The Ursinus Weekly, March 12, 1951

Curtain Club groups to give plays on April 3 • Edna Millay\u27s poetry read at lit meeting • Ursinus on TV Saturday • Club to visit Seminary • Pageant planned • Forum to feature newspaper writer at March 14 session • Physiotherapist, dental school head to address Pre-med society • Speak Easy hailed as milestone in Ursinus theater work • Fraternities, sororities send out bids as Spring rushing period begins today • MSGA discusses election system • Final tryouts for Spring play to be held Wednesday, Thursday • Livingston gives illustrated talk to large crowd • Dr. Yost at Princeton on busman\u27s holiday • Bloodmobile to re-visit • Chess Club ties • Lantern selects material • Editorial: Story of a letter • Book reviewed • Organ was installed in 1916 as memoriam to C. H. Clark • Smokers warned of moocher\u27s smooth line; Inveterate victim lists defense tactics • IRC-PAC poll gives student views on foreign policy • Mr. Morrison invents zipped turkey; Facilitates the filling of the fowl • Library adds books by American authors • Major Bowen advocates aid to Chiang, says nationalists now ready and able • Dave Reice elected basketball captain • Christensen ends managerial career; Fisher carries on • Garnet downs Delaware to capture league title • Belles gain fifth victory as Vadner scores twenty • Ursinus swimmers beat Beaver mermaids, 34-23 • Fischer and Lintner elected to guide Bruins on grid during \u2751-\u2752 campaign • Baseball squad enters 2nd week of practice • Brodbeck teams lead men\u27s intramural loop • Schedules listed for track, tennis • Seven wrestlers lost by graduation; Basketball squad loses four regulars • Badminton team splits with Drexel, Bryn Mawrhttps://digitalcommons.ursinus.edu/weekly/1562/thumbnail.jp

The Ursinus Weekly, February 18, 1952

1952 Selective Service test set for April • Violinist, pianist schedule program Thursday night • Tryouts held for Meistersingers; Cast is chosen • Egyptian to speak here Wednesday • Communist youth festival described by U.S. delegate • Elections Wednesday as four vie for May Queen • Anne Hughes tells of her college life • Spring play selected by Curtain Club • Drs. Garrett, Miller to address first professors\u27 panel • Mr. Dolman to read Twain at English lit meeting • Sophomores plan eventful weekend for March 7-8 • Summer term students asked to select courses • Tea planned • Editorials: Where there\u27s life; W. Europe forms new army • Whistler Donahue tells of day\u27s activities in Morocco • Operation Lorelei gets underway February 29 • Washington bust given to college by Mr. Lachman • Library is not only for bookworms • Ursinus girls basketball squad overpowers Albright team, 51-23 • Spencer scores 22 as Belles triumph • Off-campus teams lead League II • University of Delaware registers an 81-55 league win over Bears • Girls win in opening meet • Frosh outstanding in winter sports • Grizzlies weak in offense as Dragons win, 82-56 • Grapplers beaten by Delaware team • New accessions to Library include many best-sellers • Teaching is profession, FTA speaker asserts • English Club reads Hamlet • Chess team loses • Couples enjoy Western dance • Chemist addresses Beardwood Society • IRC discusses conferences • MSGA discusses Student Union, parking rules • Students attend NATO conference • WAA card party benefits fundhttps://digitalcommons.ursinus.edu/weekly/1534/thumbnail.jp

ПЕРСПЕКТИВЫ ПОИСКА МУЛЬТИТАРГЕТНЫХ ИНГИБИТОРОВ ТОПОИЗОМЕРАЗ С ПРОТИВООПУХОЛЕВЫМ ДЕЙСТВИЕМ

Purpose of research: to identify the prospects of search for new antitumor non-camptothecin inhibitors of topoisomerase I/II among the various chemical compounds based on the analysis of side effects.Material and Methods. The analysis included 65 relevant literature sources for 2002–2018 years, found in Systems such as Scopus, Web of Science, Pubmed, and eLIBRARY.Results. The antitumor and side effect characteristics of the agents, associated with the selective suppression of the activity of type I and/or II topoisomerase (Top1, Top2) in tumor cells were emphasized. Examples of the relationship between side effects of inhibitors and their structure and catalytic mechanisms were given. The following factors were highlighted as significant: 1) blocking of cells in G2 and S phases with a delay of entry into mitosis; 2) inhibition of the reaction of re-ligation with DNA breaks without re-linking; 3) launching of cytotoxic events with the inhibition of DNA replication and generation of double-strand breaks. Incurable cancers, such as gastric cancer, colorectal cancer, non-small cell lung cancer, hepatocellular carcinoma, glioblastoma, etc. were determined as more sensitive to inhibitors. Side effects of treatment and their connection with the mechanism of activity were described.Conclusion. Based on the comparative analysis of prognostically valuable data regarding the efficacy and safety of topoisomerase I/II inhibitors, multitargeted heterocyclic condensed nitrogen-containing compounds, in particular, anthrafurans, can be considered as new promising clinical candidates with higher selectivity of action.Цель исследования – выявление перспектив поиска новых противоопухолевых некамптотециновых ингибиторов топоизомеразы I/II среди различных химических соединений на основе анализа специфического и побочного действия.Материал и методы. В анализ вошли 65 источников тематической литературы за 2002–2018 гг., найденные в системах Scopus, Web of Science, eLIBRARY и Pubmed.Результаты. Подчеркнуты характеристики противоопухолевого и побочного действия искомых агентов, связанные с избирательным подавлением активности топоизомеразы I и/или II типа (Top1, Top2) в опухолевых клетках. Приведены примеры зависимости специфического и побочного действия ингибиторов от их структуры и каталитических механизмов. Выделены как значимые: 1) блокирование клеток в фазах G2 и S с задержкой вступления в митоз; 2) ингибирование реакции повторного лигирования с разрывами ДНК без повторного связывания; 3) запуск цитотоксических событий с торможением репликации ДНК и генерацией двунитевых разрывов. Определены как более чувствительные к ингибиторам труднокурабельные опухоли (рак желудка, колоректальный рак, немелкоклеточный рак лёгкого, глиобластома, гепатоцеллюлярный рак и пр.). Описаны побочные эффекты лечения и их связь с механизмом активности.Заключение. На основе сравнительного анализа прогностически ценных данных об эффективности и безопасности ингибиторов топоизомеразы I/II в качестве новых перспективных клинических кандидатов с более высокой избирательностью действия можно считать мультитаргетные гетероциклические конденсированные азотсодержащие соединения, в частности антрафураны

BCL2-regulated apoptotic process in myocardial ischemia-reperfusion injury (Review)

The leading cause of death in developed countries is cardiovascular disease, where coronary heart disease is the main cause of death. Myocardial reperfusion is the most significant method to prevent cell death after ischemia. However, restoration of blood flow may paradoxically lead to myocardial ischemia-reperfusion injury (MI/RI) accompanied by metabolic disturbances and cardiomyocyte death. As the myocardium has an extremely limited ability to regenerate, the mechanisms of regulated cell death, including apoptosis, are the most significant for contemporary research due to their reversibility. BCL2 is a key anti-apoptotic protein. There are several signaling pathways and compounds regulating BCL2, including PI3K/AKT and MEK1/ERK1/2, JAK2/STAT3, endothelial nitric oxide synthase, PTEN, cardiac ankyrin repeat protein and microRNA, which can serve as targets for modern methods of cardioprotective therapy inhibiting intrinsic apoptosis and saving viable cardiomyocytes after MI/RI. The present review considers the mechanisms of Bcl2-regulated apoptosis in the development and treatment of MI/RI. © This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License