Spontaneous formation of flux concentrations in a stratified layer

The negative effective magnetic pressure instability discovered recently in direct numerical simulations (DNS) may play a crucial role in the formation of sunspots and active regions in the Sun and stars. This instability is caused by a negative contribution of turbulence to the effective mean Lorentz force (the sum of turbulent and non-turbulent contributions) and results in formation of large-scale inhomogeneous magnetic structures from initial uniform magnetic field. Earlier investigations of this instability in DNS of stably stratified, externally forced, isothermal hydromagnetic turbulence in the regime of large plasma beta are now extended into the regime of larger scale separation ratios where the number of turbulent eddies in the computational domain is about 30. Strong spontaneous formation of large-scale magnetic structures is seen even without performing any spatial averaging. These structures encompass many turbulent eddies. The characteristic time of the instability is comparable to the turbulent diffusion time, L^2/eta_t, where eta_t is the turbulent diffusivity and L is the scale of the domain. DNS are used to confirm that the effective magnetic pressure does indeed become negative for magnetic field strengths below the equipartition field. The dependence of the effective magnetic pressure on the field strength is characterized by fit parameters that seem to show convergence for larger values of the magnetic Reynolds number.Comment: 14 pages, 8 figures, submitted to special issue "Advances of European Solar Physics" in Solar Physic

Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer

Background: Incidence of early-onset (younger than 50 years of age) colorectal cancer (CRC) is increasing in many countries. Thus, elucidating the role of traditional CRC risk factors in early-onset CRC is a high priority. We sought to determine whether risk factors associated with late-onset CRC were also linked to early-onset CRC and whether association patterns differed by anatomic subsite. Methods: Using data pooled from 13 population-based studies, we studied 3767 CRC cases and 4049 controls aged younger than 50 years and 23 437 CRC cases and 35 311 controls aged 50 years and older. Using multivariable and multinomial logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to assess the association between risk factors and early-onset CRC and by anatomic subsite. Results: Early-onset CRC was associated with not regularly using nonsteroidal anti-inflammatory drugs (OR = 1.43, 95% CI = 1.21 to 1.68), greater red meat intake (OR = 1.10, 95% CI = 1.04 to 1.16), lower educational attainment (OR = 1.10, 95% CI = 1.04 to 1.16), alcohol abstinence (OR = 1.23, 95% CI = 1.08 to 1.39), and heavier alcohol use (OR = 1.25, 95% CI = 1.04 to 1.50). No factors exhibited a greater excess in early-onset compared with late-onset CRC. Evaluating risks by anatomic subsite, we found that lower total fiber intake was linked more strongly to rectal (OR = 1.30, 95% CI = 1.14 to 1.48) than colon cancer (OR = 1.14, 95% CI = 1.02 to 1.27; P =. 04). Conclusion: In this large study, we identified several nongenetic risk factors associated with early-onset CRC, providing a basis for targeted identification of those most at risk, which is imperative in mitigating the rising burden of this disease

Structural equation modeling with heavy tailed distributions

structural model, kurtosis, robust methods, efficiency, power,