STAT4: An Initiator of Meta-Inflammation in Adipose Tissue?

Metabolic regulation and immune signaling areclosely linked, as evidenced by both thephysical proximity between metabolic cells(e.g., adipocytes and hepatocytes) and resident macrophages as well as the progression of inflammation in metabolic syndrome. Contrasting the reactions to pathogen infections, meta-inflammation describes a novel type of low-grade, unresolvable immune response that is in the causal pathway to metabolic dysregulation (1). Although howmeta-inflammation is initiated remains unclear, the T-helper cell type 1 (Th1)/Th2 (or M1/M2) paradigm provides a simplified view of how immune cells are involved in readjusting metabolic set points in response to nutrient intake (2). It appears that Th1 cytokines (e.g., interleukin [IL]-12 and interferon-g [IFNg]) or Th1 polarized immune cells pro-mote insulin resistance, whereas Th2 signaling (e.g., IL-4 and IL-13) sustains metabolic homeostasis (3). In mouse genetic models, for example, tipping the Th1/Th2 balanc

How dsDNA breathing enhances its flexibility and instability on short length scales

We study the unexpected high flexibility of short dsDNA which recently has been reported by a number of experiments. Via the Langevin dynamics simulation of our Breathing DNA model, first we observe the formation of bubbles within the duplex and also forks at the ends, with the size distributions independent of the contour length. We find that these local denaturations at a physiological temperature, despite their rare and transient presence, can lower the persistence length drastically for a short DNA segment in agreement with experiment

Effects of the light regime on nutrient assimilation by phytoplankton in the Baja California and northwest Africa upwelling systems

The ability of natural phytoplankton assemblages in the Baja California and northwest Africa upwelling regions to assimilate nitrate, ammonium and silicic acid at simulated in situ light intensity and in the dark, was determined in 6 hr tracer experiments using the stable isotopes 15N and 30Si. Nitrate was almost never taken up in the dark, but dark uptake rates of ammonium and silicic acid ranged from zero to values equal to those measured at saturating light intensity...

On the evolution of mean motion resonances through stochastic forcing: Fast and slow libration modes and the origin of HD128311

Aims. We clarify the response of extrasolar planetary systems in a 2:1 mean motion commensurability with masses ranging from the super Jovian range to the terrestrial range to stochastic forcing that could result from protoplanetary disk turbulence. The behaviour of the different libration modes for a wide range of system parameters and stochastic forcing magnitudes is investigated. The growth of libration amplitudes is parameterized as a function of the relevant physical parameters. The results are applied to provide an explanation of the configuration of the HD128311 system. Methods. We first develop an analytic model from first principles without making the assumption that both eccentricities are small. We also perform numerical N-body simulations with additional stochastic forcing terms to represent the effects of putative disk turbulence. Results. Systems are quickly destabilized by large magnitudes of stochastic forcing but some stability is imparted should systems undergo a net orbital migration. The slow mode, which mostly corresponds to motion of the angle between the apsidal lines of the two planets, is converted to circulation more readily than the fast mode which is associated with oscillations of the semi-major axes. This mode is also vulnerable to the attainment of small eccentricities which causes oscillations between periods of libration and circulation. Conclusions. Stochastic forcing due to disk turbulence may have played a role in shaping the configurations of observed systems in mean motion resonance. It naturally provides a mechanism for accounting for the HD128311 system.Comment: 15 pages, 8 figures, added discussion in h and k coordinates, recommended for publicatio

Vortex pinning by meandering line defects in planar superconductors

To better understand vortex pinning in thin superconducting slabs, we study the interaction of a single fluctuating vortex filament with a curved line defect in (1+1) dimensions. This problem is also relevant to the interaction of scratches with wandering step edges in vicinal surfaces. The equilibrium probability density for a fluctuating line attracted to a particular fixed defect trajectory is derived analytically by mapping the problem to a straight line defect in the presence of a space and time-varying external tilt field. The consequences of both rapid and slow changes in the frozen defect trajectory, as well as finite size effects are discussed. A sudden change in the defect direction leads to a delocalization transition, accompanied by a divergence in the trapping length, near a critical angle.Comment: 9 pages, 9 figure

Knowledge-based vision and simple visual machines

The vast majority of work in machine vision emphasizes the representation of perceived objects and events: it is these internal representations that incorporate the 'knowledge' in knowledge-based vision or form the 'models' in model-based vision. In this paper, we discuss simple machine vision systems developed by artificial evolution rather than traditional engineering design techniques, and note that the task of identifying internal representations within such systems is made difficult by the lack of an operational definition of representation at the causal mechanistic level. Consequently, we question the nature and indeed the existence of representations posited to be used within natural vision systems (i.e. animals). We conclude that representations argued for on a priori grounds by external observers of a particular vision system may well be illusory, and are at best place-holders for yet-to-be-identified causal mechanistic interactions. That is, applying the knowledge-based vision approach in the understanding of evolved systems (machines or animals) may well lead to theories and models that are internally consistent, computationally plausible, and entirely wrong

Nurse Practitioner Autonomy in Georgia: Exploring Barriers to Full Practice Authority

Background: There is a significant shortage of primary care physicians in Georgia, with the greatest needs in rural communities. The evidence suggests that nurse practitioners (NPs) improve the quality of care for patients with chronic diseases and may be the solution to the physician shortage. However, the scope of practice for Georgia NPs is among the most restricted in the United States. Purpose: This policy review project explored the barriers to full practice authority for nurse practitioners in the state of Georgia and assessed the impact of current policy on NPs opening independent practices in rural Georgia. The goal of the project was to build a consensus for legislative change to current NP scope of practice. Methodology: A quantitative design was used to collect data from a large nursing organization in Georgia via convenience sampling. One hundred and seventy-nine NPs responded. However, only 135 participants (N=135) consented. Participants completed an online survey in thirty minutes or less. Some questions required free text responses. One-way ANOVA and correlational analysis were used to determine differences between variables. There were no significant differences between NP characteristics (such as race, age, education level, etc) and the likelihood of opening an independent practice. Results: Most NPs (77%) reported a desire for full scope of practice, 80% believed removal of practice barriers would be an advantage to Georgia NPs, and a significant number said if autonomous practice was granted, they were likely or very likely to open an independent practice in rural Georgia

The Period Variation of and a Spot Model for the Eclipsing Binary AR Bootis

New CCD photometric observations of the eclipsing system AR Boo were obtained from February 2006 to April 2008. The star's photometric properties are derived from detailed studies of the period variability and of all available light curves. We find that over about 56 years the orbital period of the system has varied due to a combination of an upward parabola and a sinusoid rather than in a monotonic fashion. Mass transfer from the less massive primary to the more massive secondary component is likely responsible for at least a significant part of the secular period change. The cyclical variation with a period of 7.57 yrs and a semi-amplitude of 0.0015 d can be produced either by a light-travel-time effect due to an unseen companion with a scaled mass of $M_3 \sin i_3$=0.081 $M_\odot$ or by a magnetic period modulation in the secondary star. Historical light curves of AR Boo, as well as our own, display season-to-season light variability, which are best modeled by including both a cool spot and a hot one on the secondary star. We think that the spots express magnetic dynamo-related activity and offer limited support for preferring the magnetic interpretation of the 7.57-year cycle over the third-body understanding. Our solutions confirm that AR Boo belongs to the W-subtype contact binary class, consisting of a hotter, less massive primary star with a spectral type of G9 and a companion of spectral type K1.Comment: 30 pages, including 6 figures and 9 tables, accepted for publication in A

The Dynamical Origin of the Multi-Planetary System HD45364

The recently discovered planetary system HD45364 which consists of a Jupiter and Saturn mass planet is very likely in a 3:2 mean motion resonance. The standard scenario to form planetary commensurabilities is convergent migration of two planets embedded in a protoplanetary disc. When the planets are initially separated by a period ratio larger than two, convergent migration will most likely lead to a very stable 2:1 resonance for moderate migration rates. To avoid this fate, formation of the planets close enough to prevent this resonance may be proposed. However, such a simultaneous formation of the planets within a small annulus, seems to be very unlikely. Rapid type III migration of the outer planet crossing the 2:1 resonance is one possible way around this problem. In this paper, we investigate this idea in detail. We present an estimate for the required convergent migration rate and confirm this with N-body and hydrodynamical simulations. If the dynamical history of the planetary system had a phase of rapid inward migration that forms a resonant configuration, we predict that the orbital parameters of the two planets are always very similar and hence should show evidence of that. We use the orbital parameters from our simulation to calculate a radial velocity curve and compare it to observations. Our model can explain the observational data as good as the previously reported fit. The eccentricities of both planets are considerably smaller and the libration pattern is different. Within a few years, it will be possible to observe the planet-planet interaction directly and thus distinguish between these different dynamical states.Comment: 9 pages, 9 figures - accepted for publication in Astronomy and Astrophysic

Two-Dimensional Diffusion in the Presence of Topological Disorder

How topological defects affect the dynamics of particles hopping between lattice sites of a distorted, two-dimensional crystal is addressed. Perturbation theory and numerical simulations show that weak, short-ranged topological disorder leads to a finite reduction of the diffusion coefficient. Renormalization group theory and numerical simulations suggest that longer-ranged disorder, such as that from randomly placed dislocations or random disclinations with no net disclinicity, leads to subdiffusion at long times.Comment: 10 pages, 6 figure