Diversity of MIS 3 Levallois technology from Motravulapadu, Andhra Pradesh, India‐implications of MIS 3 cultural diversity in South Asia

The chronology and hominin association of the South Asian Middle Palaeolithic have attracted much attention in the last few decades. The emergence of Middle Palaeolithic culture in the region has been debated between the local origins (behavioural change) model based on an early date around 380 ka and the diffusion (biological change) model based on Homo sapiens dispersals from Africa around 120–80 ka. The latter has more consensus, whereas the former requires a more robust chronological framework to attribute the emergence of the Middle Palaeolithic to behavioural changes. In the absence of hominin remains, the presence of Middle Palaeolithic technological trajectories are frequently used as behavioural markers of Homo sapiens. Homo sapiens fossil remains from the regions between Africa and South Asia dated to ∼ 200 ka presents more convincing support for the latter model. Here we present contextual, chronological and technological analysis of Middle Palaeolithic assemblages dated to 52 ka from Motravulapadu, Andhra Pradesh, India. Morphometrical analysis of the lithic assemblage indicates diverse Levallois core reductions were practised at the site at the onset of MIS 3. Further this evidence highlights the significance of MIS 3 cultural diversity in South Asia, likely related to changing population dynamics, cultural drift, and the highly variable climatic context of MIS 3

Height-specific blood pressure cutoffs for screening elevated and high blood pressure in children and adolescents: an International Study.

Pediatric blood pressure (BP) reference tables are generally based on sex, age, and height and tend to be cumbersome to use in routine clinical practice. In this study, we aimed to develop a new, height-specific simple BP table according to the international child BP reference table based on sex, age and height and to evaluate its performance using international data. We validated the simple table in a derivation cohort that included 58,899 children and adolescents aged 6-17 years from surveys in 7 countries (China, India, Iran, Korea, Poland, Tunisia, and the United States) and in a validation cohort that included 70,072 participants from three other surveys (China, Poland and Seychelles). The BP cutoff values for the simple table were calculated for eight height categories for both the 90th ("elevated BP") and 95th ("high BP") percentiles of BP. The simple table had a high performance to predict high BP compared to the reference table, with high values (boys/girls) of area under the curve (0.94/0.91), sensitivity (88.5%/82.9%), specificity (99.3%/99.7%), positive predictive values (93.9%/97.3%), and negative predictive values (98.5%/97.8%) in the pooled data from 10 studies. The simple table performed similarly well for predicting elevated BP. A simple table based on height only predicts elevated BP and high BP in children and adolescents nearly as well as the international table based on sex, age, and height. This has important implications for simplifying the detection of pediatric high BP in clinical practice