562 research outputs found
Induced order and reentrant melting in classical two-dimensional binary clusters
A binary system of classical charged particles interacting through a dipole
repulsive potential and confined in a two-dimensional hardwall trap is studied
by Brownian dynamics simulations. We found that the presence of small particles
\emph{stabilizes} the angular order of the system as a consequence of radial
fluctuations of the small particles. There is an optimum in the increased
rigidity of the cluster as function of the number of small particles. The small
(i.e. defect) particles melt at a lower temperature compared to the big
particles and exhibit a \emph{reentrant} behavior in its radial order that is
induced by the intershell rotation of the big particles.Comment: 7 pages, 3 figure
Structural transitions in vertically and horizontally coupled parabolic channels of Wigner crystals
Structural phase transitions in two vertically or horizontally coupled
channels of strongly interacting particles are investigated. The particles are
free to move in the -direction but are confined by a parabolic potential in
the -direction. They interact with each other through a screened power-law
potential (). In vertically coupled systems the channels
are stacked above each other in the direction perpendicular to the
-plane, while in horizontally coupled systems both channels are aligned
in the confinement direction. Using Monte Carlo (MC) simulations we obtain the
ground state configurations and the structural transitions as a function of the
linear particle density and the separation between the channels. At zero
temperature the vertically coupled system exhibits a rich phase diagram with
continuous and discontinuous transitions. On the other hand the vertically
coupled system exhibits only a very limited number of phase transitions due to
its symmetry. Further we calculated the normal modes for the Wigner crystals in
both cases. From MC simulations we found that in the case of vertically coupled
systems the zigzag transition is only possible for low densities. A
Ginzburg-Landau theory for the zigzag transition is presented, which predicts
correctly the behavior of this transition from which we interpret the
structural phase transition of the Wigner crystal through the reduction of the
Brillouin zone.Comment: 9 pages, 13 figure
Conceptualising humiliation
Humiliation lacks an empirically derived definition, sometimes simply being equated with shame. We approached the conceptualisation of humiliation from a prototype perspective, identifying 61 features of humiliation, some of which are more central to humiliation (e.g. losing self-esteem) than others (e.g. shyness). Prototypical humiliation involved feeling powerless, small, and inferior in a situation in which one was brought down and in which an audience was present, leading the person to appraise the situation as unfair and resulting in a mix of emotions, most notably disappointment, anger, and shame. Some of the features overlapped with those of shame (e.g. looking like a fool, losing self-esteem, presence of an audience) whereas other features overlapped with those of anger (e.g. being brought down, unfairness). Which specific features are present may determine whether the humiliation experience becomes more shame- or anger-like (or a combination thereof)
Response-Time Analysis for Non-Preemptive Periodic Moldable Gang Tasks
Gang scheduling has long been adopted by the high-performance computing community as a way to reduce the synchronization overhead between related threads. It allows for several threads to execute in lock steps without suffering from long busy-wait periods or be penalized by large context-switch overheads. When combined with non-preemptive execution, gang scheduling significantly reduces the execution time of threads that work on the same data by decreasing the number of memory transactions required to load or store the data. In this work, we focus on two main types of gang tasks: rigid and moldable. A moldable gang task has a presumed known minimum and maximum number of cores on which it can be executed at runtime, while a rigid gang task always executes on the same number of cores. This work presents the first response-time analysis for non-preemptive moldable gang tasks. Our analysis is based on the notion of schedule abstraction; a new approach for response-time analysis with the promise of high accuracy. Our experiments on periodic rigid gang tasks show that our analysis is 4.9 times more successful in identifying schedulable tasks than the existing utilization-based test for rigid gang tasks.</p
Belief in karma is associated with perceived (but not actual) trustworthiness
Believers of karma believe in ethical causation where good and bad outcomes can be traced to past moral and immoral acts. Karmic belief may have important interpersonal consequences. We investigated whether American Christians expect more trustworthiness from (and are more likely to trust) interaction partners who believe in karma. We conducted an incentivized study of the trust game where interaction partners had different beliefs in karma and God. Participants expected more trustworthiness from (and were more likely to trust) karma believers. Expectations did not match actual behavior: karmic belief was not associated with actual trustworthiness. These findings suggest that people may use others’ karmic belief as a cue to predict their trustworthiness but would err when doing so
Take it or leave it for something better? Responses to fair offers in ultimatum bargaining
We investigated if responders accept a 50-50 split in a modified version of the ultimatum game, in which rejection yields a higher payoff (€7) than accepting the equal offer (€5). Therefore, the decision to accept the 50-50 split in this modified ultimatum game cannot be perceived as a self-interest act, as opposed to the standard game, in which acceptance may reflect resignation in the knowledge that the equal split is the best one can expect. A substantial proportion of responders accepts the equal split in this modified game (Study 1), which clearly establishes egalitarian preferences. Further studies show that the willingness to accept is not an artifact of indifference towards the extra payoff (Study 2), but reflects true concerns for proposers’ outcomes (Study 3)
Multi-ion conduction bands in a simple model of calcium ion channels
We report self-consistent Brownian dynamics simulations of a simple
electrostatic model of the selectivity filters (SF) of calcium ion channels.
They reveal regular structure in the conductance and selectivity as functions
of the fixed negative charge Qf at the SF. This structure consists of distinct
regions of high conductance (conduction bands) M0, M1, M2 separated by regions
of zero-conductance (stop-bands). Two of these conduction bands, M1 and M2,
demonstrate high calcium selectivity and prominent anomalous mole fraction
effects and can be identified with the L-type and RyR calcium channels.Comment: 14 pages, 9 figures, 38 reference
Time-resolved characterization of the mechanisms of toxicity induced by silica and amino-modified polystyrene on alveolar-like macrophages
Abstract Macrophages play a major role in the removal of foreign materials, including nano-sized materials, such as nanomedicines and other nanoparticles, which they accumulate very efficiently. Because of this, it is recognized that for a safe development of nanotechnologies and nanomedicine, it is essential to investigate potential effects induced by nano-sized materials on macrophages. To this aim, in this work, a recently established model of primary murine alveolar-like macrophages was used to investigate macrophage responses to two well-known nanoparticle models: 50Â nm amino-modified polystyrene, known to induce cell death via lysosomal damage and apoptosis in different cell types, and 50Â nm silica nanoparticles, which are generally considered non-toxic. Then, a time-resolved study was performed to characterize in detail the response of the macrophages following exposure to the two nanoparticles. As expected, exposure to the amino-modified polystyrene led to cell death, but surprisingly no lysosomal swelling or apoptosis were detected. On the contrary, a peculiar mitochondrial membrane hyperpolarization was observed, accompanied by endoplasmic reticulum stress (ER stress), increased cellular reactive oxygen species (ROS) and changes of metabolic activity, ultimately leading to cell death. Strong toxic responses were observed also after exposure to silica, which included mitochondrial ROS production, mitochondrial depolarization and cell death by apoptosis. Overall, these results showed that exposure to the two nanoparticles led to a very different series of intracellular events, suggesting that the macrophages responded differently to the two nanoparticle models. Similar time-resolved studies are required to characterize the response of macrophages to nanoparticles, as a key parameter in nanosafety assessment.</jats:p
Does circumferential patellar denervation result in decreased knee pain and improved patient-reported outcomes in patients undergoing nonresurfaced, simultaneous bilateral TKA?
Background Anterior knee pain, which has a prevalence of 4% to 49% after TKA, may be a cause of patient dissatisfaction after TKA. To limit the occurrence of anterior knee pain, patellar denervation with electrocautery has been proposed. However, studies have disagreed as to the efficacy of this procedure. Questions/purposes We evaluated patients undergoing bilateral, simultaneous TKA procedures without patellar resurfacing to ask: (1) Does circumferential patellar cauterization decrease anterior knee pain (Kujala score) postoperatively compared with non-cauterization of the patella? (2) Does circumferential patellar cauterization result in better functional outcomes based on patient report (VAS score, Oxford knee score, and Knee Injury and Osteoarthritis Outcome Score) than non-cauterization of the patella? (3) Is there any difference in the complication rate (infection, patellar maltracking, fracture, venous thromboembolism, or reoperation rate) between cauterized patellae and non-cauterized patellae? Methods Seventy-eight patients (156 knees) were included in this prospective, quasi-randomized study, with each patient serving as his or her own control. Patellar cauterization was always performed on the right knee during simultaneous, bilateral TKA. Five patients (6%) were lost to follow-up before the 2-year minimum follow-up interval. A single surgeon performed all TKAs using the same type of implant, and osteophyte excision was performed in all patellae, which were left unresurfaced. Patellar cauterization was performed at 2 mm to 3 mm deep and approximately 5 mm circumferentially away from the patellar rim. The preoperative femorotibial angle and degree of osteoarthritis (according to the Kellgren-Lawrence grading system) were measured. Restoration of the patellofemoral joint was assessed using the anterior condylar ratio. Clinical outcomes, consisting of clinician-reported outcomes (ROM and Kujala score) and patient-reported outcomes (VAS pain score, Oxford knee score, and Knee Injury and Osteoarthritis Outcome Score), were evaluated preoperatively and at 1 month and 2 years postoperatively. Preoperatively, the radiologic severity of osteoarthritis, based on the Kellgren-Lawrence classification, was not different between the two groups, nor were the baseline pain and knee scores. The mean femorotibial angle of the two groups was also comparable: 189 degrees +/- 4.9 degrees and 191 degrees +/- 6.3 degrees preoperatively (p = 0.051) and 177 degrees +/- 2.9 degrees and 178 degrees +/- 2.1 degrees postoperatively (p = 0.751) for cauterized and non-cauterized knees, respectively. The preoperative (0.3 +/- 0.06 versus 0.3 +/- 0.07; p = 0.744) and postoperative (0.3 +/- 0.06 versus 0.2 +/- 0.07; p = 0.192) anterior condylar ratios were also not different between the cauterized and non-cauterized groups. Results At the 2-year follow-up interval, no difference was observed in the mean Kujala score (82 +/- 2.9 and 83 +/- 2.6 for cauterized and non-cauterized knees, respectively; mean difference 0.3; 95% confidence interval, -0.599 to 1.202; p = 0.509). The mean VAS pain score was 3 +/- 0.9 in the cauterized knee and 3 +/- 0.7 in the non-cauterized knee (p = 0.920). The mean ROM was 123 degrees +/- 10.8 degrees in the cauterized knee and 123 degrees +/- 10.2 degrees in the non-cauterized knee (p = 0.783). There was no difference between cauterized and non-cauterized patellae in the mean Knee Injury and Osteoarthritis Outcome Score for symptoms (86 +/- 4.5 versus 86 +/- 3.9; p = 0.884), pain (86 +/- 3.8 versus 86 +/- 3.6; p = 0.905), activities (83 +/- 3.2 versus 83 +/- 2.8; p = 0.967), sports (42 +/- 11.3 versus 43 +/- 11.4; p = 0.942), and quality of life (83 +/- 4.9 versus 83 +/- 4.7; p = 0.916), as well as in the Oxford knee score (40 +/- 2.1 versus 41 +/- 1.9; p = 0.771). Complications were uncommon and there were no differences between the groups (one deep venous thromboembolism in the cauterized group and two in the control group; odds ratio 0.49, 95% CI, 0.04-5.56; p = 0.57). Conclusions Patellar cauterization results in no difference in anterior knee pain, functional outcomes, and complication rates compared with non-cauterization of the patella in patients who undergo non-resurfaced, simultaneous, bilateral, primary TKA with a minimum of 2 years of follow-up. We do not recommend circumferential patellar cauterization in non-resurfaced patellae in patients who undergo TKA.Orthopaedics, Trauma Surgery and Rehabilitatio
Environmental Particle Emissions due to Automated Drilling of Polypropylene Composites and Nanocomposites Reinforced with Talc, Montmorillonite and Wollastonite
In this study, the effect on nanoparticle emissions due to drilling on Polypropylene (PP) reinforced with 20% talc, 5% montmorillonite (MMT) and 5% Wollastonite (WO) is investigated. The study is the first to explore the nanoparticle release from WO and talc reinforced composites and compares the results to previously researched MMT. With 5% WO, equivalent tensile properties with a 10 % weight reduction were obtained relative to the reference 20% talc sample. The materials were fabricated through injection moulding. The nanorelease studies were undertaken using the controlled drilling methodology for nanoparticle exposure assessment developed within the European Commission funded SIRENA Life 11 ENV/ES/506 project. Measurements were taken using CPC and DMS50 equipment for real-time characterization and measurements. The particle number concentration (of particles <1000nm) and particle size distribution (4.87nm - 562.34nm) of the particles emitted during drilling were evaluated to investigate the effect of the silicate fillers on the particles released. The nano-filled samples exhibited a 33% decrease (MMT sample) or a 30% increase (WO sample) on the average particle number concentration released in comparison to the neat polypropylene sample. The size distribution data displayed a substantial percentage of the particles released from the PP, PP/WO and PP/MMT samples to be between 5-20nm, whereas the PP/talc sample emitted larger particle diameters.The work is funded by and part of the European Commission Life project named Simulation of the release of nanomaterials from consumer products for environmental exposure assessment (SIRENA, Pr. No. LIFE 11 ENV/ES/596). The access and use of the facilities at the Flemish Institute for Technological Research (VITO) was funded by QualityNano Project through Transnational Access (TA Application VITO-TAF-382 and VITO-TAF-500) under the European Commission, Grant Agreement No: INFRA-2010-262163. Kristof is also thankful for partial funding by the School of Engineering at Robert Gordon University for his studentship
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