A randomized, controlled trial comparing ganciclovir to ganciclovir plus foscarnet (each at half dose) for preemptive therapy of cytomegalovirus infection in transplant recipients

Forty-eight patients who provided 2 consecutive blood samples that tested positive for cytomegalovirus DNA by polymerase chain reaction (PCR) were randomized to receive either full-dose ganciclovir ( 5 mg/kg intravenously [iv] twice daily) or half-dose ganciclovir (5 mg/kg iv once daily) plus half-dose foscarnet (90 mg/kg iv once daily) for 14 days. In the ganciclovir arm, 17 (71%) of 24 patients reached the primary end point of being CMV negative by PCR within 14 days of initiation of therapy, compared with 12 (50%) of 24 patients in the ganciclovir-plus-foscarnet arm (P = .12). Toxicity was greater in the combination-therapy arm. In patients who failed to reach the primary end point, baseline virus load was 0.77 log(10) higher, the replication rate before therapy was faster (1.5 vs. 2.7 days), and the viral decay rate was slower (2.9 vs. 1.1 days) after therapy. Bivariable logistic regression models identified baseline virus load, bone-marrow transplantation, and doubling time and half-life of decay as the major factors affecting response to therapy within 14 days. This study did not support a synergistic effect of ganciclovir plus foscarnet in vivo

The role of basic and applied research activities for the improvement of OS&H conditions and the dissemination of the Culture of Safety

Although the European panorama is experiencing a profound change in advance to the Industry 4.0, revolutionizing the world of work with technical, technological and information innovations, in Italy even today we have to deal with the "old" problem of work related injuries and fatalities. In particular, the accident indices of the last few years do not seem to differ much from those typical of the 1970s. The cultural effort matured with the enforcement of the European Directives, with the consequent passage from a rigid prescriptive approach to a flexible one based on risk analysis, is therefore not sufficient to face without “trauma” such rapid technological development accompanied by legislative, productive changes and increasingly widespread reassignment of tasks within the Companies. In this context, the role of scientific research is essential to contribute to technological transfer and scientific knowledge by reconciling the essential aspects of Occupational Safety and Health, through a rigorous and devoted analysis of working scenarios. Furthermore, the dissemination of a Culture of Safety at all levels (Management and Staff roles) can encourage a bilateral synergy "Industry-University" from an OS&H point of view. The present work discusses in more detail the results of the research carried out by the “young” OS&H researchers of the Polytechnic University of Turin presented on the second day of the Conference Dissemination of The Culture of Safety and Health at Work - “Eras of OS&H Development from early ’50 to industry 4.0”

The Relationship Between Bullying Victimization and Perpetration and Non-suicidal Self-injury: A Systematic Review

Experience of bullying may be a significant risk factor for non-suicidal self-injury (NSSI). This study had three aims: to systematically investigate the association between bullying and NSSI, analyze the possible mechanisms underlying the two phenomena, and evaluate any differences between bullying victimization and bullying perpetration with respect to NSSI. A systematic search about the association between bullying victimization and perpetration and NSSI was conducted using specific databases (PubMed, Scopus, Science Direct). The following keywords were used in all database searches: "bullying" AND "NSSI" OR "peer victimization" and NSSI. The searches in PubMed, Scopus and Science Direct revealed a total of 88 articles about bullying or peer victimization and NSSI. However, only 29 met our inclusion criteria and were used for the present review. Overall, all studies examined victimization; four studies also evaluated the effects of perpetration and one included bully-victims. According to the main findings, both being a victim of bullying and perpetrating bullying may increase the risk of adverse psychological outcomes in terms of NSSI and suicidality in the short and the long run. To the best of our knowledge, this is the first review to systematically evaluate the relation between bullying victimization/perpetration and NSSI. The main results support a positive association. Future research should evaluate the possible role of specific mediators/moderators of the association between experience of bullying and NSSI