Earth observation as a tool for tracking progress towards the Aichi Biodiversity Targets

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An examination of in-season external training load in semi-professional soccer players: considerations of one and two match weekly microcycles

The aim of the present study was to firstly, quantify the external training load (TL) of semi-professional soccer players during an annual season and secondly, to examine the influence of one (1MW) and two (2MW) match weekly microcycles. Data were collected from 24 semi-professional outfield soccer players during the 2018-2019 annual season using micro-electromechanical system (MEMS) devices for the following variables: Training duration (min), total distance (TD), Player Load (PL), high speed running (HSR) distance (5.5-7.0 m/s), and acceleration (ACC) efforts (>2 m/s2). Training sessions were defined as days before match day (i.e. MD minus), with match weeks broken down as either 1MW or 2MW. Data revealed higher TD, PL, and HSR distance on MD and MD-5 when compared to all other MD codes. MD-4 displayed significantly higher values compared to MD-1 (mean differences (Mdiff): TD: 785 ± 158 m; PL: 29 ± 9 au; HSR: 192 ± 63 m; ACC: 15 ± 3 #) and MD-2 (Mdiff: TD: 279 ± 137 m; HSR: 127 ± 54 m). During 2MW scenarios, both TD (Mdiff: 685 ± 328 m) and PL (Mdiff: 33 ± 14 au) were higher on MD-1 when compared to 1MW. However, lower values were observed for duration and HSR on MD-2 and MD-4 during 2MW compared to 1MW scenarios. These data suggest that there appears to be a progressive reduction in TD, PL, HSR and ACC leading into competitive matches based on MD- analysis. However, some variability exists in TL prescription as a result of different MW scenarios (i.e. 1MW vs. 2MW)

Integrative genomic analysis reveals low T-cell infiltration as the primary feature of tobacco use in HPV-positive oropharyngeal cancer

Although tobacco use is an independent adverse prognostic feature in HPV(+) oropharyngeal squamous cell carcinoma (OPSCC), the biologic features associated with tobacco use have not been systematically investigated. We characterized genomic and immunologic features associated with tobacco use through whole exome sequencing, mRNA hybridization, and immunohistochemical staining in 47 HPV(+) OPSCC tumors. Low expression of transcripts in a T cell-inflamed gene expression profile (TGEP) was associated with tobacco use at diagnosis and lower overall and disease-free survival. Tobacco use was associated with an increased proportion of T \u3e C substitutions and a lower proportion of expected mutational signatures, but not with increases in mutational burden or recurrent oncogenic mutations. Our findings suggest that rather than increased mutational burden, tobacco\u27s primary and clinically relevant association in HPV(+) OPSCC is immunosuppression of the tumor immune microenvironment. Quantitative assays of T cell infiltration merit further study as prognostic markers in HPV(+) OPSCC

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis

Monitoring Coastal Water Body Health with Sentinel-2 MSI Imagery

The Australian ‘New South Wales Estuary health assessment and biodiversity monitoring program’ has set state-wide targets for estuary health. A selection of water bodies is being monitored by in situ chlorophyll a concentration and turbidity measurements, indicators for water quality. We investigate whether the current monitoring program can benefit from the use of remote sensing derived data, analyzing chlorophyll a and water clarity estimates by the C2RCC and ACOLITE products based on Sentinel-2 MSI imagery for three lakes along the New South Wales coast. The C2RCC and ACOLITE products were partly successful in predicting chlorophyll a concentration and water clarity. Estimates based on Sentinel-2 MSI imagery were in the range of in situ measurements. However, results varied across years and lakes, and a significant correlation could not be found in every case. It is likely that the physical differences between the systems, such as nutrient input, tannins, and suspended algae/sediment matrix, influence the output of the algorithm. This may preclude the application of a ‘one size fits all’ monitoring approach, given the importance of local ecological phenomena in both influencing remote sensing observations and the nature of appropriate targets. However, the design of a monitoring program that incorporates remote sensing provides a way forward