Modelling cytoskeletal traffic: an interplay between passive diffusion and active transport

We introduce the totally asymmetric exclusion process with Langmuir kinetics (TASEP-LK) on a network as a microscopic model for active motor protein transport on the cytoskeleton, immersed in the diffusive cytoplasm. We discuss how the interplay between active transport along a network and infinite diffusion in a bulk reservoir leads to a heterogeneous matter distribution on various scales. We find three regimes for steady state transport, corresponding to the scale of the network, of individual segments or local to sites. At low exchange rates strong density heterogeneities develop between different segments in the network. In this regime one has to consider the topological complexity of the whole network to describe transport. In contrast, at moderate exchange rates the transport through the network decouples, and the physics is determined by single segments and the local topology. At last, for very high exchange rates the homogeneous Langmuir process dominates the stationary state. We introduce effective rate diagrams for the network to identify these different regimes. Based on this method we develop an intuitive but generic picture of how the stationary state of excluded volume processes on complex networks can be understood in terms of the single-segment phase diagram.Comment: 5 pages, 7 figure

Prediction of invasion from the early stage of an epidemic

Predictability of undesired events is a question of great interest in many scientific disciplines including seismology, economy, and epidemiology. Here, we focus on the predictability of invasion of a broad class of epidemics caused by diseases that lead to permanent immunity of infected hosts after recovery or death. We approach the problem from the perspective of the science of complexity by proposing and testing several strategies for the estimation of important characteristics of epidemics, such as the probability of invasion. Our results suggest that parsimonious approximate methodologies may lead to the most reliable and robust predictions. The proposed methodologies are first applied to analysis of experimentally observed epidemics: invasion of the fungal plant pathogen \emph{Rhizoctonia solani} in replicated host microcosms. We then consider numerical experiments of the SIR (susceptible-infected-removed) model to investigate the performance of the proposed methods in further detail. The suggested framework can be used as a valuable tool for quick assessment of epidemic threat at the stage when epidemics only start developing. Moreover, our work amplifies the significance of the small-scale and finite-time microcosm realizations of epidemics revealing their predictive power.Comment: Main text: 18 pages, 7 figures. Supporting information: 21 pages, 8 figure

Anisotropic renormalized fluctuations in the microwave resistivity in YBCO

We discuss the excess conductivity above Tc due to renormalized order-parameter fluctuations in YBCO at microwave frequencies. We calculate the effects of the uniaxial anisotropy on the renormalized fluctuations in the Hartree approximation, extending the isotropic theory developed by Dorsey [Phys. Rev. B 43, 7575 (1991)]. Measurements of the real part of the microwave resistivity at 24 and 48 GHz and of the dc resistivity are performed on different YBCO films. The onset of the superconducting transition and the deviation from the linear temperature behavior above Tc can be fully accounted for by the extended theory. According to the theoretical calculation here presented, a departure from gaussian toward renormalized fluctuations is observed. Very consistent values of the fundamental parameters (critical temperature, coherence lenghts, penetration depth) of the superconducting state are obtained.Comment: RevTex, 8 pages with 5 figures included, to be published in Physical Review

Model Optimasi Economic Order Quantity Dengan Sistem Parsial Backorder Dan Incremental Discount

Economic Order Quantity model with partial backorder system and incremental discount is an integration of several model of inventory optimation, they were Economic Order Quantity optimation model, Economic Order Quantity optimation model with partial backorder system and Economic Order Quantity optimation model with incremental discount. Beside the discounts are given by supplier, in this model there were two stockout conditions, where the consumers disposed to wait until the order came and consumers did not disposed to wait until the order came

¬Penerapan Model Kooperatif Tipe Numbered Head Together Untuk Meningkatkan Minat Belajar IPA Fisika Siswa Di Kelas Viiib Mts Diniyah Putri Pekanbaru

This study aimed to describe and know that through the implementation of cooperative models Numbered Head Together (NHT) can increase students\u27 interest in science learning in the classroom physics VIIIB MTs Diniyah Putri Pekanbaru on the material pressure. Research subjects in this study were all students in grade VIIIB MTs Diniyah Putri Pekanbaru 2014/2015 school year as many as 23 students. The research design is One Group Pretest-Posttest Design. The technique of collecting data is questionnaires and documentation techniques, data collected in this study are primary data and secondary data. Data were analyzed by using descriptive analysis and inferential analysis. Descriptive analysis was obtained: 1) The interest of student learning in class VIIIB MTs Diniyah Putri Pekanbaru with the implementation of the cooperative model NHT in physics science learning is increased. 2) There is a change of physics students \u27interest in science learning in the material pressure for 11.60% by using the implementation of the cooperative model NHT VIIIB class Diniyah Putri Pekanbaru, and inferential analysis results obtained are significant increase students\u27 interest in science learning physics through the implementation of the cooperative model NHT VIIIB class MTs Diniyah Putri Pekanbaru

Hubungan Aksesibilitas Laporan Keuangan terhadap Akuntabilitas Publik pada Pemerintah Kabupaten Bengkulu Utara

Irta Wijaya, Neri Susanti dan Sulisti Afriani; The purpose of this study is to determine the relationship between the accessibility of financial statements to public accountability to the Local Government of North Bengkulu Regency. Sampling method by purposive sampling. Analysis method using Spearman Rank Correlation analysis. From the research result, it can be concluded that there is a significant correlation between accessibility of financial report and public accountability to North Bengkulu Regency Government which seen from rs count> rs table (0,63> 0,450). While the strength of the relationship between the accessibility of the financial statements with public accountability is strongly apparent from the correlation value of 0.63 is at the interval of 0.60 - 0.799 with strong interpretation

Redistribution of DNA topoisomerase II beta after in vitro stabilization of human erythroleukemic nuclei by heat or Cu++ revealed by confocal microscopy.

Using confocal laser scanning microscope and a monoclonal antibody we have examined by means of indirect immunofluorescence techniques the distribution of DNA topoisomerase II beta (the 180-kDa nucleolar isoform of topoisomerase II) following stabilization of isolated nuclei by exposure to moderate heat (37 degrees or 42 degrees C) or Cu++. In intact cells the antibody specifically decorated the nucleoli. The same pattern was maintained if nuclei were incubated at 0 degree C in a buffer containing spermine/spermidine/KCl or stabilized by means of 0.5 mM Cu++ for 10 minutes at 0 degree C in the same buffer. On the contrary, if stabilization was performed by incubating the nuclei either at 37 degrees or 42 degrees C, the immunoreactivity dispersed all over the nucleus, forming numerous speckles. This phenomenon was not detected if, in addition to spermine/spermidine/KCl, the incubation buffer also contained 5 mM Mg++ and the temperature was 37 degrees C. If the stabilization was performed at 42 degrees C, Mg++ failed to maintain the original distribution of DNA topoisomerase II beta, as seen in intact cells. The analysis on 2-D optical section showed the alteration of the nucleolar profile, particularly at 37 degrees C, even when the samples were treated with Mg++. The 3-D reconstruction figured out the irregularity of the surface at 37 degrees C and the variations of the volume occupied by the fluorescent figures. These were in close proximity to each other both in intact cells and in 0 degree C incubated nuclei; they showed a certain degree of shrinkage in 0 degree C plus Cu++ exposed samples (-20\% of the volume), and, on the contrary, the labeled structures were scattered in a volume increased two- or threefold when exposed to 37 degrees or 42 degrees C, respectively. The addition of Mg++ restored the original spatial relationship and volume at 37 degrees C, but not at 42 degrees C, where the volumetric analysis showed an increase of about 50\%. Our results demonstrate that heat stabilization of isolated nuclei in a buffer without Mg++ (i.e., a technique often employed to prepare the nuclear matrix or scaffold) cannot be considered an optimal procedure to maintain the original distribution of protein within the nucleus

Pengaruh Perendaman Larva dengan Berbagai Dosis Madu Sumbawa terhadap Nisbah Jenis Kelamin dan Pertumbuhan Ikan Nila, Oreochromis Niloticus (Linnaeus, 1758) [Effect Of Immersion Of Larvae At Multiple Doses Sumbawa Honey On Sex Ratio And Growth Of Nile Tilapia, Oreochromis Niloticus (Linnaeus, 1758)

Salah satu USAha pembudidaya dalam meningkatkan produksi adalah dengan cara memelihara populasi tunggal kelamin (monoseks) jantan. Madu merupakan salah satu bahan alami yang mengandung crysin dan penghambat aromatase ber-peran dalam proses pemaskulinan ikan. Penelitian ini bertujuan untuk mengkaji pengaruh perendaman larva ikan nila Oreochromis niloticus (L) dalam media pemeliharaan yang mengandung beberapa dosis madu sumbawa terhadap nisbah kelamin, pertumbuhan, dan laju pertumbuhan. Metode yang digunakan adalah eksperimen Rancangan Acak Leng-kap satu faktor, dengan perlakuan dosis madu sumbawa (0 ml L-1, 10 ml L-1, 20 ml L-1, dan 30 ml L"1). Larva ikan nila direndam pada masing-masing perlakuan selama 12 jam dan tiap perlakuan memiliki tiga ulangan dengan 30 ekor ikan pada tiap perlakuan. Untuk menentukan adanya pengaruh dosis madu sumbawa terhadap keseluruhan parameter pene-litian, dilakukan analisis dengan menggunakan ANOVA (analysis of variance) pada taraf kepercayaan 95%. Hasil pe-nelitian menunjukkan bahwa perbedaan dosis madu yang diberikan dalam proses perendamann tidak berpengaruh nyata terhadap nisbah kelamin ikan dan pertumbuhan ikan nila

Analisis Faktor-faktor Yang Mempengaruhi Kinerja Sistem Informasi Akuntansi Pada Bank Rakyat Indonesia Kantor Cabang Bengkulu

Khaidir, Neri Susanti; The research objective to factors determine the performance of accounting information systems at Bank Rakyat Indonesia Branch Office of Bengkulu. This study is a descriptive study, with a sample are employees of Bank Rakyat Indonesia Branch Office Bengkulu wear or use of accounting information systems as much as 42 employees. Methods of data collection done by survey method, while data analysis using rating scale analysis.The results reveal that the most dominant factor affecting the performance of accounting information systems at Bank Rakyat Indonesia Branch Office Bengkulu end user satisfaction factor is an average of 176, the second factor is the education and training programs by an average of 173, the next factor is the support of top management an average of 168 and the last factor is the ability of a personal technique average of 165