic and its control is difficult because the most cases occur in rural regions. The molecular particularity of M. ulcerans was the acquisition of the virulence plasmid pMUM001. Genetic analyses have demonstrated the high diversity with variable number tandem repeats (VNTR) and Mycobacterial Interspersed Repetitive Units (MIRU) in M. ulcerans and in mycolactone producing Mycobacteria (MPMs). Objective: The objective of this study was to investigate the molecular diversity by using MIRU-VNTR method in clinical samples of BU patients in Côte d'Ivoire. Study Design: 21 clinical samples were collected from BU patients in different sites and were first analyzed in molecular diagnosis of BU using two targets insertion sequence IS2404 and keto reductase-B-domain (KR). In a second step, we have analyzed the strains by PCR typing for four specific and sensitive markers MIRU1, VNTR6, ST-1 and VNTR19. Results and Conclusion: 100% of clinical samples were positive in molecular tests for IS2404 and 95% for KR and confirm M. ulcerans in the samples. By PCR typing, we have found 61.9 % positive for MIRU1 and 52%, 85.7%, and 61.9% for VNTR6, ST-1 and VNTR19 respectively. One of sample was negative for all genotyping markers. Two different genetic profiles were identified by MIRU1 and ST-1 loci by gel-analyzed of the amplified products. The VNTR profile C (3,1,1) corresponding of 3 copies MIRU1, 1 copy VNTR6 and 1 copy ST-1 was detected in 28.5% of samples and confirms the West African genotype in Côte d'Ivoire. Different genetic strains of M. ulcerans were co-circulated in the same endemic region in the country. This study has described first the circulating of different genetic strains of M. ulcerans in Côte d'Ivoire