Application of 3D animation principles and tools in geometrical education

Geometrical education using 3D animation principles and tools represents a new methodology approach and its final result is presented on new way, as multimedia tool. The originality of the paper is based on interdisciplinary approach and use of new technologies. The method derived from the overlap of multiple disciplines such as architecture, structural systems, descriptive geometry, computer animation and programming. Teamwork is comprised of different disciplines since the authors working in different domains of architectural studies. This paper is presented as a visual dynamic educational tool for students of technical and applied arts faculties. The aim is to simplify the perception of geometric forms and the process of their construction. The results leads to the production of geometry with complex topology and could be more developed. So, the results are multilayered, and are the solid basis for further scientific research and further development in practice. The geometrical education target group is the students of the technical and art faculties. It is necessary to emphasize that this work is the beginning of our further scientific research papers in different areas due to an interdisciplinary approach. These areas are: geometrical education, pedagogical theory and psychological aspects of teaching and experimental design in architecture. Aspects and research results presented in this paper are: the basic structure of multimedia learning aid, production methodology, and the final application in education

Application of 3D animation principles and tools in geometrical education

Geometrical education using 3D animation principles and tools represents a new methodology approach and its final result is presented on new way, as multimedia tool. The originality of the paper is based on interdisciplinary approach and use of new technologies. The method derived from the overlap of multiple disciplines such as architecture, structural systems, descriptive geometry, computer animation and programming. Teamwork is comprised of different disciplines since the authors working in different domains of architectural studies. This paper is presented as a visual dynamic educational tool for students of technical and applied arts faculties. The aim is to simplify the perception of geometric forms and the process of their construction. The results leads to the production of geometry with complex topology and could be more developed. So, the results are multilayered, and are the solid basis for further scientific research and further development in practice. The geometrical education target group is the students of the technical and art faculties. It is necessary to emphasize that this work is the beginning of our further scientific research papers in different areas due to an interdisciplinary approach. These areas are: geometrical education, pedagogical theory and psychological aspects of teaching and experimental design in architecture. Aspects and research results presented in this paper are: the basic structure of multimedia learning aid, production methodology, and the final application in education

TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation

Background Poly(ADP-ribosyl)ation (PARylation), a posttranslational modification introduced by PARP-1 and PARP-2, has first been implicated in DNA demethylation due to its role in base excision repair. Recent evidence indicates a direct influence of PARP-dependent PARylation on TET enzymes which catalyse hydroxymethylation of DNA—the first step in DNA demethylation. However, the exact nature of influence that PARylation exerts on TET activity is still ambiguous. In our recent study, we have observed a negative influence of PARP-1 on local TET-mediated DNA demethylation of a single gene and in this study, we further explore PARP–TET interplay. Results Expanding on our previous work, we show that both TET1 and TET2 can be in vitro PARylated by PARP-1 and PARP-2 enzymes and that TET1 PARylation negatively affects the TET1 catalytic activity in vitro. Furthermore, we show that PARylation inhibits TET-mediated DNA demethylation at the global genome level in cellulo. Conclusions According to our findings, PARP inhibition can positively influence TET activity and therefore affect global levels of DNA methylation and hydroxymethylation. This gives a strong rationale for future examination of PARP inhibitors' potential use in the therapy of cancers characterised by loss of 5-hydroxymethylcytosine

Dexamethasone treatment during pregnancy influences the number of TSH cells in rat fetuses

Glucocorticoids and thyroid hormones control many aspects of fetal development. Using immunohistochemistry and stereology, in the present study we investigated the effects of dexamethasone (Dx) administration during pregnancy on pituitary TSH cells of 19-day-old fetuses. Doses of 1.0, 0.5, and 0.5 mg Dx/kg bw/day were given to the dams on three consecutive days starting on day 16 of gestation. Administration of Dx to pregnant rats induced a significant decline of fetal TSH cell number per unit of area and their volume density in comparison with the corresponding controls. Our results showed that maternal Dx administration inhibited multiplication of TSH cells in 19-day-old fetuses.Glukokortikoidi i tiroidni hormoni kontrolišu brojne aspekte razvoja fetusa. Koristeći imunocitohemijui stereološke metode ispitivali smo efekte primene deksametazona (Dks) tokom gestacije na TSH ćelije hipofize fetusa pacova starih 19 dana. Doze od 1.0, 0.5 i 0.5 mg Dks/kg tm/dan primenjivane su gravidnim ženkama tri uzastopna dana, počev od 16. dana gestacije. Tretman Dks kod gravidnih ženki uzrokuje značajno smanjenje broja TSH ćelija fetusa po jedinici površine i njihove volumenske gustine u poređenju sa odgovarajućim kontrolama. Naši rezultati pokazuju da maternalna primena Dks inhibira multiplikaciju TSH ćelija kod fetusa starih 19 dana.Projekat ministarstva br. 143007

The Burnout Syndrome in Medical Academia: Psychometric Properties of the Serbian Version of the Maslach Burnout Inventory—Educators Survey

The aim of this study was to assess the psychometric properties of the Maslach Burnout Inventory—Educators Survey (MBI-ES). The presence of burnout syndrome, its relationship with personality traits, intention to change career and work abroad were assessed in a cross-sectional multi-center trial conducted among educators at three medical faculties in the Western Balkans during 2019. Translation and cultural adaptation were made based on internationally accepted principles. Personality traits were assessed by the Big Five Plus Two questionnaire. In total, 246 medical faculty members, predominantly females (61%), were enrolled. The three-factor structure of the MBI-ES questionnaire (exhaustion, cynicism, and professional efficacy) was validated. Analysis of internal consistency yielded a Cronbach’s alpha of 0.785, indicating scale reliability. The majority of respondents (85.6%) reported moderate level of burnout. Aggressiveness, neuroticism, and negative valence were associated with emotional exhaustion and depersonalization, while extraversion, conscientiousness, openness, and positive valence correlated with personal accomplishment. Emotional exhaustion and depersonalization in a multivariate regression model were significantly associated with intentions to change career and work abroad (p < 0.05). The present study provided evidence for the appropriate metric properties of the Serbian version of MBI-ES. Presence of burnout syndrome, which was identified as a common problem in medical academia, and directly linked to personality traits, affected intention to career change and work abroad