Blood Levels of Glutamate and Glutamine in Recent Onset and Chronic Schizophrenia

Converging evidence indicates that dysfunctions in glutamatergic neurotransmission and in the glutamate-glutamine cycle play a role in the pathophysiology of schizophrenia. Here, we investigated glutamate and glutamine levels in the blood of patients with recent onset schizophrenia or chronic schizophrenia compared to healthy controls. Compared with healthy controls, patients with recent onset schizophrenia showed increased glutamine/glutamate ratio, while patients with chronic schizophrenia showed decreased glutamine/glutamate ratio. Results indicate that circulating glutamate and glutamine levels exhibit a dual behavior in schizophrenia, with an increase of glutamine/glutamate ratio at the onset of schizophrenia followed by a decrease with progression of the disorder. Further studies are warranted to elucidate the mechanisms and consequences of changes in circulating glutamate and glutamine in schizophrenia

Psicopatologia da autonomia: a importância do conhecimento psicopatológico nos novos dispositivos de assistência psiquiátrica

O lugar que o conhecimento psicopatológico tem ocupado, e pode vir a ocupar na prática clínica dos centros de atenção psicossocial (CAPS) - serviços comunitários destinados ao tratamento de pacientes com transtornos mentais graves, persistentes, em quadros agudos ou não - é a questão central deste artigo. Analisam-se brevemente as conseqüências da hegemonia da psicopatologia descritiva para o desenho das intervenções nesses serviços e discutese se a psicopatologia do ser social poderia ser ferramenta para o construção de cuidado que visa promover a autonomia possível para os pacientes viverem em comunidade

In Situ Synchrotron X-ray Diffraction and Microstructural Studies on Cold and Hot Stamping Combined with Quenching and Partitioning Processing for Development of Third-Generation Advanced High Strength Steels

A novel combined process of Cold Stamping (CS) and Hot Stamping (HS) with Quenching and Partitioning (Q&P) treatment applied to advanced TRIP-assisted steel has been conducted by thermomechanical simulation to evaluate the influence of CS or HS in the Q&P processing. With this purpose, Q&P, CSQ&P, and HSQ&P cycles were designed to obtain multiphase microstructures containing ferrite, martensite, bainitic-ferrite, and the maximum retained austenite (RA) fraction after the processes. The objective was to investigate the effects of the variables involving the heat treatments, such as the intercritical austenitization temperature, the isothermal and non-isothermal deformation, the amount of deformation, and the temperature and partitioning times, and to analyze their influence on the microstructural and mechanical responses. Time-resolved X-ray diffraction using synchrotron radiation was undertaken in a thermomechanical simulator coupled to the synchrotron light source to understand the influence of time, temperature, and strain on the level of carbon enrichment in austenite. In addition, the in situ austenite transformation kinetics and lattice parameter evolution were tracked, making it possible to optimize the RA fraction at room temperature after Q&P processing. The newly developed combined process is promising as the transformation-induced plasticity phenomenon during deformation can contribute to the formability and energy absorption. The results also indicate that the deformation of austenite promotes the ferrite transformation while suppressing the bainite transformation. It was possible to plot the results in an elongation-mechanical strength diagram, coupled to material property charts, also known as, ‘banana curve’, allowing us to identify and correlate the thermal or thermomechanical treatment conditions that led to an increase in ductility or strength according to the volume fractions of the resulting phases. Comparing the results for the HSQ&P treatments, it was observed that isothermal strains at higher temperatures (≥800 °C) are more advantageous to increase mechanical strength, while non-isothermal strains (starting at 750 °C) are suggested if the objective is the increase in ductility, with mechanical strength being slightly sacrificed.Team Maria Santofimia Navarr