Genes involved in the regulation of vascular homeostasis determine renal survival rate in patients with chronic glomerulonephritis

In this study, we analyzed association of genes of vascular homeostasis with hypertension and renal survival of CGN patients. The study sample included 238 patients with CGN and 304 healthy subjects of population control. Ten polymorphisms of ten genes of vascular homeostasis were genotyped through polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP) analysis and TaqMan assays. Association of the genotypes with renal survival was analyzed by the Kaplan-Meier estimato

Association of Interleukins Genes Polymorphic Markers with Speed of CGN’s Advance

The authors investigated associations of polymorphism of interleukins genes with nephritic survivance of the ill with chronic glomerulonephritis among 238 patients with CGN and 241 control group individual

Chemokines Genetic Variants are Associated with Parameters of Humoral Immunity of Patients with Chronic Glomerulonephritis

The authors researched associations of chemokines genes polymorphisms with parameters of humoral immunity of 238 patients with chronic glomerulonephritis and 462 individuals of a control grou

The role of chemokine genes in the formation of terminal stage of chronic renal failure

The data on the role of chemokine genes (+1931A/T CCL4, A/G CXCL11 (rs4512021), -403A/G CCL5, C/G CCL2 (rs2857657), -801G/A CXCL12) in the formation of terminal stage of chronic renal failure, in patients with chronic glomerulonephritis, is presented in the work. It was established, that the allele A CXCL11 (rs4512021) (OR = 1.65) was the marker for the development of terminal stage of chronic renal insufficiency, and the genotype GG CXCL11was a protective factor for the development of terminal stage of chronic renal failure (OR = 0.22

Clinical and genetic research of chronic glomerulonephritis

The paper presents data on interaction of candidate genes (S311C PON2, (-6)A/G AGT, (-1166)A/CAGTR1, (-592)C/A IL-10, VNTR IL-1Ra, T113M IL-9, K198N EDN1, (+46)G/A ADRB2, G/A GNB3 (rs.2301339)) with oligogenic and continuous characters of chronic glomerulonephriti

The effectiveness of glucocorticoid therapy in patients with chronic glomerulonephritis, depending on the polymorphic markers of cytokine genes

The paper presents the results of a study of interrelationships of polymorphic cytokine loci (rs1800629 TNFα, rs909253 Ltα, rs767455 TNFR1 and rs1800469 TGFβ-1) with the features of glucocorticoid therapy in patients with chronic glomerulonephriti

Studying the Impact of the genetic polymorphisms of chemokines on the arterial pressure level and kidney function in patient with the chronic glomerulonephritis

It has been established that the genetic marker А I-TAC (rs 4512021) is the risk factor for genesis of the severe arterial hypertension at the chronic glomerulonephritis (OR=1,65) and the genotypes АА and AG I-TAC are the risk factors of depression of the kidney functio

Genetic factors of decreased kidney function in patients with chronic glomerulonephritis

The article presents the results of studying the interaction of polymorphic variants of vascular homeostasis genes (I/D ACE, 4а/4b eNOS, S311C PON2, (-6) A/G AGT, (-1166) A/С AGTR1, G/A GNB3 (rs.2301339), G460W ADD1, (+46) G/A ADRB2, K198N EDN1, (+6986) G/A CYP3A5) with the state of renal function at the onset of chronic glomerulonephriti

Clinical and genetic study of chronic kidney disease

This paper presents the results of the study of the interrelationships of polymorphic loci of chemokines (rs1719153, rs4512021, rs2107538, rs2857657, rs1801157) with features of humoral immunity in patients with chronic glomerulonephriti

The relationship of molecular-genetic markers of chemokines with clinical manifestations of chronic kidney disease

The article presents the results of studying the relationship of polymorphic variants of chemokine genes (1931A/T CCL4, A/G CXCL11 (rs4512021), - 403A/G CCL5, C/G CCL2 (rs2857657), - 801G/A CXCL12) with the features of clinical manifestations of chronic glomerulonephriti