Caddo Lake Archaeology: Phase I of Archaeological Investigations Along Harrison Bayou, Harrison County, Texas

An important part of the mission of the Caddo Lake Institute, Inc. and its Caddo Lake Scholars Program is the preservation and protection of the unique and irreplaceable cultural heritage of Caddo Lake and its bioregion, the Big Cypress Bayou watershed. The archaeology team of the Scholars Program is meeting these objectives with the initiation of the Harrison Bayou project by: (a) offering archaeological education and training of teachers, students, and potential mentors, (b) through fieldwork and research, identifying, assessing, and designating archaeological, historical, and cultural resources of the Caddo Lake bioregion, and ( c) formulating and implementing strategies for protecting the bioregion\u27s significant cultural resources

Spectrophotometry of nearby field galaxies: the data

We have obtained integrated and nuclear spectra, as well as U, B, R surface photometry, for a representative sample of 196 nearby galaxies. These galaxies span the entire Hubble sequence in morphological type, as well as a wide range of luminosities (M_B=-14 to -22). Here we present the spectrophotometry for these galaxies. The selection of the sample and the U, B, R surface photometry is described in a companion paper (Paper I). Our goals for the project include measuring the current star formation rates and metallicities of these galaxies, and elucidating their star formation histories, as a function of luminosity and morphology. We thereby extend the work of Kennicutt (1992a) to lower luminosity systems. We anticipate that our study will be useful as a benchmark for studies of galaxies at high redshift. We describe the observing, data reduction and calibration techniques, and demonstrate that our spectrophotometry agrees well with that of Kennicutt. The spectra span the range 3550--7250 A at a resolution (FWHM) of ~6 A, and have an overall relative spectrophotometric accuracy of +/- 6 per cent. We present a spectrophotometric atlas of integrated and nuclear rest-frame spectra, as well as tables of equivalent widths and synthetic colors. We study the correlations of galaxy properties determined from the spectra and images. Our findings include: (1) galaxies of a given morphological class display a wide range of continuum shapes and emission line strengths if a broad range of luminosities are considered, (2) emission line strengths tend to in- crease and continua tend to get bluer as the luminosity decreases, and (3) the scatter on the general correlation between nuclear and integrated H_alpha emission line strengths is large.Comment: Accepted for publication in ApJS (scheduled for Vol.127, 2000 March); 63 pages, LateX, 9 figures and 6 tables included, a spectrophotometric atlas is provided as GIF images, fig 1 as a JPEG image, in a single tar-file; a full 600 dpi version is available at http://www.astro.rug.nl/~nfgs

Five-minute Apgar score and educational outcomes: retrospective cohort study of 751 369 children

Background: The Apgar score is used worldwide for assessing the clinical condition and short-term prognosis of newborn infants. Evidence for a relationship with long-term educational outcomes is conflicting. We investigated whether Apgar score at 5 min after birth was associated with additional support needs (ASN) and educational attainment. Methods: Data on pregnancy, delivery and later educational outcomes for children attending Scottish schools between 2006 and 2011 were collated by linking individual-level data from national educational and maternity databases. The relationship between Apgar score and overall ASN, type-specific ASN and educational attainment was assessed using binary, multinomial and generalised ordinal logistic regression models, respectively. Missing covariate data were imputed. Results: Of the 751 369 children eligible, 9741 (1.3%) had a low or intermediate Apgar score and 49 962 (6.6%) had ASN. Low Apgar score was independently associated with overall ASN status (adjusted OR for Apgar ≤3, OR 1.52 95% CI 1.35 to 1.70), as well as ASN due to cognitive (OR 1.26, 95% CI 1.09 to 1.47), sensory (OR 2.49 95% CI 1.66 to 3.73) and motor (OR 3.57, 95% CI 2.86 to 4.47) impairments. There was a dose-response relationship between Apgar score and overall ASN status: of those scoring 0–3, 10.1% had ASN, compared with 9.1% of those scoring 4–7 and 6.6% of those scoring 7–10. A low Apgar score was associated with lower educational attainment, but this was not robust to adjustment for confounders. Conclusions: Apgar scores are associated with long-term as well as short-term prognoses, and with educational as well as clinical outcomes at the population level

Droplet activation, separation, and compositional analysis: laboratory studies and atmospheric measurements

Droplets produced in a cloud condensation nuclei chamber (CCNC) as a function of supersaturation have been separated from unactivated aerosol particles using counterflow virtual impaction. Residual material after droplets were evaporated was chemically analyzed with an Aerodyne Aerosol Mass Spectrometer (AMS) and the Particle Analysis by Laser Mass Spectrometry (PALMS) instrument. Experiments were initially conducted to verify activation conditions for monodisperse ammonium sulfate particles and to determine the resulting droplet size distribution as a function of supersaturation. Based on the observed droplet size, the counterflow virtual impactor cut-size was set to differentiate droplets from unactivated interstitial particles. Validation experiments were then performed to verify that only droplets with sufficient size passed through the counterflow virtual impactor for subsequent analysis. A two-component external mixture of monodisperse particles was also exposed to a supersaturation which would activate one of the types (hygroscopic salts) but not the other (polystyrene latex spheres or adipic acid). The mass spectrum observed after separation indicated only the former, validating separation of droplets from unactivated particles. Results from ambient measurements using this technique and AMS analysis were inconclusive, showing little chemical differentiation between ambient aerosol and activated droplet residuals, largely due to low signal levels. When employing as single particle mass spectrometer for compositional analysis, however, we observed enhancement of sulfate in droplet residuals

Oncogenic fusion protein BCR-FGFR1 requires the breakpoint cluster region-mediated oligomerization and chaperonin Hsp90 for activation.

Mutation and translocation of fibroblast growth factor receptors often lead to aberrant signaling and cancer. This work focuses on the t(8;22)(p11;q11) chromosomal translocation which creates the breakpoint cluster region (BCR) fibroblast growth factor receptor1 (FGFR1) (BCR-FGFR1) fusion protein. This fusion occurs in stem cell leukemia/lymphoma, which can progress to atypical chronic myeloid leukemia, acute myeloid leukemia, or B-cell lymphoma. This work focuses on the biochemical characterization of BCR-FGFR1 and identification of novel therapeutic targets. The tyrosine kinase activity of FGFR1 is required for biological activity as shown using transformation assays, interleukin-3 independent cell proliferation, and liquid chromatography/mass spectroscopy analyses. Furthermore, BCR contributes a coiled-coil oligomerization domain, also essential for oncogenic transformation by BCR-FGFR1. The importance of salt bridge formation within the coiled-coil domain is demonstrated, as disruption of three salt bridges abrogates cellular transforming ability. Lastly, BCR-FGFR1 acts as a client of the chaperonin heat shock protein 90 (Hsp90), suggesting that BCR-FGFR1 relies on Hsp90 complex to evade proteasomal degradation. Transformed cells expressing BCR-FGFR1 are sensitive to the Hsp90 inhibitor Ganetespib, and also respond to combined treatment with Ganetespib plus the FGFR inhibitor BGJ398. Collectively, these data suggest novel therapeutic approaches for future stem cell leukemia/lymphoma treatment: inhibition of BCR oligomerization by disruption of required salt bridges; and inhibition of the chaperonin Hsp90 complex

Droplet activation, separation, and compositional analysis: laboratory studies and atmospheric measurements [Discussion paper]

Droplets produced in a cloud condensation nucleus chamber as a function of supersaturation have been separated from unactivated aerosol particles using counterflow virtual impaction. Residual material after droplets were evaporated was chemically analyzed with an Aerodyne Aerosol Mass Spectrometer and the Particle Analysis by Laser Mass Spectrometry instrument. Experiments were initially conducted to verify activation conditions for monodisperse ammonium sulfate particles and to determine the resulting droplet size distribution as a function of supersaturation. Based on the observed droplet size, the counterflow virtual impactor cut-size was set to differentiate droplets from unactivated interstitial particles. Validation experiments were then performed to verify that only droplets with sufficient size passed through the counterflow virtual impactor for subsequent analysis. A two-component external mixture of monodisperse particles was also exposed to a supersaturation which would activate one of the types (ammonium sulfate) but not the other (polystyrene latex spheres). The mass spectrum observed after separation indicated only the former, validating separation of droplets from unactivated particles. Results from atmospheric measurements using this technique indicate that aerosol particles often activate predominantly as a function of particle size. Chemical composition is not irrelevant, however, and we observed enhancement of sulfate in droplet residuals using single particle analysis

Is strong CP invariance due to a massless up quark?

A standing mystery in the Standard Model is the unnatural smallness of the strong CP violating phase. A massless up quark has long been proposed as one potential solution. A lattice calculation of the constants of the chiral Lagrangian essential for the determination of the up quark mass, 2 alpha_8 - alpha_5, is presented. We find 2 alpha_8 - alpha_5 = 0.29 +/- 0.18, which corresponds to m_u / m_d = 0.410 +/- 0.036. This is the first such calculation using a physical number of dynamical light quarks, N_f = 3.Comment: 4 pages, 5 figures, submitted to Phys. Rev. Lett., corrected small normalization error in f_pi (conclusions were unaffected), improved lattice spacing analysis, improved finite volume analysi

Revealing the galaxy-halo connection in IllustrisTNG

We use the IllustrisTNG (TNG) simulations to explore the galaxy-halo connection as inferred from state-of-the-art cosmological, magnetohydrodynamical simulations. With the high mass resolution and large volume achieved by combining the 100 Mpc (TNG100) and 300 Mpc (TNG300) volumes, we establish the mean occupancy of central and satellite galaxies and their dependence on the properties of the dark matter haloes hosting them. We derive best-fitting HOD parameters from TNG100 and TNG300 for target galaxy number densities of $\bar{n}_g = 0.032\,h^3$Mpc$^{-3}$ and $\bar{n}_g = 0.016\,h^3$Mpc$^{-3}$, respectively, corresponding to a minimum galaxy stellar mass of $M_\star\sim1.9\times10^9\,{\rm M}_\odot$ and $M_\star\sim3.5\times10^9\,{\rm M}_\odot$, respectively, in hosts more massive than $10^{11}\,{\rm M}_\odot$. Consistent with previous work, we find that haloes located in dense environments, with low concentrations, later formation times, and high angular momenta are richest in their satellite population. At low mass, highly-concentrated haloes and those located in overdense regions are more likely to contain a central galaxy. The degree of environmental dependence is sensitive to the definition adopted for the physical boundary of the host halo. We examine the extent to which correlations between galaxy occupancy and halo properties are independent and demonstrate that HODs predicted by halo mass and present-day concentration capture the qualitative dependence on the remaining halo properties. At fixed halo mass, concentration is a strong predictor of the stellar mass of the central galaxy, which may play a defining role in the fate of the satellite population. The radial distribution of satellite galaxies, which exhibits a universal form across a wide range of host halo mass, is described accurately by the best-fit NFW density profile of their host haloes.Comment: 20 pages, 13 figures, 1 table, comments welcom

The Inferred Cardiogenic Gene Regulatory Network in the Mammalian Heart

Cardiac development is a complex, multiscale process encompassing cell fate adoption, differentiation and morphogenesis. To elucidate pathways underlying this process, a recently developed algorithm to reverse engineer gene regulatory networks was applied to time-course microarray data obtained from the developing mouse heart. Approximately 200 genes of interest were input into the algorithm to generate putative network topologies that are capable of explaining the experimental data via model simulation. To cull specious network interactions, thousands of putative networks are merged and filtered to generate scale-free, hierarchical networks that are statistically significant and biologically relevant. The networks are validated with known gene interactions and used to predict regulatory pathways important for the developing mammalian heart. Area under the precision-recall curve and receiver operator characteristic curve are 9% and 58%, respectively. Of the top 10 ranked predicted interactions, 4 have already been validated. The algorithm is further tested using a network enriched with known interactions and another depleted of them. The inferred networks contained more interactions for the enriched network versus the depleted network. In all test cases, maximum performance of the algorithm was achieved when the purely data-driven method of network inference was combined with a data-independent, functional-based association method. Lastly, the network generated from the list of approximately 200 genes of interest was expanded using gene-profile uniqueness metrics to include approximately 900 additional known mouse genes and to form the most likely cardiogenic gene regulatory network. The resultant network supports known regulatory interactions and contains several novel cardiogenic regulatory interactions. The method outlined herein provides an informative approach to network inference and leads to clear testable hypotheses related to gene regulation

Comprehension of Role Reversal in Chimpanzees: Evidence of Empathy?

Four chimpanzees, Pan troglodytes, were individually trained to cooperate with a human partner on a task that allowed both participants to obtain food rewards. In each chimpanzee-human dyad, one of the participants (the informant) could see which pair of food trays on a four-choice apparatus was baited, but had no means of obtaining it. The other participant (the operator) could pull one of four handles to bring a pair of the trays within reach of both participants, but could not see which choice was correct. Two of the chimpanzees were initially trained as informants and adopted spontaneous gestures to indicate the location of the food. The two other chimpanzees were trained as operators and learned-to respond to the pointing of their human partner. After the chimpanzee subjects reached near perfect performance, the roles in each chimpanzee-human dyad were reversed. Three of the four chimpanzees showed immediate evidence of comprehension of their new social role. The results are discussed in the context of cognitive empathy and the potential for future research on social attribution in non-human primates