Rhode Island Community Investment Loan Fund Work Group

This report describes the start-up activities of the Rhode Island Community Investment Loan Fund Work Goup. The appendixes provide a chronology of this process. (Library-derived description)Neirinckx, R. (1986). Rhode Island Community Investment Loan Fund Work Group. Retrieved from http://academicarchive.snhu.eduMaster of Science (M.S.)School of Community Economic Developmen

Effect of Repetition on State Anxiety During a High Platform Lunge Task and Associated Ability to Process Visual and Auditory Cues

Objective: The purpose of this study was to examine the effect of repetition on state anxiety during an anxiety-invoking task and the associated ability to process visual and auditory cues. Methods: Twenty-six females (21.8 2.8 yrs.) were required to perform six lunges, separated by five minutes, from a six-meter platform. Measures of state anxiety were recorded during each attempt including time to jump (Tjump), heart rate (HRjump) and self reported evaluations of somatic (SA) and cognitive anxiety (CA). During the countdown to jump the subjects were exposed to five visual and five auditory pieces of information that they were asked to recall 60 seconds after the lunge. Results: Only 13 of the 26 subjects were able to complete the required six lunges. Those who completed all attempts (Complete Group) had previously reported lower levels of trait anxiety (TA) than the withdraw group and recorded significantly lower Tjump in the first attempt. The Complete Group demonstrated significant reductions in arousal after only one attempt (p Conclusions: The results indicate that the individual response to repetition of an anxiety evoking task is highly variable. When learning skills that induce anxiety, optimal information processing appears to occur in the third or fourth attempt as high levels of anxiety are associated with earlier attempts and complacency can occur with further attempts. Visual cues are processed more readily than auditory cues at all levels of arousal, highlighting the importance of visual instruction strategies. The findings are informative from the perspective of understanding best practice in the learning of anxiety-evoking skills and are therefore relevant in many sporting, educational and vocational settings

Medication-Related Osteonecrosis of the Jaw: New Insights into Molecular Mechanisms and Cellular Therapeutic Approaches

peer reviewedIn recent years, medication-related osteonecrosis of the jaw (MRONJ) became an arising disease due to the important antiresorptive drug prescriptions to treat oncologic and osteoporotic patients, as well as the use of new antiangiogenic drugs such as VEGF antagonist. So far, MRONJ physiopathogenesis still remains unclear. Aiming to better understand MRONJ physiopathology, the first objective of this review would be to highlight major molecular mechanisms that are known to be involved in bone formation and remodeling. Recent development in MRONJ pharmacological treatments showed good results; however, those treatments are not curative and could have major side effects. In parallel to pharmacological treatments, MSC grafts appeared to be beneficial in the treatment of MRONJ, in multiple aspects: (1) recruitment and stimulation of local or regional endogenous cells to differentiate into osteoblasts and thus bone formation, (2) beneficial impact on bone remodeling, and (3) immune-modulatory properties that decrease inflammation. In this context, the second objective of this manuscript would be to summarize the molecular regulatory events controlling osteogenic differentiation, bone remodeling, and osteoimmunology and potential beneficial effects of MSC related to those aspects, in order to apprehend MRONJ and to develop new therapeutic approaches

Adult Bone Marrow: Which Stem Cells for Cellular Therapy Protocols in Neurodegenerative Disorders?

The generation of neuronal cells from stem cells obtained from adult bone marrow is of significant clinical interest in order to design new cell therapy protocols for several neurological disorders. The recent identification in adult bone marrow of stem cells derived from the neural crests (NCSCs) might explain the neuronal phenotypic plasticity shown by bone marrow cells. However, little information is available about the nature of these cells compared to mesenchymal stem cells (MSCs). In this paper, we will review all information available concerning NCSC from adult tissues and their possible use in regenerative medicine. Moreover, as multiple recent studies showed the beneficial effect of bone marrow stromal cells in neurodegenerative diseases, we will discuss which stem cells isolated from adult bone marrow should be more suitable for cell replacement therapy

Autonomous onboard guidance and navigation performance for Earth to Mars transfer missions

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 1992.Includes bibliographical references (p. 113-116).by Peter J. Neirinckx.M.S

Glioma Stem Cells in Pediatric High-Grade Gliomas: From Current Knowledge to Future Perspectives.

In children, high-grade gliomas (HGG) and diffuse midline gliomas (DMG) account for a high proportion of death due to cancer. Glioma stem cells (GSCs) are tumor cells in a specific state defined by a tumor-initiating capacity following serial transplantation, self-renewal, and an ability to recapitulate tumor heterogeneity. Their presence was demonstrated several decades ago in adult glioblastoma (GBM), and more recently in pediatric HGG and DMG. In adults, we and others have previously suggested that GSCs nest into the subventricular zone (SVZ), a neurogenic niche, where, among others, they find shelter from therapy. Both bench and bedside evidence strongly indicate a role for the GSCs and the SVZ in GBM progression, fostering the development of innovative targeting treatments. Such new therapeutic approaches are of particular interest in infants, in whom standard therapies are often limited due to the risk of late effects. The aim of this review is to describe current knowledge about GSCs in pediatric HGG and DMG, i.e., their characterization, the models that apply to their development and maintenance, the specific signaling pathways that may underlie their activity, and their specific interactions with neurogenic niches. Finally, we will discuss the clinical relevance of these observations and the therapeutic advantages of targeting the SVZ and/or the GSCs in infants