A Qualitative Study of Doctoral Student Supervisory Development

Doctoral students in a Council for Accreditation of Counseling and Related Educational Programs (CACREP) accredited program are required to have training in clinical supervision. Frequently doctoral counseling programs have a supervision practicum course designed to facilitate student development into a supervisor. This qualitative research utilized a collective case study approach to gather descriptions of the experiences doctoral students found most useful about their supervision training. Doctoral students enrolled in a supervision practicum course were asked to describe their experiences as supervisors in training through a semi-structured interview approach. Three broad themes emerged from the data: Facilitation of Development, Formation of Supervisory Style, and Supervisory Roles. Descriptions of the themes and specific experiences doctoral students identified as contributing to their development are explored

Light emitting diode (LED) color and broiler growth: effect of supplementing blue/green LED to white LED light on broiler growth, stress, and welfare

Light emitting diode (LED) lighting provides an affordable lighting option for use in commercial poultry production. However, more information is needed to understand the effects of LED color on broiler welfare and growth. Five consecutive flocks (1 in summer, 1 in fall, 2 in winter, and 1 in spring) of straight run Ross 708 × Ross 708 broilers were reared in commercial type barns for 45 D. For white only (WO) treatment, birds were reared under white LED only (Agrishift MLB). For white supplemented (WS) treatment, birds were reared under white LED (Agrishift MLB) in the center aisle, with supplemental blue/green LED lighting (Agrishift MLBg) above the feed and water lines on either side of the barn. Each barn housed 26,200 chicks, and there were 2 barns in each treatment (n = 52,400/treatment). Treatments were rotated among barns between each flock. On day 45, blood samples were collected from 20 birds/barn (n = 40/treatment) to assess the plasma corticosterone (CORT) level and heterophil/lymphocyte ratio. On day 45, 100 birds/barn (n = 200/treatment) were weighed individually and assigned scores for hock burn and foot pad dermatitis. All measures were affected by trial (P \u3c 0.001). Plasma CORT and body weight were affected by the treatment × trial interaction (P ≤ 0.001). Overall, birds in the WS treatment had higher day 45 live body weight (P \u3c 0.001) and lower hock burn scores (P = 0.032) than birds in the WO treatment. Birds in the WS treatment had higher day 45 body weight overall (P \u3c 0.001) and in trials 1, 3, and 5, although the overall body weight was lower in trials 1, 3, and 5 than in trials 2 and 4. Supplemental blue/green LED improved hock burn scores and increased overall day 45 body weight. However, trial differences suggest that more data are needed to determine whether supplementing blue/green LED to white LED improves body weight gain in mixed sex broiler chickens

Comparison of an intermittent, short-dawn/dusk photoperiod with an increasing, long-dawn/dusk photoperiod on broiler growth, stress, and welfare

Photoperiod has been shown to significantly affect broiler performance. However, the effects of the traditional 1-min dimming period on broiler growth and welfare are unclear. In this study, 4 consecutive trials were conducted to compare the effects of an intermittent, short-dawn/dusk photoperiod (ISD) to an increasing, long-dawn/dusk photoperiod (ILD) on broiler growth, stress, and welfare. Straight run day-of-hatch Ross 708 × Ross 708 broilers were placed in 1 of 4 commercial broiler barns (2 b of 26,200 birds each per treatment) and grown to 45 D of age. The photoperiod in the ISD treatment consisted of 24L:0D day 0 to 6, 16L:8D day 7 to 13, 12L:4D:2L:6D day 14 to 20, 12L:4D:3L:5D day 21 to 27, 12L:4D:4L:4D day 28 to 41, and 13L:3D:5L:3D day 42 to 45, with a 1-min transition between light and dark periods. The photoperiod in the ILD treatment consisted of 23L:1D day 0 to 7, 16L:8D day 8 to 21, 18L:6D day 22 to 32, and 20L:4D day 33 to 45, with a 1-min light/dark transition period day 0 to 7 and a 30-min transition period day 8 to 45. Treatments were rotated among the barns between trials. On day 45, blood samples were collected from 20 birds/barn (n = 40/treatment) to assess plasma corticosterone (CORT) and heterophil/lymphocyte (H/L) ratio. One hundred birds per barn (n = 200/treatment) were weighed individually and assigned scores for hock burn, foot pad dermatitis, and feather condition on day 45. Trial differences were observed for all measures (P ≤ 0.001). Birds in the ISD treatment were heavier on day 45 (P \u3c 0.001) and had lower hock burn (P = 0.044) and foot pad dermatitis (P \u3c 0.001) scores. Birds in the ILD treatment had lower plasma CORT (P \u3c 0.001) and H/L ratio (P \u3c 0.001). No treatment differences were observed for feather condition (P \u3e 0.05). Overall, birds reared under the intermittent, short-dawn/dusk photoperiod had higher day 45 live body weights and lower hock burn and foot pad dermatitis scores, whereas those reared under the increasing, long-dawn/dusk photoperiod had reduced measures of short-term and long-term stress

The effect of HIV infection on time off work in a large cohort of gold miners with known dates of seroconversion

Objectives To estimate the effect of HIV infection on time off work. To provide baseline estimates for economic and actuarial models, and for evaluations of ART and other workplace interventions.Methods A retrospective cohort study of gold miners with known dates of seroconversion to HIV, and an HIV-negative comparison group, used routinely collected data to estimate the proportion of time off work by calendar period (1992-2002, prior to the introduction of ART), age, time since seroconversion and period before death. The authors calculated ORs for overall time off work and RR ratios (RRR, using multinomial logistic regression) for reasons off work relative to being at work.Results 1703 HIV-positive and 4859 HIV-negative men were followed for 34 424 person-years. HIV-positive miners spent a higher proportion of time off work than negative miners (20.7% vs 16.1%) due to greater medical and unauthorised absence. Compared with HIV-negative miners, overall time off work increased in the first 2 years after seroconversion (adjusted OR 1.40 (95% CI 1.36 to 1.45)) and then remained broadly stable for a number years, reaching 38.8% in the final year before death (adjusted OR 3.27, 95% CI 2.95 to 3.63). Absence for medical reasons showed the strongest link to HIV infection, increasing from an adjusted RRR of 2.66 (95% CI 2.45 to 2.90) for the first 2 years since seroconversion to 13.6 (95% CI 11.8 to 15.6) in the year prior to death.Conclusions Time off work provides a quantifiable measure of the effect of HIV on overall morbidity. HIV/AIDS affects both labour supply (increased time off work) and demand for health services (increased medical absence). The effects occur soon after seroconversion and stabilise before reaching very high levels in the period prior to death. Occupational health services are an important setting to identify HIV-infected men early

The impact of confounding on the associations of different adiposity measures with the incidence of cardiovascular disease: a cohort study of 296 535 adults of white European descent

Aims: The data regarding the associations of body mass index (BMI) with cardiovascular (CVD) risk, especially for those at the low categories of BMI, are conflicting. The aim of our study was to examine the associations of body composition (assessed by five different measures) with incident CVD outcomes in healthy individuals. Methods and results: A total of 296 535 participants (57.8% women) of white European descent without CVD at baseline from the UK biobank were included. Exposures were five different measures of adiposity. Fatal and non-fatal CVD events were the primary outcome. Low BMI (≤18.5 kg m−2) was associated with higher incidence of CVD and the lowest CVD risk was exhibited at BMI of 22–23 kg m−2 beyond, which the risk of CVD increased. This J-shaped association attenuated substantially in subgroup analyses, when we excluded participants with comorbidities. In contrast, the associations for the remaining adiposity measures were more linear; 1 SD increase in waist circumference was associated with a hazard ratio of 1.16 [95% confidence interval (CI) 1.13–1.19] for women and 1.10 (95% CI 1.08–1.13) for men with similar magnitude of associations for 1 SD increase in waist-to-hip ratio, waist-to-height ratio, and percentage body fat mass. Conclusion: Increasing adiposity has a detrimental association with CVD health in middle-aged men and women. The association of BMI with CVD appears more susceptible to confounding due to pre-existing comorbidities when compared with other adiposity measures. Any public misconception of a potential ‘protective’ effect of fat on CVD risk should be challenged

Striosome–dendron bouquets highlight a unique striatonigral circuit targeting dopamine-containing neurons

The dopamine systems of the brain powerfully influence movement and motivation. We demonstrate that striatonigral fibers originating in striosomes form highly unusual bouquet-like arborizations that target bundles of ventrally extending dopamine-containing dendrites and clusters of their parent nigral cell bodies. Retrograde tracing showed that these clustered cell bodies in turn project to the striatum as part of the classic nigrostriatal pathway. Thus, these striosome-dendron formations, here termed "striosome-dendron bouquets," likely represent subsystems with the nigro-striato-nigral loop that are affected in human disorders including Parkinson's disease. Within the bouquets, expansion microscopy resolved many individual striosomal fibers tightly intertwined with the dopamine-containing dendrites and also with afferents labeled by glutamatergic, GABAergic, and cholinergic markers and markers for astrocytic cells and fibers and connexin 43 puncta. We suggest that the striosome-dendron bouquets form specialized integrative units within the dopamine-containing nigral system. Given evidence that striosomes receive input from cortical regions related to the control of mood and motivation and that they link functionally to reinforcement and decision-making, the striosome-dendron bouquets could be critical to dopamine-related function in health and disease

Factors associated with failed treatment : an analysis of 121,744 women embarking on their first IVF cycles

Peer reviewedPublisher PD

The Induction of Autoimmune Arthritis and Sex differences in Mice Impact the Lung Inflammatory Response to Repetitive Inhalant Organic Dust Extract Exposures

Asthma, chronic bronchitis and COPD are common adverse respiratory health effects among persons exposed to agriculture organic dust work environments. Occupational inhalant exposures have been increasingly associated with the risk of rheumatoid arthritis (RA) disease development, particularly among males. Agriculture workers have increased risk of RA and generalized bone disease. Chronic lung disease is associated with production of characteristic autoantibodies associated with RA (e.g.anti-citrullinated antibodies), even in absence of RA disease. The mechanistic link between pulmonary inflammation and arthritis (and vice versa) remains poorly understood. Animal models are lacking.https://digitalcommons.unmc.edu/emet_posters/1004/thumbnail.jp

High-Throughput Analysis of Lung Immune Cells in a Combined Murine Model of Agriculture Dust-Triggered Airway Inflammation With Rheumatoid Arthritis

Rheumatoid arthritis (RA)-associated lung disease is a leading cause of mortality in RA, yet the mechanisms linking lung disease and RA remain unknown. Using an established murine model of RA-associated lung disease combining collagen-induced arthritis (CIA) with organic dust extract (ODE)-induced airway inflammation, differences among lung immune cell populations were analyzed by single cell RNA-sequencing. Additionally, four lung myeloid-derived immune cell populations including macrophages, monocytes/macrophages, monocytes, and neutrophils were isolated by fluorescence cell sorting and gene expression was determined by NanoString analysis. Unsupervised clustering revealed 14 discrete clusters among Sham, CIA, ODE, and CIA+ODE treatment groups: 3 neutrophils (inflammatory, resident/transitional, autoreactive/suppressor), 5 macrophages (airspace, differentiating/recruited, recruited, resident/interstitial, and proliferative airspace), 2 T-cells (differentiating and effector), and a single cluster each of inflammatory monocytes, dendritic cells, B-cells and natural killer cells. Inflammatory monocytes, autoreactive/suppressor neutrophils, and recruited/differentiating macrophages were predominant with arthritis induction (CIA and CIA+ODE). By specific lung cell isolation, several interferon-related and autoimmune genes were disproportionately expressed among CIA and CIA+ODE (e.g. Oasl1, Oas2, Ifit3, Gbp2, Ifi44, and Zbp1), corresponding to RA and RA-associated lung disease. Monocytic myeloid-derived suppressor cells were reduced, while complement genes (e.g. C1s1 and Cfb) were uniquely increased in CIA+ODE mice across cell populations. Recruited and inflammatory macrophages/monocytes and neutrophils expressing interferon-, autoimmune-, and complement-related genes might contribute towards pro-fibrotic inflammatory lung responses following airborne biohazard exposures in setting of autoimmune arthritis and could be predictive and/or targeted to reduce disease burden

Shifting patterns of genomic variation in the somatic evolution of papillary thyroid carcinoma

Shows Single Nucleotide Substitutions in the MAPK Pathway. (XLSX 43 kb