Using bevacizumab in the fight against malignant glioma: First results in Asian patients

Objectives To investigate the efficacy and safety profile of bevacizumab in combination with irinotecan in Hong Kong Chinese patients with recurrent malignant glioma and to determine whether their response differed from that reported in other populations. Design Retrospective study. Setting Two private clinics and a public hospital in Hong Kong. Patients Fourteen individuals who presented with recurrent glioma presenting to the hospital between November 2005 and November 2009. Intervention Salvage therapy with bevacizumab (10 mg/kg) and irinotecan (125 mg/m 2 [340 mg/m 2 for those taking enzyme-inducing antiepileptic drugs]) on a 14-day schedule. Results A radiological response was observed in 12 (86%) of the patients, four (33%) of whom had a complete response. The median progression-free survival was 6 (range, 1-15) months; 71% remained progression-free at 6 months. The median overall survival was 18 (range, 9-61) months. The most common adverse events during the bevacizumab and irinotecan treatment period were haematological; five patients had grade 2/3 adverse events. Pulmonary embolism occurred in two patients, one of whom died. Intracranial haemorrhage was not detected in any of the 14 treated patients. Conclusions Bevacizumab plus irinotecan was at least as effective at treating Chinese patients with recurrent glioma as previously reported in clinical trials in different patient populations.published_or_final_versio

Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases

The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation. We review the considerable and wide-ranging evidence for the involvement of this combination of (su)peroxide and poorly liganded iron in a large number of physiological and indeed pathological processes and inflammatory disorders, especially those involving the progressive degradation of cellular and organismal performance. These diseases share a great many similarities and thus might be considered to have a common cause (i.e. iron-catalysed free radical and especially hydroxyl radical generation). The studies reviewed include those focused on a series of cardiovascular, metabolic and neurological diseases, where iron can be found at the sites of plaques and lesions, as well as studies showing the significance of iron to aging and longevity. The effective chelation of iron by natural or synthetic ligands is thus of major physiological (and potentially therapeutic) importance. As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible. This explains, for instance, the decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference

Concomitant use of Western and Chinese medicine treatments in neurosurgical patients in Hong Kong

Objective: To investigate the profile of concomitant use of Chinese medicine (CM) and Western medical treatment in neurosurgical patients. Methods: A guided questionnaire survey was conducted on 309 Chinese patients under neurosurgical care in a teaching hospital in Hong Kong from June to July 2006. Results: Concomitant use of CM was reported by 25.9% of patients. Age was identified to be associated with the use of CM. Half of the CM-users were unaware of there being potential risks of adverse interactions between neurosurgical and CM treatments. Among the CM-users 85% would continue to receive both treatments but only 52.0% would inform neurosurgeons on their CM use. Patients' perceived lack of benefit from CM was the main reason for not using it although 47.0% indicated their willingness to try CM given better access to information. Conclusions: Informal source was the major channel of CM use amongst patients with neurosurgical conditions. A need for improved patient education and service provision was identified and should become an important consideration for healthcare systems which anticipate an increased use of CM amongst patients. Strategies to enhance doctor-patient communications in mainstream care such as pre-operative checklists for herbal medications and post-operative advice may facilitate the safe and complementary use of both treatment systems. © 2011 Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg.link_to_subscribed_fulltex