The indigenous knowledge debate in life sciences: what about Indian indigenous knowledge?

Institute for Science and Technology Education (ISTE

Why do SGLT2 inhibitors reduce heart failure hospitalization? A differential volume regulation hypothesis

The effect of a sodium glucose cotransporter 2 inhibitor (SGLT2i) in reducing heart failure hospitalization in the EMPA-REG OUTCOMES trial has raised the possibility of using these agents to treat established heart failure. We hypothesize that osmotic diuresis induced by SGLT2 inhibition, a distinctly different diuretic mechanism than other diuretic classes, results in greater electrolyte-free water clearance, and ultimately in greater fluid clearance from the interstitial fluid (IF) space than from the circulation, potentially resulting in congestion relief with minimal impact on blood volume, arterial filling, and organ perfusion. We utilize a mathematical model to illustrate that electrolyte-free water clearance results in a greater reduction in IF volume compared to blood volume, and that this difference may be mediated by peripheral sequestration of osmotically inactive sodium. By coupling the model with data on plasma and urinary sodium and water in healthy subjects administered either the SGLT2i dapagliflozin or loop diuretic bumetanide, we predict that dapagliflozin produces a 2-fold greater reduction in IF volume compared to blood volume, while the reduction in IF volume with bumetanide is only 78% of the reduction in blood volume. Heart failure is characterized by excess fluid accumulation, in both the vascular compartment and interstitial space, yet many heart failure patients have arterial underfilling due to low cardiac output, which may be aggravated by conventional diuretic treatment. Thus, we hypothesize that by reducing IF volume to a greater extent than blood volume, SGLT2 inhibitors might provide better control of congestion without reducing arterial filling and perfusion

A new VLA/e-MERLIN limit on central images in the gravitational lens system CLASS B1030+074

We present new VLA 22-GHz and e-MERLIN 5-GHz observations of CLASS B1030+074, a two-image strong gravitational lens system whose background source is a compact flat-spectrum radio quasar. In such systems we expect a third image of the background source to form close to the centre of the lensing galaxy. The existence and brightness of such images is important for investigation of the central mass distributions of lensing galaxies, but only one secure detection has been made so far in a galaxy-scale lens system. The noise levels achieved in our new B1030+074 images reach 3 microJy/beam and represent an improvement in central image constraints of nearly an order of magnitude over previous work, with correspondingly better resulting limits on the shape of the central mass profile of the lensing galaxy. Simple models with an isothermal outer power law slope now require either the influence of a central supermassive black hole, or an inner power law slope very close to isothermal, in order to suppress the central image below our detection limit. Using the central mass profiles inferred from light distributions in Virgo galaxies, moved to z=0.5, and matching to the observed Einstein radius, we now find that 45% of such mass profiles should give observable central images, 10% should give central images with a flux density still below our limit, and the remaining systems have extreme demagnification produced by the central SMBH. Further observations of similar objects will therefore allow proper statistical constraints to be placed on the central properties of elliptical galaxies at high redshift.Comment: Accepted by Monthly Notices of the Royal Astronomical Society. 16 pages, 8 figure

The Spitzer c2d Survey Of Nearby Dense Cores. XI. Infrared And Submillimeter Observations Of CB130

We present new observations of the CB130 region composed of three separate cores. Using the Spitzer Space Telescope, we detected a Class 0 and a Class II object in one of these, CB130-1. The observed photometric data from Spitzer and ground-based telescopes are used to establish the physical parameters of the Class 0 object. Spectral energy distribution fitting with a radiative transfer model shows that the luminosity of the Class 0 object is 0.14-0.16 L-circle dot, which is low for a protostellar object. In order to constrain the chemical characteristics of the core having the low-luminosity object, we compare our molecular line observations to models of lines including abundance variations. We tested both ad hoc step function abundance models and a series of self-consistent chemical evolution models. In the chemical evolution models, we consider a continuous accretion model and an episodic accretion model to explore how variable luminosity affects the chemistry. The step function abundance models can match observed lines reasonably well. The best-fitting chemical evolution model requires episodic accretion and the formation of CO2 ice from CO ice during the low-luminosity periods. This process removes C from the gas phase, providing a much improved fit to the observed gas-phase molecular lines and the CO2 ice absorption feature. Based on the chemical model result, the low luminosity of CB130-1 is explained better as a quiescent stage between episodic accretion bursts rather than being at the first hydrostatic core stage.NASA 1224608, 1288664, 1407, NNX07AJ72G, 1279198, 1288806, 1342425NSF AST-0607793, AST-0708158Korea government (MEST) 2009-0062866Ministry of Education, Science and Technology 2010-0008704Astronom

Addressing patient treatment preferences at trial recruitment.

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