Repeatedly heated mix vegetable oils-induced atherosclerosis and effects of murraya koenigii

Background: Statins are considered as standard drugs to control cholesterol levels, but their use is also associated with renal hypertrophy, hemorrhagic stroke, hepatomegaly, and myopathy. Murraya koenigii is an herb that is used in traditional cuisine and as a medicine in South Asia. Here we assessed the antidyslipidemic and antiatherosclerotic effects of this spice in repeated heated mix vegetable oils (RHMVO)-induced atherosclerotic models.Methods: Aqueous extract of M. koenigii leaves (Mk LE) was prepared and its phytoconstituents were determined. Rabbits were divided into 5 groups (n = 10). Except for the control group, all the other four groups were treated with RHMVO for 16 weeks (dose = 2 ml/kg/day) to induce dyslipidemia and atherosclerosis. These groups were further treated for 10 weeks either with 300 and 500 mg/kg/day Mk LE, lovastatin, RHMVO, or left untreated. Body and organ weights were measured along with oxidative stress and tissue damage parameters. Lipid profile and hepatic function markers were studied. Atheroma measurement and histopathological examination were also performed in control and treated groups.Results: Mk LE significantly (p \u3c 0.05) attenuated RHMVO-induced dyslipidemia and atheroma formation. Furthermore, fat accumulation and lipid peroxidation in hepatic tissues were reduced by Mk LE in a dose-dependent manner. Our results indicated that the antidyslipidemic effects of Mk LE in 500 mg/kg/day dose were comparable to lovastatin. Additionally, oxidative stress markers were reduced much more significantly in Mk LE-500 than in the statin group (p \u3c 0.05).Conclusions: This study recommends Mk LE as a potent antioxidant and lipid-lowering natural medicine that can attenuate the RHMVO-induced atherosclerotic in optimal doses and duration. Therefore, Mk LE can be accessible, cheap, and free of adverse effects alternate to statins

Surah Al Fatiha Induced Betterment of Menstrual Cycle and Hormonal Levels of PCOS: Evidence from Clinical Trials

Introduction Polycystic ovarian syndrome is an endocrinal disorder comprising multiple signs and symptoms that are associated with hormonal imbalance. The intervention was administered to subjects who were reluctant to go for pharmacological intervention. Methodology The designed study was intended to evaluate the effect of Surah Al Fatiha in combating PCOS pathology. Inclusion of females was from teenage to 45 years of age. Rotterdam criteria were used to diagnose 7 PCOS cases, while 7 healthy controls were recruited from the Mamji Hospital in Karachi's gynecology department. Surah Al Fatiha exposure was given to all the subjects. Exposure commenced on second day of subject’s menstrual cycle (three times daily) till the subsequent menstrual cycle started. Surah Al Fatiha, a pre-recorded version by ‘Qari Mishary Rashid Alafasy’ was used in this study. Biochemical parameters were monitored and evaluated before and after the Surah Al Fatiha therapy. Results revealed significantly decreased levels of hormones in PCOS afflicted females after Surah Al Fatiha exposure. Insulin and TSH were restored to their normal levels while rest of the hormones though decreased but were in normal range prior to the exposure of intervention. Conclusion Surah Al Fatiha exposure induces serenity and reduces stress, thus inducing normalization of TSH, decreased IR and in turn regularizing the menstrual cycle