Practical efficacy and safety of Konsilar D24 in patients with hypertension: data from the KONSONANS program

Aim. In practice, to evaluate the efficacy, safety and long-term adherence to therapy with a fixed-dose combination of ramipril/indapamide (Konsilar-D24) in patients with grade 1-2 hypertension (HTN) who have not achieved blood pressure (BP) control with prior therapy or have not taken antihypertensive therapy.Material and methods. This multicenter open-label observational program included 524 patients with grade 1-2 HTN who did not take antihypertensive therapy or did not reach the target BP level with mono or dual antihypertensive therapy, as well as patients shifted to Konsilar-D24 therapy no later than two weeks before the start of the program. All patients signed a written informed consent to participate in the program. The safety analysis set includes all patients who have taken at least one dose of a fixed-dose combination of ramipril/indapamide and have visited physician at least once during the program. The effectiveness analysis set included all patients in the safety population who completed the study in accordance with protocol (n=511). Clinical systolic blood pressure (SBP), diastolic BP (DBP) and heart rate were assessed at baseline, as well as at 0,5, 1, 3 and 6 months of treatment. A post hoc subgroup analysis of changes in BP and heart rate was performed depending on age, sex and baseline body mass index.Results. The fixed-dose combination of ramipril with indapamide significantly reduced SBP and DBP after 2-week treatment (-20,9±10,1 mm Hg; pConclusion. Despite the limitations inherent in observational studies, the KONSONANS program has demonstrated high efficacy and safety of fixed-dose combination of ramipril/indapamide taken once a day in hypertensive patients. Ramipril/indapamide fixed-dose combination therapy significantly improved BP control and achieved even lower individual target BP levels in the majority of hypertensive patients

Effectiveness, safety, and endothelial function effects of atorvastatin lipid-lowering therapy in coronary heart disease patients undergoing percutaneous coronary intervention

Aim. To study lipid-lowering and pleiotropic atorvastatin effects on lipid metabolism, endothelial function, fibrinogen level in coronary heart disease (CHD) patients who underwent myocardial revascularization (percutaneous coronary intervention). Material and methods. The study included 40 CHD patients who underwent successful coronary angioplasty and stenting. Inclusion criteria were: primary hyperlipidemia with total cholesterol (CH) level >4,5 mmol/l, low-density CH (LDLCH) level >2,5 mmol/l, and triglycerides level ≤3,5 mmol/l. Initial atorvastatin dose was 20 mg/d. Endothelial function was assessed in reactive hyperemia test, with calculation of endothelium-dependent vasodilatation (EDVD) parameter. Carotid artery ultrasound, with intima-media thickness assessment, was performed.The participants were examined at baseline and after 26 therapy weeks. Results. By the end of 14-week therapy period, target LDL-CH level <2,5 mmol/l was achieved in 56% of the patients, and by the end of Week 26 – in 74%. Mean EDVD was 2,8±1,23 at baseline and 2,984±0,881 26 weeks later (р=0,12). Baseline and control negative EDVD percentage was 56,5% and 34,78%, respectively. Therefore, long-term atorvastatin therapy was associated with improved EDVD, decreased negative EDVD percentage, and improved vasoactive endothelial function. Atorvastatin dose of 20 mg/d caused no clinically significantly adverse events during 26-week therapy course. Conclusion. Lipid-lowering therapy with atorvastatin is highly effective and safe. Due to its pleiotropic action, the medication should be used in patients after myocardial revascularization

An open-label multicenter observational study (registry) of patients recovered from coronavirus disease 2019 (COVID-19) with involvement of the cardiovascular system or with baseline severe cardiovascular diseases: rationale, design, and implications for clinical practice

The potential impact on cardiovascular morbidity and mortality have become one of the most important issues of the coronavirus disease 2019 (COVID-19) pandemic. COVID-19 may be associated with more frequent development of acute cardiovascular complications, while patients with established cardiovascular diseases are characterized by a higher risk of severe infection and adverse in-hospital outcomes. Due to the spread scale of the pandemic, understanding the long-term cardiovascular consequences of COVID-19 is of no less importance. Inability to extrapolate available international data to the Russian population has led to the initiation of a national multicenter study (registry) of patients recovered from COVID-19 and with concomitant involvement of the cardiovascular system or with baseline severe cardiovascular diseases. The article presents its rationale, design and implications of the results for clinical practice

Modern antihypertensive therapy: the effectiveness of a unique Russian fixed-dose combination of ramipril and indapamide

Experts consensus of the Russian Cardiology Society (RSC

Arterial hypertension in adults. Clinical guidelines 2020

Arterial hypertension in adults. Clinical guidelines 202