Recurrent pregnancy loss and metabolic syndrome

Objectives: The aim of this study was to evaluate the frequency of metabolic syndrome (MetS) and its components inpatients with unexplained recurrent pregnancy loss (RPL).Material and methods: A cross-sectional study was held including 115 patients with unexplained RPL who were referredto a tertiary center between December 2018 and December 2019. In the study, MetS was classified according to TheNational Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) criteria on the basis of metabolic riskfactors. Frequency of MetS in the patients with unexplained RPL was investigated. The relationship between miscarriagerate and metabolic risk factors was also evaluated.Results: According to our study the percentage of MetS in patients with unexplained RPL was 24.4%. When evaluated accordingto different age groups, it was 18.4% in patients aged 20–29 years, and it was 27.8% in patients aged 30–39 years. Atleast having one of its components were high (82.6%) in all patients with unexplained RPL.Conclusions: The percentage of MetS or of at least having one of its components were high in patients with unexplainedRPL. Increased number of having MetS components were associated with increased miscarriage rate

Follicular steroid hormone levels are associated with fertilization outcome after intracytoplasmic sperm injection

WOS: 000286419000003PubMed ID: 2114450

Serum ischemia modified albumin level and its relationship with the thiol/disulfide balance in placenta percreta patients

The pathogenesis of placenta percreta (PP) is not very well known. This study was designed to analyse the oxidative stress (OS), the thiol/disulphide balance, and ischaemia-modified albumin (IMA) the women with PP. The study included 38 pregnant women with PP and 40 similarly aged healthy pregnant women in their third trimester of gestation. We measured the IMA, native and total thiols, and disulphide concentrations in the maternal sera of all of the participating women. The IMA levels were higher and the native and total thiols were lower in the PP group than in the control group. However, there was no statistical significance with respect to the thiol/disulphide balance between the two groups. The results of this study suggest that an increase in the ischaemia and OS and a decrease in the antioxidant status may contribute to the pathogenesis of PP.Impact statement What is already known on this subject? Placenta percreta (PP) is a serious complication of pregnancy. Although there are several studies investigating the pathophysiological mechanism of PP, whether the pathology results from a lack of decidua or from the over-invasiveness of trophoblasts remains controversial. The pathology of PP is poorly understood. What do the results of this study add? This prospective study has shown an increased ischaemia modified albumin (IMA) and a decreased antioxidant capacity in the patients with placenta percreta. The results from 38 women with PP suggest that the serum concentrations of IMA and the oxidative stress parameters may be able to predict PP in cases of uncertainty. What are the implications of these findings for clinical practice and/or further research? The implication of these findings shed light on understanding the pathogenesis of PP for further research