The NASA Earth Science Program and Small Satellites

Earth's changing environment impacts every aspect of life on our planet and climate change has profound implications on society. Studying Earth as a single complex system is essential to understanding the causes and consequences of climate change and other global environmental concerns. NASA's Earth Science Division (ESD) shapes an interdisciplinary view of Earth, exploring interactions among the atmosphere, oceans, ice sheets, land surface interior, and life itself. This enables scientists to measure global and climate changes and to inform decisions by Government, other organizations, and people in the United States and around the world. The data collected and results generated are accessible to other agencies and organizations to improve the products and services they provide, including air quality indices, disaster prediction and response, agricultural yield projections, and aviation safety. ESD's Flight Program provides the spacebased observing systems and supporting infrastructure for mission operations and scientific data processing and distribution that support NASA's Earth science research and modeling activities. The Flight Program currently has 21 operating Earth observing space missions, including the recently launched Global Precipitation Measurement (GPM) mission, the Orbiting Carbon Observatory-2 (OCO-2), the Soil Moisture Active Passive (SMAP) mission, and the International Space Station (ISS) RapidSCAT and Cloud-Aerosol Transport System (CATS) instruments. The ESD has 22 more missions and instruments planned for launch over the next decade. These include first and second tier missions from the 2007 Earth Science Decadal Survey, Climate Continuity missions to assure availability of key climate data sets, and small-sized competitively selected orbital missions and instrument missions of opportunity belonging to the Earth Venture (EV) Program. Small satellites (~500 kg or less) are critical contributors to these current and future satellite missions. Some examples are the aforementioned Orbiting Carbon Observatory-2 (OCO-2), the Gravity Recovery and Climate Experiment Follow On (GRACE FO), and the Cyclone Global Navigation Satellite System (CYGNSS) microsatellite constellation. Small satellites also support ESD in space validation and risk reduction of enabling technologies (components and systems). The status of the ESD Flight Program and the role of small satellites will be discussed

Small Satellites for NASA Earth Science

NASAs Earth Science Division (ESD) seeks to develop a scientific understanding of Earth and its response to natural and human-induced changes. Earth is a system comprised of diverse components interacting in complex ways. Understanding Earths atmosphere, surface and interior, oceans and surface water, ice and snow, and life as a single connected system is necessary in order to improve our predictions of climate, weather, and natural hazards. The ESDs Flight Program consists of a coordinated series of satellite and airborne systems providing long and short-term, global and regional observations. In addition, the Flight Program provides infrastructure for operating these missions, processing their scientific data, and distributing them on a free and open basis to researchers, operational users, and the public. The Flight Program currently has 24 operating Earth observing space missions and instruments. There are 18 more missions and instruments planned for launch over the next five years. These comprise missions recommended by the National Academies 2017 Earth Science Decadal Survey, missions and selected instruments to ensure availability of key climate data sets, operational missions to sustain the land imaging provided by the Landsat system, and small-sized competitively selected orbital and instrument missions of opportunity belonging to the Earth Venture (EV) program. The Earth Science Decadal Survey, released in early 2018, recommended four new Flight Program elements in addition to the above activities that comprise the Program of Record (POR). Small satellites (~500 kg or less) are essential components of these activities. Presently, there is an increasing use of micro and nanosatellites (or CubeSats) in constellations to support NASA ESDs scientific objectives. These include the Cyclone Global Navigation Satellite System (CYGNSS) for observing tropical cyclone intensification and genesis factors, the Timed-Resolved Observations of Precipitation structure and storm Intensity with a Constellation of Smallsats (TROPICS) mission, and the Polar Radiant Energy in the Far InfraRed Experiment (PREFIRE) CubeSat mission. ESD small satellite initiatives like the Small Satellite Constellation Data Buy and Venture Class Launch Services (VCLS) are also underway. The Earth Science Technology Offices (ESTO) In-Space Validation of Earth Science Technologies (InVEST) and the Venture Technology program elements have launched seven 3U and 6U CubeSat missions to validate advanced instruments and related technologies. An equivalent number of InVEST and other technology demonstration CubeSats are being prepared for launch in the next year. An overview of plans and current status including topics related to small satellite enabling activities will be presented

The Global Precipitation Measurement (GPM) Mission: Overview and U.S. Status

The Global Precipitation Measurement (GPM) Mission is an international satellite mission specifically designed to unify and advance precipitation measurements from a constellation of research and operational microwave sensors. Building upon the success of the U.S.-Japan Tropical Rainfall Measuring Mission (TRMM), the National Aeronautics and Space Administration (NASA) of the United States and the Japan Aerospace and Exploration Agency (JAXA) will deploy in 2013 a GPM "Core" satellite carrying a KulKa-band Dual-frequency Precipitation Radar (DPR) and a conical-scanning multi-channel (10-183 GHz) GPM Microwave Imager (GMI) to establish a new reference standard for precipitation measurements from space. The combined active/passive sensor measurements will also be used to provide common database for precipitation retrievals from constellation sensors. For global coverage, GPM relies on existing satellite programs and new mission opportunities from a consortium of partners through bilateral agreements with either NASA or JAXA. Each constellation member may have its unique scientific or operational objectives but contributes microwave observations to GPM for the generation and dissemination of unified global precipitation data products. In addition to the DPR and GMI on the Core Observatory, the baseline GPM constellation consists of the following sensors: (1) Special Sensor Microwave Imager/Sounder (SSMIS) instruments on the U.S. Defense Meteorological Satellite Program (DMSP) satellites, (2) the Advanced Microwave Scanning Radiometer- 2 (AMSR-2) on the GCOM-Wl satellite of JAXA, (3) the Multi-Frequency Microwave Scanning Radiometer (MADRAS) and the multi-channel microwave humidity sounder (SAPHIR) on the French-Indian Megha-Tropiques satellite, (4) the Microwave Humidity Sounder (MHS) on the National Oceanic and Atmospheric Administration (NOAA)-19, (5) MHS instruments on MetOp satellites launched by the European Organisation for the Exploitation of Meteorological Satellites (EUMETSAT), (6) the Advanced Technology Microwave Sounder (ATMS) on the National Polar-orbiting Operational Environmental Satellite System (NPOESS) Preparatory Project (NPP), (7) ATMS instruments on the NOAA-NASA Joint Polar Satellite System (JPSS) satellites, and (8) a microwave imager under planning for the Defense Weather Satellite System (DWSS)

The effect of therapeutic glucocorticoids on the adrenal response in a randomized controlled trial in patients with rheumatoid arthritis

Objective. To measure the effect of low-dose systemic glucocorticoid treatment on the adrenal response to adrenocorticotropic hormone (ACTH) in patients with rheumatoid arthritis (RA). Methods. Patients with RA who took part in a randomized double-blind placebo-controlled trial of budesonide (3 mg/day and 9 mg/day) and prednisolone (7.5 mg/day) underwent a short (60-minute) test with injection of ACTH (tetracosactide hexaacetate) at baseline and the day after completing the 3-month treatment program. Plasma cortisol measurements at baseline and 3 months were compared within and between the treatment groups. Individual patients were classified as normal responders to ACTH or as abnormal responders if changes were > 2 SD below the pretreatment value in the entire group of study patients. Results. Short tests with ACTH injection were performed on 139 patients before beginning the study medication and on 134 patients after cessation of the medication. There were no changes in the placebo group. Mean plasma cortisol levels following treatment were reduced in all active treatment groups. In addition, mean values were significantly reduced for the 30-minute and 60-minute responses to ACTH. The maximum reduction (35%) occurred in the prednisolone group at 60 minutes. Following treatment, 34% of patients taking budesonide 9 mg and 46% of those taking prednisolone 7.5 mg failed to reach the normal maximum cortisol response to ACTH. Four patients failed to achieve the normal percentage increase in cortisol levels, but only 1 patient failed to meet both criteria. Conclusion. Low doses of a glucocorticoid resulted in depression of baseline and ACTH-stimulated cortisol levels after 12 weeks of therapy. Although the responsiveness of the hypothalamic-pituitary-adrenal axis in individual patients generally remained within the normal range, these changes should be investigated further

Propuesta esquemática de ordenamiento urbano para la ciudad de Nueva Arica – Lambayeque al año 2022-2032

En la ciudad de Nueva Arica se observa un crecimiento desordenado y la ausencia de equipamiento y baja dotación de servicios; todo esto debido a la improvisación en la construcción por parte de los pobladores y al desinterés de las autoridades por planificar el crecimiento organizado de la ciudad y el mejoramiento en la prestación de servicios, lo que ocasiona que la ciudad se expanda y deprede áreas agrícolas que son zonas con peligro de inundación, y que parte de la población migre para encontrar mejores oportunidades. Por lo cual, se formula esta Propuesta Esquemática de Ordenamiento Urbano, que contribuirá a revertir los problemas de la ciudad, planificando así un ordenado y sostenible mejoramiento de la ciudad, proponiendo pautas necesarias para dar solución a los problemas encontrados y cumplir con los requerimientos necesarios para brindar una adecuada calidad de vida. La propuesta de ordenamiento físico de la ciudad de Nueva Arica parte de la definición de un modelo de desarrollo urbano que expresa apuestas claras de conformación, articulación y funcionamiento, el modelo define la conformación urbana, a partir de su configuración tipo lineal y el desarrollo del área urbana a través del eje comercial y de servicios, circuito vial claramente definidos garantizando el funcionamiento de la ciudad; que permite alcanzar la visión de futuro deseada mediante el cumplimiento de los objetivos estratégicos para el desarrollo de la ciudad

Cubesats for monitoring atmospheric processes (CubeMAP): a constellation mission to study the middle atmosphere

Some aspects of the CubeMAP mission (also known as ESP-MACCS) are presented: its science objectives, and the primary choices made to address them from small satellite platforms. The science case, addressing some key scientific questions related to global change, is elaborated in four objectives focused on upper troposphere and stratospheric composition and its change. The sounding methodology and the associated observation concept retained is a constellation of miniature limb solar occultation thermal infrared sounders, offering the advantages of limb solar occultation, whilst mitigating the inherent lack of coverage of this geometry. The mission focuses on tropical regions as the gateway to the upper troposphere, and the stratosphere. The miniaturized instrument payloads developed for the mission are briefly presented: the High resolution InfraRed Occultation Spectrometer (HIROS) and the Hyperspectral Solar Disk Imager (HSDI). Lastly, the nanosatellite 12U platform and its subsystem are described, completing the overview of the mission space segment

Glucocorticoids—All-Rounders Tackling the Versatile Players of the Immune System

Glucocorticoids regulate fundamental processes of the human body and control cellular functions such as cell metabolism, growth, differentiation, and apoptosis. Moreover, endogenous glucocorticoids link the endocrine and immune system and ensure the correct function of inflammatory events during tissue repair, regeneration, and pathogen elimination via genomic and rapid non-genomic pathways. Due to their strong immunosuppressive, anti-inflammatory and anti-allergic effects on immune cells, tissues and organs, glucocorticoids significantly improve the quality of life of many patients suffering from diseases caused by a dysregulated immune system. Despite the multitude and seriousness of glucocorticoid-related adverse events including diabetes mellitus, osteoporosis and infections, these agents remain indispensable, representing the most powerful, and cost-effective drugs in the treatment of a wide range of rheumatic diseases. These include rheumatoid arthritis, vasculitis, and connective tissue diseases, as well as many other pathological conditions of the immune system. Depending on the therapeutically affected cell type, glucocorticoid actions strongly vary among different diseases. While immune responses always represent complex reactions involving different cells and cellular processes, specific immune cell populations with key responsibilities driving the pathological mechanisms can be identified for certain autoimmune diseases. In this review, we will focus on the mechanisms of action of glucocorticoids on various leukocyte populations, exemplarily portraying different autoimmune diseases as heterogeneous targets of glucocorticoid actions: (i) Abnormalities in the innate immune response play a crucial role in the initiation and perpetuation of giant cell arteritis (GCA). (ii) Specific types of CD4+ T helper (Th) lymphocytes, namely Th1 and Th17 cells, represent important players in the establishment and course of rheumatoid arthritis (RA), whereas (iii) B cells have emerged as central players in systemic lupus erythematosus (SLE). (iv) Allergic reactions are mainly triggered by several different cytokines released by activated Th2 lymphocytes. Using these examples, we aim to illustrate the versatile modulating effects of glucocorticoids on the immune system. In contrast, in the treatment of lymphoproliferative disorders the pro-apoptotic action of glucocorticoids prevails, but their mechanisms differ depending on the type of cancer. Therefore, we will also give a brief insight into the current knowledge of the mode of glucocorticoid action in oncological treatment focusing on leukemia