Sphingosine-1-Phosphate Catabolizing Enzymes Predict Better Prognosis in Triple-Negative Breast Cancer Patients and Correlates With Tumor-Infiltrating Immune Cells

Background: Triple-negative breast cancer (TNBC) is associated with a poor prognosis. Sphingosine-1-phosphate (S1P), a potent sphingolipid metabolite, has been implicated in many processes that are important for breast cancer (BC). S1P signaling regulates tumorigenesis, and response to chemotherapy and immunotherapy by affecting the trafficking, differentiation or effector function of tumor-infiltrating immune cells (TIICs).Objective: In this study, using bioinformatics tools and publicly available databases, we have analyzed the prognostic value of S1P metabolizing genes and their correlation with TIICs in BC patients.Methods: The expression of S1P metabolizing genes and receptors was evaluated by the UALCAN cancer database. The correlation between mRNA expression of S1P metabolizing genes and receptors and survival outcome of breast cancer patients was analyzed by the Kaplan-Meier plotter database. The association between the gene expression and infiltration of immune cells in the tumors was analyzed by “Tumor-Infiltrating Immune Estimation Resource (TIMER). In silico protein expression analysis was done using the Human Protein Atlas” database.Results: TNBC patients with lower expression of S1P phosphatase 1 (SGPP1) or lipid phosphate phosphatase 3 (PLPP3) have much shorter relapse-free survival than the patients with a higher expression of these genes. SGPP1 and PLPP3 expression show a strong positive correlation with tumor-infiltrating dendritic cells (DCs), CD4+ and CD8+ T cells, neutrophils, and macrophages in the TNBC subtypes. In addition, S1P receptor 4 (S1PR4), an S1P receptor exhibit a strong positive correlation with DCs, CD4+ and CD8+ T cells and neutrophils in TNBC. We, therefore, conclude that low expression of SGPP1 and PLPP3 may hinder the recruitment of immune cells to the tumor environment, resulting in the blockage of cancer cell clearance and a subsequent poor prognosis

Flavonoid and cancer prevention – Mini review

Flavonoid, symbolize an extraordinary assembly of plant secondary metabolites, in addition new investigations suggest as a traditional medicines, with therapeutic impact. Flavonoid molecules encompass characteristic structures diversity and wide-ranging pharmacological activities that may afford new drug discovery with inventive and prospective therapeutic indications to cancer chemoprevention and chemotherapy. Recent research background enhances predominantly functional activity of Flavonoids for cancer research. In this review we make sure about Flavonoid with all prospective of their anticancerous property

CERTAIN INDIAN MEDICINAL PLANTS SAFEGUARD AGAINST CANCER

ABSTRACT Herbal products are considered to be symbols of protection in comparison to the synthetic products that are regarded as risky to human life and environment. Some Medicinal plants have therapeutic potential due to the occurrence of natural antioxidants functioning as reducing agents, free radical scavengers and quenchers of singlet oxygen. Majority of their natural activity is due to bioactive compounds viz. phenol, polyphenolic, alkaloids, Saponin, and other secondary metabolites. And now the major challenge in pharmaceutical industry is drug improvement and discovery. This review discusses about some Indian medicinal plants with regard to their anti-cancerous property

Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19

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