Assessment of Altimetry Using Ground-Based GPS Data from the 88S Traverse, Antarctica, in Support of ICESat-2

We conducted a 750 km kinematic GPS survey, referred to as the 88S Traverse, based out of South Pole Station, Antarctica, between December 2017 and January 2018. This ground-based survey was designed to validate space-borne altimetry and airborne altimetry developed at NASA. The 88S Traverse intersects 20% of the ICESat-2 satellite orbits on a route that has been flown by two different Operation IceBridge airborne laser altimeters: the Airborne Topographic Mapper (ATM; 26 October 2014) and the University of Alaska Fairbanks (UAF) Lidar (30 November and 3 December 2017). Here we present an overview of the ground-based GPS data quality and a quantitative assessment of the airborne laser altimetry over a flat section of the ice sheet interior. Results indicate that the GPS data are internally consistent (1:1+- 4:1 cm). Relative to the ground-based 88S Traverse data, the elevation biases for ATM and the UAF lidar range from -9:5 to 3.6 cm, while surface measurement precisions are equal to or better than 14.1 cm. These results suggest that the ground-based GPS data and airborne altimetry data are appropriate for the validation of ICESat-2 surface elevation data

Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers.

Occult bacterial infections represent a worldwide health problem. Differentiating active bacterial infection from sterile inflammation can be difficult using current imaging tools. Present clinically viable methodologies either detect morphologic changes (CT/ MR), recruitment of immune cells (111In-WBC SPECT), or enhanced glycolytic flux seen in inflammatory cells (18F-FDG PET). However, these strategies are often inadequate to detect bacterial infection and are not specific for living bacteria. Recent approaches have taken advantage of key metabolic differences between prokaryotic and eukaryotic organisms, allowing easier distinction between bacteria and their host. In this report, we exploited one key difference, bacterial cell wall biosynthesis, to detect living bacteria using a positron-labeled D-amino acid. After screening several 14C D-amino acids for their incorporation into E. coli in culture, we identified D-methionine as a probe with outstanding radiopharmaceutical potential. Based on an analogous procedure to that used for L-[methyl-11C]methionine ([11C] L-Met), we developed an enhanced asymmetric synthesis of D-[methyl-11C]methionine ([11C] D-Met), and showed that it can rapidly and selectively differentiate both E. coli and S. aureus infections from sterile inflammation in vivo. We believe that the ease of [11C] D-Met radiosynthesis, coupled with its rapid and specific in vivo bacterial accumulation, make it an attractive radiotracer for infection imaging in clinical practice

On quantum coding for ensembles of mixed states

We consider the problem of optimal asymptotically faithful compression for ensembles of mixed quantum states. Although the optimal rate is unknown, we prove upper and lower bounds and describe a series of illustrative examples of compression of mixed states. We also discuss a classical analogue of the problem.Comment: 23 pages, LaTe

Positive impact of pre-stroke surgery on survival following transient focal ischemia in hypertensive rats

We describe a positive influence of pre-stroke surgery on recovery and survival in a commonly used experimental stroke model. Two groups of male, stroke-prone spontaneously hypertensive rats (SHRSPs) underwent transient middle cerebral artery occlusion (tMCAO). Group 1 underwent the procedure without any prior intervention whilst group 2 had an additional general anaesthetic 6 days prior to tMCAO for a cranial burrhole and durotomy. Post-stroke recovery was assessed using a 32 point neurological deficit score and tapered beam walk and infarct volume determined from haematoxylin–eosin stained sections. In group 2 survival was 92% (n = 12) versus 67% in group 1 (n = 18). In addition, post-tMCAO associated weight loss was significantly reduced in group 2. There was no significant difference between the two groups in experimental outcomes: infarct volume (Group 1 317 ± 18.6 mm<sup>3</sup> versus Group 2 332 ± 20.4 mm<sup>3</sup>), and serial (day 0–14 post-tMCAO) neurological deficit scores and tapered-beam walk test. Drilling a cranial burrhole under general anaesthesia prior to tMCAO in SHRSP reduced mortality and gave rise to infarct volumes and neurological deficits similar to those recorded in surviving Group 1 animals. This methodological refinement has significant implications for animal welfare and group sizes required for intervention studies